2022 Optogenetic Approaches to Understanding Neural Circuits and Behavior Gordon Research Conference and Gordon Research Seminar

2022年光遗传学方法理解神经回路和行为戈登研究会议和戈登研究研讨会

基本信息

批准号：
10468364
负责人：
Denise Jade Cai
金额：
$ 2.5万
依托单位：
GORDON RESEARCH CONFERENCES
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-05-10 至 2023-05-09
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10468364
关键词：
Address Animals Appointment Behavior Behavioral Biochemical Biosensor Brain Cells Chemicals Communities Complex Cytoskeleton Data Development Discipline Disease Engineering Faculty Feedback Fiber Optics Fostering Fright Funding Gene Delivery Generations Genetic Transcription Goals Growth Head Health Hour Imaging Techniques Learning Light Mentors Mentorship Methods Microscope Microscopy Minority Women Modification Molecular Monitor Motivation Neurobiology Neuromodulator Neurons Neurotransmitters Oral Outcome Participant Phosphotransferases Postdoctoral Fellow Process Research Research Personnel Rewards Scientist Social Behavior Stress Students Symptoms Techniques Technology Time Travel Underrepresented Minority Work addiction base brain behavior brain cell career development cost design experience experimental study graduate student in vivo imaging innovation interest meetings neural circuit neuroregulation next generation novel optogenetics posters programs relating to nervous system sensor support network symposium tool tool development unpublished works

Address Animals Appointment Behavior Behavioral Biochemical Biosensor Brain Cells Chemicals Communities Complex Cytoskeleton Data Development Discipline Disease Engineering Faculty Feedback Fiber Optics Fostering Fright Funding Gene Delivery Generations Genetic Transcription Goals Growth Head Health Hour Imaging Techniques Learning Light Mentors Mentorship Methods Microscope Microscopy Minority Women Modification Molecular Monitor Motivation Neurobiology Neuromodulator Neurons Neurotransmitters Oral Outcome Participant Phosphotransferases Postdoctoral Fellow Process Research Research Personnel Rewards Scientist Social Behavior Stress Students Symptoms Techniques Technology Time Travel Underrepresented Minority Work addiction base brain behavior brain cell career development cost design experience experimental study graduate student in vivo imaging innovation interest meetings neural circuit neuroregulation next generation novel optogenetics posters programs relating to nervous system sensor support network symposium tool tool development unpublished works

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项目摘要

Project Summary A goal of many neurobiologists is to understand how the activity of cells and circuits in the brain relate to behavior, learning, and disease symptoms. Prior to optogenetics, it was nearly impossible to establish the sufficiency and necessity of activity in specific cells to the generation or modification of a behavior. Optogenetics refers to a rapidly progressing set of tools that allow researchers to use light to read out and manipulate the activity of genetically defined brain cells. With optogenetics, it is now possible to use light to monitor the activity of cells during behavior and then add or subtract activity from these cells to establish the causal relationship between it and behavior. Although optogenetics is nearly universally used, the proper design and interpretation of optogenetics-based experiments is still challenging. The goal of the 2022 Gordon Research Conference and Gordon Research Seminar on “Optogenetic Approaches to Understanding Neural Circuits and Behavior” meeting is to gather scientists from different disciplines and backgrounds who can collectively present best methods for use of optogenetic tools and recent discoveries made with optogenetics to a diverse group of scientists interested in uncovering the relationship between circuit activity and behavior. We will bring together experts who are providing new innovations in optogenetic approaches, such as new sensors, effectors, and microscopes, with scientists using these approaches to discover the neural underpinnings of behavior. Our hope is through the multiple opportunities provided (i.e., oral presentations, interactive poster sessions, community meals and free-time) both senior and junior scientists (i.e., trainees and junior faculty) will be able to build connections and learn from each other.We request funds to help offset the cost of travel, accommodation and registration for speakers and participants to attend this meeting.

项目摘要许多神经生物学家的目标是了解大脑中细胞和电路的活性与行为，学习和疾病症状。在使用光遗传学之前，几乎不可能建立特定细胞中的充分性和必要的活动，以产生或修饰行为。光遗传学是指一组快速进步的工具，使研究人员可以使用光来读出和操纵遗传定义的脑细胞的活性。使用光遗传学，现在可以使用光监测行为过程中细胞的活性，然后从这些细胞中添加或减去活动以建立它与行为之间的因果关系。尽管几乎普遍使用了光遗传学，但适当基于光遗传学的实验的设计和解释仍然具有挑战性。 2022年戈登的目标研究会议和戈登研究研讨会“理解神经的光遗传学方法电路和行为”会议是收集来自不同学科和背景的科学家共同提出了使用光遗传学工具和最新发现的最佳方法对于有兴趣发现电路活动与行为之间关系的科学家群体。我们将汇聚在一起，这些专家正在提供光学遗传学方法的新创新，例如新的传感器，效果和显微镜，科学家使用这些方法发现中性行为的基础。我们的希望是通过提供的多种机会（即口头演示，互动海报会议，社区用餐和闲暇时间）高级和初级科学家（即受训者和初级教师）将能够建立联系并互相学习。我们要求资金以抵消演讲者和参与者参加这次会议的旅行费用，住宿和注册费用。