Ion Channels in Context: Structure and function in native cells and macromolecular complexes

上下文中的离子通道：天然细胞和大分子复合物的结构和功能

• 批准号: 10467403
• 负责人: CATHERINE PROENZA
• 金额: $ 3万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467403
• 关键词: Address; Allosteric Regulation; Animals; Atmosphere; Basic Science; Biological; Biophysics; Brain; Cardiovascular Diseases; Career Mobility; Cells; Clinical; Collaborations; Colorado; Communities; Complex; Coupling; Development; Diabetes Mellitus; Disabled Persons; Discipline; Disease; Drug Targeting; Educational workshop; Elements; Environment; Ethnic group; Exposure to; Faculty; Fostering; Friends; Funding; Goals; Heart; Individual; International; Ion Channel; Knowledge; Laboratories; Ligands; Lipids; Logistics; Macromolecular Complexes; Malignant Neoplasms; Maryland; Mentors; Methodology; Molecular; Muscle; Physiological; Physiological Processes; Physiology; Postdoctoral Fellow; Process; Proteins; Race; Regulation; Request for Proposals; Research; Research Personnel; Retina; Role; Schedule; Scientist; Skeletal Muscle; Societies; Structure; Students; System; Time; Translations; Underrepresented Minority; United States National Academy of Sciences; Universities; Woman; Wood material; Work; base; biological systems; body system; career; career development; distinguished professor; diversity and inclusion; fundamental research; innovation; medical schools; meetings; member; nervous system disorder; novel; novel therapeutics; organizational structure; posters; preclinical study; programs; symposium; tool; training opportunity

ABSTRACT This proposal requests funds to support the 75th Annual Symposium of the Society of General Physiologists (SGP), entitled “Ion Channels in Context: Structure and Function in Native Cells and Macromolecular Complexes.” The meeting will be held on September 7-11, 2022 at the Marine Biological Laboratory (MBL) in Woods Hole, MA. The SGP symposium has an established reputation as the leading meeting for physiologists, cell biologists, and biophysicists across all career stages and professional arenas. Each year the meeting topic is unique. In this way, SGP Symposiums highlight timely and emerging topics while leveraging a proven logistical structure, excellent administrative support, and an established base of potential attendees. The 2022 conference will bring together approximately 175 scientists and trainees to discuss novel and fundamental research pertaining to ion channel function in the context of native cells. The size of the meeting, and the venue at the MBL allow presentation of a diverse range of research topics within an environment that maximizes interactions between investigators of different career levels and promotes individual discussions. The overarching goal of the 2022 meeting is to highlight emerging concepts and tools that will promote advances in understanding of how ion channels function in cellular environments. Kurt Beam (National Academy of Sciences, University of Colorado) will deliver the endowed SGP “Friends of Physiology” keynote address. His work on excitation-contraction coupling in skeletal muscle embodies the concept of ion channels working within a macromolecular complex to accomplish a coordinated and fundamental physiological process. The meeting organizers and co-PIs, Drs. Catherine Proenza (University of Colorado) and Matthew Trudeau (University of Maryland) are experts in the field of ion channel function and regulation. They have assembled an enthusiastic group of invited speakers who study a wide range of ion channels in different physiological systems. The invited speakers reflect the commitment of the organizers and the SGP to promoting diversity and equality: 49% are women and 24% are under-represented minorities. Invited speakers also include investigators at all career stages (early 22%, mid 24%, senior 54%). Sessions at the meeting will cover channel function in native cells, channel regulation and allostery, and channel function in disease states. An important goal of the meeting is to foster development and provide opportunities for trainees. To these ends, the schedule includes 3 poster sessions, 24 short talks selected from submitted abstracts, and 2 career development workshops. The specific aims of the symposium are (1) To discuss cutting-edge advances pertaining to ion channel function in physiological contexts; (2) To foster new and interdisciplinary conversations and collaborations; and (3) To Promote early-career investigators and enhance diversity.

抽象的 该建议要求资金支持普通生理学家协会第75届年度研讨会 （SGP），标题为“上下文中的离子通道：本地细胞和大分子中的结构和功能 会议将于2022年9月7日至11日在海洋生物实验室（MBL）举行 马萨诸塞州伍兹霍尔。 SGP研讨会在生理学家领先的会议上既有声誉又有声誉， 细胞生物学家和所有职业阶段和专业领域的生物物理学家。每年会议主题 是独特的。通过这种方式，SGP研讨会突出显示及时和新兴主题，同时利用可靠的后勤 结构，出色的行政支持以及既定的潜在参与者基础。 2022年的会议将汇集大约175名科学家和学员讨论小说和 在天然细胞的背景下，与离子通道功能有关的基本研究。会议的大小， MBL的场地允许在一个环境中介绍潜水员的研究主题 最大化不同职业水平的研究人员之间的互动，并促进个人讨论。这 2022年会议的总体目标是突出新兴的概念和工具，这些概念和工具将促进进步 了解离子通道在细胞环境中的功能。 Kurt Beam（国家科学院， 科罗拉多大学）将提供捐赠的SGP“生理之友”主题演讲。他的工作 骨骼肌中的兴奋量耦合体现了在一个内部工作的离子通道的概念 大分子复合物完成协调和基本的生理过程。会议 组织者和共同理学，博士。凯瑟琳·普罗恩扎（科罗拉多大学）和马修·特鲁多（Matthew Trudeau） 马里兰州）是离子通道功能和调节领域的专家。他们聚集了热情 在不同物理系统中研究各种离子通道的邀请演讲者。受邀 演讲者反映了组织者和SGP促进多样性和平等的承诺：49％是 妇女和24％的少数族裔。受邀演讲者还包括所有职业的调查员 阶段（22％早期，24％，高级54％）。会议上的会议将涵盖天然细胞中的通道功能， 通道调节和变构和疾病状态的通道功能。会议的一个重要目标是 促进发展并为学员提供机会。到这些目的，时间表包括3海报 会议，从提交摘要中选择的24次简短会谈以及2个职业发展研讨会。具体 研讨会的目的是（1）讨论与离子通道功能有关的尖端进步 物理环境； （2）促进新的和跨学科的对话和合作； （3）到 促进早期研究人员并增强多样性。