Intervention Core for the Dietary Biomarkers Development Center at Harvard University

哈佛大学膳食生物标志物开发中心的干预核心

• 批准号: 10461133
• 负责人: FRANK M SACKS
• 金额: $ 63.98万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-16 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10461133
• 关键词: Acute; Adult; Avena sativa; Behavior; Biological Markers; Biomarker of Dietary Intake; Blood; Bread; Catalogs; Chickens; Collaborations; Complement; Cotinine; Diet; Dietary Practices; Dietary intake; Disputes; Dose; Drug Kinetics; Eating; Epidemiology; Fasting; Food; Fostering; Frequencies; Goals; Grain; Health; Healthy Eating; Hospitals; Hour; Human; Institutes; Intervention; Life Style; Literature; Measurement; Measures; Methods; National Institute of Diabetes and Digestive and Kidney Diseases; Nutrient; Nutritional Study; Outcomes Research; Patient Self-Report; Plasma; Population; Population Heterogeneity; Population Study; Potato; Prevention strategy; Primary Prevention; Proteins; Public Health Schools; Questionnaires; Reporting; Research Design; Research Personnel; Resources; Sampling; Soybeans; Technology; Time; United States; United States Department of Agriculture; United States National Institutes of Health; Universities; Urine; Wheat; Work; base; beef; biomarker development; cigarette smoking; dietary; epidemiology study; feeding; food consumption; medical schools; metabolomics; novel; nutrition; population based; response; specific biomarkers; tool

ABSTRACT/SUMMARY – INTERVENTION CORE Diet is one of the most important determinants of human health and an essential component of population-wide primary prevention strategies. However, there is controversy about the quality and reliability of population- based nutrition research. Indeed, the vast majority of evidence for healthy eating is informed by large studies with dietary patterns assessed via self-report. Self-reported tools have well-recognized limitations. Plasma biomarkers have been a mainstay of epidemiologic studies. Recent advances in metabolomics technology has similarly fostered discovery of metabolites that are highly specific to intakes of foods or food groups. Metabolomics offers a tangible opportunity to identify novel metabolomic signatures for a range of foods and nutrients. However, this progress relies on the tremendous need for controlled feeding studies to identify and validate metabolites specific to each food item and group. Our objective is to establish an Intervention Core, equipped to perform tightly controlled pharmacokinetic and dose-response feeding studies across a range of food items and food groups in diverse populations. We will focus on common foods from the protein and grains food groups: (1) chicken, beef, and soybeans; and (2) whole wheat bread, potatoes, and oats. Based on our collective extensive work in nutrition metabolomics, we hypothesize that acute administration of these foods will have distinct metabolomics signatures that persist over an ensuing 24-hour period. Moreover, plasma concentrations of these metabolites will respond to the amount of the food consumed over a 6-day feeding period. Our long-term goal through these exemplar cases is to establish a rigorous and highly productive resource to the NIH, USDA, and external investigators to systematically catalog specific, reliable, and externally validated metabolomic signatures of nearly all commonly consumed foods in the United States. This proposal combines the nutrition, epidemiology, metabolomics, and feeding trials expertise of investigators at the Harvard T.H.Chan School of Public Health, the Broad Institute of Harvard and MIT, and Harvard Medical School affiliated hospitals to create a state-of-the-art nutrition-metabolomics center that will pave the way for a new era in nutrition research. Building on a long-track record of collaboration, this proposal will contribute novel, objective, metabolomic biomarkers for the characterization of diet in large population- based studies. Ultimately, this proposal answers the NIDDK and USDA’s call “for objective biomarkers of dietary intake that can serve as independent markers of dietary intake and complement current dietary intake assessment methods.”

摘要/摘要 - 干预核心 饮食是人类健康最重要的决定者之一，也是范围内人群的重要组成部分 主要预防策略。但是，关于人口的质量和可靠性存在争议 - 基于营养研究。确实，大型研究为健康饮食提供了绝大多数证据 通过自我报告评估饮食模式。自我报告的工具具有公认的局限性。 等离子体生物标志物一直是流行病学研究的中流。代谢组学的最新进展 技术类似地发现了对食物或食物摄入量高度特异的代谢产物的发现 组。代谢组学提供了一个切实的机会，可以识别一系列新型代谢组签名 食物和营养。但是，这一进展依赖于对受控喂养研究的巨大需求 识别和验证针对每个食品和组的代谢产物。 我们的目标是建立一个干预核心，能够执行严格控制的药代动力学和 跨多种食品和食品群体的剂量反应喂养研究。我们将 专注于蛋白质和谷物食品基团的常见食物：（1）鸡肉，牛肉和大豆； （2） 全麦面包，土豆和燕麦。根据我们在营养代谢组学方面的集体广泛工作，我们 假设这些食物的急性给药将具有持续存在的独特代谢组学特征 在随后的24小时内。此外，这些代谢产物的血浆浓度将对 在6天的喂养期内食用的食物量。我们通过这些示例案例的长期目标 是为NIH，USDA和外部调查人员建立严格且高产的资源 系统地分类特定，可靠和外部验证的代谢组签名 在美国，通常食用的食物。 该建议结合了营养，流行病学，代谢组学和喂养试验专家 哈佛大学T.H.集公共卫生学院的调查人员，哈佛大学和麻省理工学院广泛研究所 哈佛医学院分支机构医院，建立一个最先进的营养 - 企业代谢中心 为营养研究的新时代铺平了道路。该提议以合作的长期记录为基础上 将为大种群中的饮食表征贡献新颖，客观，代谢组生物标志物 基于研究。最终，该提议回答了NIDDK和USDA的呼吁，以“针对客观的生物标志物 饮食摄入量可以用作饮食摄入量的独立标志和完整的当前饮食摄入量 评估方法。”