Clinical and Translational Core (Core C)

临床和转化核心（核心 C）

基本信息

批准号：
10460934
负责人：
Tamara Isakova
金额：
$ 23万
依托单位：
NORTHWESTERN UNIVERSITY AT CHICAGO
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-08-01 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10460934
关键词：
Affect American Award Bioethics Bioethics Consultants Bioinformatics Biological Markers Biological Specimen Banks Cardiovascular Diseases Cessation of life Chronic Kidney Failure Clinical Clinical Investigator Clinical Research Clinical Trials Cohort Studies Collaborations Communities Computerized Medical Record Data Data Analyses Data Collection Development Discipline End stage renal failure Ensure Environment Epidemiology Ethicists Ethics Financial Hardship Funding Goals Health Health Care Costs Healthcare Systems Human Subject Research Humanities Impairment Individual Institution Investments Kidney Kidney Diseases Lead Location Longevity Medical Methodology Methods Modality Nephrology Observational Study Outcome Participant Pathogenesis Patient Outcomes Assessments Patient Rights Patients Phenotype Physiological Pilot Projects Positioning Attribute Pre-Clinical Model Prevention Process Protocols documentation Provider Quality Control Quality of life Research Research Design Research Infrastructure Research Personnel Research Support Resources Retrieval Scientific Inquiry Security Services Speed System Talents Therapeutic Translating Translational Research Translations Universities Work adverse outcome base biobank biomedical informatics clinical translation clinically relevant community based participatory research community based research comorbidity data management data repository design ethnic diversity experience first-in-human high risk improved inclusion criteria model development multidisciplinary novel novel therapeutics patient population pre-clinical premature racial diversity research and development research study sound statistics study population therapeutic development

项目摘要

PROJECT SUMMARY TO CLINICAL AND TRANSLATION CORE Kidney diseases predispose affected individuals to high rates of end stage renal disease (ESRD), cardiovascular disease (CVD) and premature death. With nearly 30 million Americans estimated to have chronic kidney disease, the healthcare costs are tremendous. Identification of novel mechanisms for the pathogenesis of kidney diseases and related complications is urgently needed to improve adverse clinical outcomes and to reduce the financial burden on the US healthcare system. The George M. O'Brien Kidney Research Core Center at Northwestern University (NU-GoKIDNEY) will promote and support research into the discovery of novel therapeutics that will transform the prevention and treatment of kidney diseases and eventually lead to cures. The Center will join basic and clinical investigators to conduct translational research focused on the discovery of novel therapeutic modalities for patients with kidney diseases. Research catalyzed by the Preclinical Models Core and the Therapeutics Development Core will lead to discoveries of novel therapies, which will be translated into patients through the activities of the Clinical and Translational Core. The Core Leaders will work together to synergistically advance the Center’s chief goal of finding new treatments that will improve the lives of patients with kidney diseases. The Clinical and Translational Core will provide a centralized environment, essential resources and multi- disciplinary expertise to safely and ethically translate and target the discoveries identified by the Preclinical Model and Therapeutics Development Cores into the right patient population. We will efficiently connect investigators with: (1) the most appropriate components of the existing clinical research infrastructure; (2) relevant analytic experts; (3) well-matched talent in methods not commonly used in nephrology research, (4) unique data and biosample repositories; and (5) community-based research study participants and leaders in bioethics and medical humanities. Our goals are: (1) to enhance the integration of institutional strengths in clinical research; (2) to encourage cross-disciplinary collaboration within and between the Cores; (3) to introduce new disciplines into the field of kidney diseases research; (4) to improve the ability of investigators to phenotype participants through access to data and biosample repositories; and (5) to enrich the experience of study participants by enlisting involvement of bioethicists, study participants and community providers in the development of research protocols. By leveraging our strong institutional environment, existing resources and multidisciplinary expertise, the Clinical and Translational Core will accelerate the translation of preclinical discoveries into meaningful health improvements for patients with kidney diseases.

临床和翻译核心的项目摘要肾脏疾病倾向于影响个体的终阶段肾脏疾病（ESRD），心血管疾病（CVD）和过早死亡。估计有近3000万美国人慢性肾脏疾病，医疗保健费用巨大。识别新型机制迫切需要肾脏疾病的发病机理和相关并发症以改善不良临床结果并减少美国医疗保健系统的财务燃烧。乔治·奥布莱恩肾脏西北大学（NU-Gokidney）的研究核心中心将促进和支持研究进入新型疗法的发现，这将改变肾脏的预防和治疗疾病并最终导致治愈。该中心将加入基本和临床研究人员进行进行转化研究的重点是发现新型治疗方式肾脏疾病。临床前模型核心和治疗学开发催化的研究核心将导致新疗法的发现，这些疗法将通过临床和翻译核心。核心领导人将共同努力，以协同促进中心的主要目标是寻找新的治疗方法，以改善肾脏疾病患者的生活。这临床和翻译核心将提供集中的环境，基本资源和多种多样的纪律专业知识，以安全和道德的方式翻译和针对临床前确定的发现模型和治疗性发育核心核心进入合适的患者人群。我们将有效连接研究人员：（1）现有的临床研究基础设施中最合适的组成部分；（2）相关的分析专家；（3）肾脏研究不常用的方法中匹配的人才，（4）独特的数据和生物样品存储库；（5）基于社区的研究参与者和领导者生物伦理学和医学人类。我们的目标是：（1）增强机构优势的整合临床研究；（2）鼓励核心内部和之间的跨学科合作；（3）到将新学科引入肾脏疾病研究领域；（4）提高调查人员的能力通过获取数据和生物样品存储库的表型参与者；（5）丰富通过参与生物伦理学家，研究参与者和社区提供者参与研究参与者开发研究方案。通过利用我们强大的机构环境，现有资源和多学科专业知识，临床和转化核心将加速临床前的翻译发现肾脏疾病患者有意义的健康改善。