Assessing Airway Smooth Muscle Tone in Asthma with Endobronchial Optical Coherence Tomography

使用支气管内光学相干断层扫描评估哮喘气道平滑肌张力

• 批准号: 10458533
• 负责人: David C Adams
• 金额: $ 18.9万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10458533
• 关键词: Address; Affect; Allergens; Allergic; Area; Asthma; Award; Biomechanics; Birefringence; Boston; Bronchoconstriction; Bronchoscopy; Cardiovascular system; Chronic Obstructive Pulmonary Disease; Clinic; Clinical; Clinical Research; Clinical assessments; Control Groups; Critical Care; Data; Development; Dimensions; Disease; Doctor of Philosophy; Environment; Esophagus; Excision; Fiber; Foundations; Functional Imaging; General Hospitals; Goals; Human; Hypertension; Image; Imaging Techniques; Impairment; Individual; International; Lead; Lung; Lung diseases; Massachusetts; Mathematics; Measurement; Measures; Medicine; Melissa; Mentors; Methodology; Modeling; Monitor; Muscle; Muscle Contraction; Muscle Tonus; Muscle function; Nature; Optical Coherence Tomography; Optics; Organ; Physics; Physiological; Physiology; Play; Population; Positioning Attribute; Research; Research Personnel; Resistance; Resources; Role; Seminal; Smooth Muscle; Structure; System; Techniques; Technology; Tissues; Training; Translating; Translational Research; Universities; Work; associated symptom; asthmatic; base; body system; career; computerized data processing; constriction; conventional therapy; experience; experimental study; human disease; imaging platform; in vivo; instructor; medical schools; motility disorder; muscular structure; novel; progenitor; pulmonary function; reduce symptoms; respiratory smooth muscle; signal processing; skills; targeted treatment; tenure track; tissue phantom; translational scientist; transmission process

Research: Asthma affects over 300 million individuals with up to an estimated 10% suffering from “treatment- resistant” asthma, for whom alternative strategies are needed. Airway smooth muscle (ASM) undergoes significant changes in asthma that increase bronchoconstriction and impair lung function. Treatments and therapies that target ASM specifically may therefore offer an alternative approach to controlling asthma, but progress is impeded by the difficulty in assessing ASM in a clinical setting. Recently we have demonstrated an imaging platform based on polarization-sensitive optical coherence tomography (PS-OCT) capable of assessing ASM distributions in vivo by exploiting the form birefringence of smooth muscle. In this proposal we are aiming to develop, validate, and implement in a pilot clinical study an extension to this technology that can be used to assess ASM function. This technology has the potential to advance not only asthma research, but research of many diseases and disorders involving smooth muscle in a number of organ systems. Candidate: David Adams, PhD is an Instructor in Medicine on the tenure track at Harvard Medical School. His long-term career goal is to become an independent translational researcher in functional imaging, focusing primarily on ASM and asthma. He has a strong background in physics, with emphasis on optics and signal processing. Since beginning postdoctoral research at Massachusetts General Hospital (MGH), he has worked on developing novel data processing techniques to maximize the utilization of data obtained with OCT imaging. The focus of this being the assessment of ASM with PS-OCT. This research will greatly benefit him in his transition to independent translational research by providing him with invaluable training in lung physiology and clinical research. Environment: Dr. Adams will train in an exceptional environment at MGH, with an abundance of resources available to help him conduct his research. His mentoring team is comprised of internationally recognized leaders in their fields: Dr. Melissa Suter, primary mentor, is a luminary in the field of translational OCT research, having been directly involved in seminal studies aimed at translating OCT imaging to the clinic. Dr. Brett Bouma, co-primary mentor, of the Wellman Center for Photomedicine at MGH is one of the key progenitors of OCT technology and translational OCT. Dr. Kenneth Lutchen, a secondary mentor, of Boston University is a pioneer in the development of experiments aimed at investigating lung physiology, and specifically ASM. Dr. Benjamin Medoff, also a secondary mentor, is chief of the Division of Pulmonary and Critical Care at MGH and a leading figure in clinical asthma research. In addition to this impressive mentoring team, Dr. Adams also has immediate access to the tremendous intellectual and collaborative opportunities available at MGH and Harvard.

研究：哮喘影响超过3亿人，估计有10％的人接受“治疗 - 抗性”哮喘，需要替代策略。气道平滑肌（ASM）经历 增加支气管收缩并损害肺功能的哮喘的显着变化。治疗和 因此，针对ASM的疗法可能会提供控制哮喘的其他方法，但 在临床环境中评估ASM的困难阻碍了进展。最近我们证明了 基于极化敏感的光学相干断层扫描（PS-OCT）的成像平台 通过利用平滑肌双折射的形式来评估体内ASM分布。在这个建议中，我们 旨在在试点临床研究中开发，验证和实施该技术的扩展 用于评估ASM功能。这项技术不仅有可能提高哮喘研究，还可以提高 对许多器官系统中涉及平滑肌的许多疾病和疾病的研究。 候选人：David Adams，PhD是哈佛医学院任职曲目的医学讲师。他的 长期职业目标是成为功能成像领域的独立翻译研究人员，专注于 首先在ASM和哮喘上。他在物理学方面有很强的背景，重点是光学和信号 加工。自从在马萨诸塞州综合医院（MGH）开始博士后研究以来，他一直在工作 开发新型数据处理技术以最大程度地利用OCT成像获得的数据。 这是用PS-OCT对ASM进行评估的重点。这项研究将极大地使他受益 过渡到独立翻译研究，通过为他提供无价的肺部生理学培训和 临床研究。 环境：亚当斯博士将在MGH的特殊环境中进行培训，并具有大量资源 可以帮助他进行研究。他的心理团队由国际公认 领导者的领导者：主要导师梅利莎·萨特（Melissa Suter）博士是Translational Oct领域 研究直接参与了旨在将OCT成像转化为诊所的第二项研究。博士 MGH的Wellman摄影医学中心的联合主要导师Brett Bouma是关键之一 OCT技术和转化OCT的祖细胞。波士顿的中学心理肯尼斯·拉奇（Kenneth Lutchen）博士 大学是旨在研究肺部生理学的实验开发的先驱， 本杰明·梅多夫（Benjamin Medoff）博士也是二级精神，是肺部和 MGH的重症监护和临床哮喘研究的主要人物。除了这种令人印象深刻的心理 团队，亚当斯博士还可以立即获得巨大的智力和协作机会 可在MGH和Harvard上市。