FASEB SRC: The Consequences of Aneuploidy: Honoring the Contributions of Angelika Amon

FASEB SRC：非整倍体的后果：纪念 Angelika Amon 的贡献

• 批准号: 10467260
• 负责人: Jason Sheltzer
• 金额: $ 3.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-13 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467260
• 关键词: Address; American; Aneuploid Cells; Aneuploidy; Area; Automobile Driving; Biology; Cells; Child; Chromosomal Instability; Chromosome Segregation; Chromosomes; Clinical; Complement; DNA Sequence Alteration; Development; Disease; Down Syndrome; Drug resistance; Event; Exhibits; Extinction (Psychology); Friends; Funding; Genes; Genetic; Goals; Grant; Growth; Haploidy; Health; Human; Husband; Individual; Intellectual functioning disability; International; Logistics; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of ovary; Massachusetts; Memory; Organism; Patient-Focused Outcomes; Physiology; Research; Research Personnel; Science; Scientist; Secure; Series; Societies; Stress; United States; Widowhood; base; career; career development; chromosome missegregation; cost; dosage; experience; member; outreach; posters; professor; symposium; tumor; Address; American; Aneuploid Cells; Aneuploidy; Area; Automobile Driving; Biology; Cells; Child; Chromosomal Instability; Chromosome Segregation; Chromosomes; Clinical; Complement; DNA Sequence Alteration; Development; Disease; Down Syndrome; Drug resistance; Event; Exhibits; Extinction (Psychology); Friends; Funding; Genes; Genetic; Goals; Grant; Growth; Haploidy; Health; Human; Husband; Individual; Intellectual functioning disability; International; Logistics; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of ovary; Massachusetts; Memory; Organism; Patient-Focused Outcomes; Physiology; Research; Research Personnel; Science; Scientist; Secure; Series; Societies; Stress; United States; Widowhood; base; career; career development; chromosome missegregation; cost; dosage; experience; member; outreach; posters; professor; symposium; tumor

Abstract We are requesting grant support for a new FASEB conference entitled “The Consequences of Aneuploidy: Honoring the Contributions of Angelika Amon.” This conference will be held from September 11th to 16th, 2022, in Southbridge, Massachusetts. The broad goals for this conference are two-fold: first, to bring together the world’s leading experts in studying the consequences of aneuploidy, and second, to honor the contributions of Angelika Amon, a pioneer of aneuploidy research who passed away from ovarian cancer in 2020. Aneuploidy, or a chromosome copy number state that is not a whole-number multiple of an organism’s normal haploid complement, is a hallmark of malignant growth and is the most common genetic cause of intellectual disability. Current sequencing-based estimates suggest that up to 90% of human tumors exhibit aneuploidy, and high levels of aneuploidy are associated with metastatic disease, drug resistance, and dismal patient outcomes. Despite the ubiquity of aneuploidy in cancer and its significance to human health, there are no regular conferences in the United States dedicated to sharing the latest advances on this class of genomic alterations. We aim to establish a new conference on this topic that will serve as a forum to bring together scientists to share the latest advances in this exciting and fast-moving field. The organizing team for this conference consists of leading aneuploidy researchers who were Angelika’s colleagues and trainees and are convening this inaugural conference in her memory. This team has already secured the support of FASEB for this conference, which will provide significant organizational, logistic, and technical support for the event. R13 grant funding is being requested to subsidize the costs for early-career researchers and researchers from under-represented backgrounds to attend this event. We currently have 41 confirmed speakers across 10 topic areas related to aneuploidy and chromosome segregation, with a particular focus on the impact of aneuploidy on tumor development and human health. Additional programming is planned for early-career scientists, including a series of short talks, two poster sessions, and several career-development events.

抽象的 我们要求对新的FaseB会议的赠款支持，标题为“ Aneuploidy的后果： 这次会议将于2022年9月11日至16日举行， 在马萨诸塞州南桥。这次会议的广泛目标是两方面：首先，将 全球领先的专家研究非整倍性的后果，其次是为了纪念的贡献 Angelika Amon，Aneuploidy Research的先驱，他于2020年因卵巢癌去世。 非整倍性或染色体拷贝数状态，不是有机体正常的全数倍数 单倍完成，是恶性增长的标志，是智力的最常见遗传原因 残疾。当前基于测序的估计表明，多达90％的人类肿瘤表现出非整倍性，并且 高水平的非整倍性与转移性疾病，耐药性和患者衰退有关。 尽管非整倍性在癌症及其对人类健康的重要性，但没有规则 美国的会议致力于分享有关此类基因组改变的最新进展。 我们旨在建立有关此主题的新会议，该会议将作为论坛，以汇集科学家分享 这个令人兴奋和快速发展的领域的最新进展。这次会议的组织团队包括 领导Angelika的同事和培训的非整倍研究人员，并召集了这个就职典礼 会议在她的记忆中。该团队已经确保了FaseB在本次会议上的支持，这将 为活动提供大量的组织，逻辑和技术支持。 R13赠款资金正在 要求从代表性不足的早期研究人员和研究人员补贴成本 参加此活动的背景。我们目前在10个主题领域中有41位确认的演讲者 非整倍性和染色体分离，特别关注非整倍性对肿瘤的影响 发展与人类健康。计划为早期科学家提供其他编程，包括一系列 简短的会谈，两个海报会议和几次职业发展活动。