FASEB SRC: The Consequences of Aneuploidy: Honoring the Contributions of Angelika Amon

FASEB SRC：非整倍体的后果：纪念 Angelika Amon 的贡献

• 批准号: 10467260
• 负责人: Jason Sheltzer
• 金额: $ 3.5万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-13 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10467260
• 关键词: Address; American; Aneuploid Cells; Aneuploidy; Area; Automobile Driving; Biology; Cells; Child; Chromosomal Instability; Chromosome Segregation; Chromosomes; Clinical; Complement; DNA Sequence Alteration; Development; Disease; Down Syndrome; Drug resistance; Event; Exhibits; Extinction (Psychology); Friends; Funding; Genes; Genetic; Goals; Grant; Growth; Haploidy; Health; Human; Husband; Individual; Intellectual functioning disability; International; Logistics; Malignant - descriptor; Malignant Neoplasms; Malignant neoplasm of ovary; Massachusetts; Memory; Organism; Patient-Focused Outcomes; Physiology; Research; Research Personnel; Science; Scientist; Secure; Series; Societies; Stress; United States; Widowhood; base; career; career development; chromosome missegregation; cost; dosage; experience; member; outreach; posters; professor; symposium; tumor

Abstract We are requesting grant support for a new FASEB conference entitled “The Consequences of Aneuploidy: Honoring the Contributions of Angelika Amon.” This conference will be held from September 11th to 16th, 2022, in Southbridge, Massachusetts. The broad goals for this conference are two-fold: first, to bring together the world’s leading experts in studying the consequences of aneuploidy, and second, to honor the contributions of Angelika Amon, a pioneer of aneuploidy research who passed away from ovarian cancer in 2020. Aneuploidy, or a chromosome copy number state that is not a whole-number multiple of an organism’s normal haploid complement, is a hallmark of malignant growth and is the most common genetic cause of intellectual disability. Current sequencing-based estimates suggest that up to 90% of human tumors exhibit aneuploidy, and high levels of aneuploidy are associated with metastatic disease, drug resistance, and dismal patient outcomes. Despite the ubiquity of aneuploidy in cancer and its significance to human health, there are no regular conferences in the United States dedicated to sharing the latest advances on this class of genomic alterations. We aim to establish a new conference on this topic that will serve as a forum to bring together scientists to share the latest advances in this exciting and fast-moving field. The organizing team for this conference consists of leading aneuploidy researchers who were Angelika’s colleagues and trainees and are convening this inaugural conference in her memory. This team has already secured the support of FASEB for this conference, which will provide significant organizational, logistic, and technical support for the event. R13 grant funding is being requested to subsidize the costs for early-career researchers and researchers from under-represented backgrounds to attend this event. We currently have 41 confirmed speakers across 10 topic areas related to aneuploidy and chromosome segregation, with a particular focus on the impact of aneuploidy on tumor development and human health. Additional programming is planned for early-career scientists, including a series of short talks, two poster sessions, and several career-development events.

抽象的 我们要求为新的Faseb会议提供赠款支持，名为“非倍型的后果： 纪念安吉利卡·阿蒙（Angelika Amon）的贡献。 在马萨诸塞州南布里奇，会议的广泛目标是两个方面：首先 世界领先的专家研究非倍体的后果，其次是为了纪念 Angelika Amon，Aneuploidy Research的先驱，他于2020年因卵巢癌去世。 非整倍性或染色体拷贝数状态并非有机体正常的全数倍数 单倍体补体是恶性增长的标志，是智力的最常见遗传原因 当前基于测序的估计值表明，人类肿瘤的90％表现出 高水平的非整倍性与转移性疾病，耐药性和表现结果有关。 尽管非整倍性在癌症中无处不在，并且对人类健康具有重要意义，但没有规则 美国的会议致力于分享有关基因组改变类别的最新进展。 我们旨在建立有关该主题的新会议，该会议作为一个论坛，将科学家汇集在一起​​分享 这个令人兴奋而快速的领域的最新进步。 领导Angelika的同事和学员的非整倍研究人员，并正在召集这一就职典礼 在她的记忆中，这支球队的赛车使Faseb获得了会议的支持。 为活动提供重大的组织，逻辑和技术支持。 要求为早期研究人员和研究人员提供补贴的费用 参加此事件的背景。 非整倍性和染色体分离，特别关注肌叠型对肿瘤的影响 计划和人类健康。 简短的会谈，两个海报会议和几次职业发展活动。