Developing A Transition MicroElelectrode Array for Large-scale Brain Recording

开发用于大规模脑记录的过渡微电子电极阵列

基本信息

批准号：
10463817
负责人：
Yantao Fan
金额：
$ 22.66万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10463817
关键词：
3D Print Address Agar Aging Axon Behavior Biocompatible Materials Biodegradation Biological Biology Biomedical Engineering Biopolymers Brain Brain Mapping Brain region Cells Custom Data Development Devices Dimensions Electrodes Emotions Encapsulated Environment Failure Future Gel Goals Human Hybrids Image Immune response Implanted Electrodes In Vitro Incubators Industry Inflammatory Literature Measurement Medical Memory Methodology Microelectrodes Microfabrication Morphology Neurons Neurosciences Outcome Oxides Patients Performance Periodicity Phosphate Buffer Physiological Polymers Process Property Rattus Repeat Surgery Research Resolution Saline Signal Transduction Silicon Spectrum Analysis Stains Synapses System Technology Testing Time Tissues Utah Work base biocompatible polymer biodegradable polymer biomaterial compatibility brain computer interface brain machine interface complex biological systems density design electric impedance experimental study fluorescence imaging implantation in vitro testing in vivo innovative technologies insight mechanical properties nerve stem cell nervous system disorder neural circuit polymerization prevent prototype relating to nervous system spatiotemporal stem cells tissue phantom two-photon voltage

项目摘要

Project Summary The brain’s functions are determined by its neural circuits, which consist of approximately 85 billion neuronal cells. Current brain recording technology is not sufficient to accomplish the goal of a high resolution mapping of brain activity due to the lack of a large-scale recording technology. Another vital challenge for current brain recording technology is obtaining longer lifetime for the implanted electrodes to prevent repeated surgeries. As over time, the harsh physiological environment (wet, ionic, reactive oxidizing species, immune response, etc.) in the neural tissue breaks down and/or encapsulates the electrode implants. To overcome these obstacles, we propose to develop and validate an implantable Transition Micro- Electrode Array (tMEA) for large-scale brain recording and modulation. This approach has the potential to eventually achieve an interface density of 106 “electrodes” per cm2, which is several orders of magnitude beyond established neural recording solutions. Except for the ultra-high recording capability, radically different from existing neural technologies, the tMEA uses living neurons as means of electrical recording and its axon guiding probes will be fabricated from degradable biopolymer via 3D printing. We expect the biocompatibility of the tMEA’s unique design will greatly decrease tissue damage and may suppress inflammatory immune response in the brain. The tMEA technology will use biopolymers that degrade safely after implantation, exposing living neural stem cells that will project their axons into local brain regions to form synaptic connections with the patient’s own neurons. In this way, the biological neuronal axons grow into a stable “electrode array” and replace a failure-prone abiotic interface with natural biotic connections act as a high- performance brain-machine interface. All these distinctive features endow the tMEA with unique potential for neuroscientists and clinicians to explore human brain functions and treat neurological disease, enabling an advancement of neuroscience, medical practice, and a variety of other future technologies.

项目摘要大脑的功能取决于其神经回路，该电路约为850亿神经元细胞。当前的大脑记录技术不足以实现高分辨率的目标由于缺乏大规模记录技术而导致大脑活动的映射。另一个至关重要的挑战当前的大脑记录技术正在为植入的电子获得更长的寿命，以防止重复手术。随着时间的流逝，HARMSH物理环境（湿，离子，反应性氧化物种，免疫响应等。为了克服这些障碍，我们建议开发和验证可植入的过渡微观用于大型大脑记录和调制的电极阵列（TMEA）。这种方法有可能最终每CM2达到106个“电极”的界面密度，这是几个数量级超越已建立的神经记录解决方案。除了超高的记录能力，根本不同从现有的神经元中，TMEA使用活神经元作为电记录的手段及其轴突指导问题将通过3D打印从可降解的生物聚合物制造。我们期望的生物相容性 TMEA的独特设计将大大减少组织损伤，并可能抑制炎症免疫大脑的反应。 TMEA技术将使用在植入后安全降解的生物聚合物，暴露活着的神经干细胞，将其轴突投射到局部大脑区域以形成突触与患者自己的神经元的联系。这样，生物神经元轴突生长成稳定 “电极阵列”并用天然生物连接代替容易产生故障的非生物界面作为高性能脑机界面。所有这些独特的功能赋予TMEA具有独特的潜力神经科学家和临床医生探索人脑功能并治疗神经系统疾病，使神经科学，医学实践和其他各种未来技术的进步。