An Oral (Gavage) Two-Generation Reproductive Toxicity Study of Eugenol in Rats (StudyNo. 01567001)

丁子香酚对大鼠的口服（灌胃）两代生殖毒性研究（研究编号：01567001）

• 批准号: 10458333
• 负责人: William J Brock
• 金额: $ 25万
• 依托单位: AQUI-S NEW ZEALAND, LTD
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-02-01 至 2023-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10458333
• 关键词: Oral; Gavage; Two; Generation; Reproductive

An Oral (Gavage) Two-Generation Reproductive Toxicity Study of Eugenol in Rats (Study No. 01567001) Project Summary To evaluate the potential adverse effects of the test article on reproduction in a two-generation study. This will include determining the effects of the test article on male and female reproductive processes including gonadal function, estrous cyclicity, mating behavior, conception, gestation, parturition, lactation, weaning and on growth and development of the offspring. A minimum of one litter will be produced in each generation. In addition, the toxicokinetics of the test article will be examined during the study.

口服（饲料）两代生殖毒性研究大鼠（研究编号） 01567001） 项目摘要 在一项两代研究中，评估测试文章对繁殖的潜在不利影响。 这将包括确定测试文章对男性和女性生殖过程的影响 包括性腺功能，发情循环，交配行为，构思，妊娠，分娩， 后代的哺乳，断奶以及生长与发展。至少一个垃圾将是 在每一代生产。此外，将在测试文章的毒性中进行检查 研究。