Core K - Substance Use Research Core

核心 K - 药物使用研究核心

• 批准号: 10454399
• 负责人: Karsten Lunze
• 金额: $ 22.49万
• 依托单位: MIRIAM HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10454399
• 关键词: AIDS prevention; Accounting; Acquired Immunodeficiency Syndrome; Address; Adherence; Applications Grants; Basic Science; Behavior Therapy; Behavioral Sciences; Biological Testing; Boston; Cardiovascular Diseases; Caring; Cause of Death; Chronic Disease; Clinical; Clinical Research; Consultations; Consumption; Continuity of Patient Care; Data Analyses; Development; Disease Management; Drug usage; Ecological momentary assessment; Ensure; Epidemic; Ethical Issues; Ethics; Financial compensation; Functional disorder; Funding; Goals; HIV; HIV Infections; Heavy Drinking; Immunologics; Institution; Institutional Review Boards; Intervention; Interview; Knowledge; Laboratories; Leadership; Life; Liver diseases; Longitudinal Studies; Malignant Neoplasms; Manuals; Manuscripts; Medicine; Methods; Mission; Mobile Health Application; National Institute on Alcohol Abuse and Alcoholism; Neurocognitive; Neurokinin A; Outcome; Outcome Study; Patient Self-Report; Persons; Pharmacotherapy; Population; Protocols documentation; Public Health Practice; Publications; Research; Research Design; Research Personnel; Research Project Grants; Resources; Risk; Role; Services; Severities; Site; Smoking; Structure; Techniques; Testing; Training; Translational Research; Treatment outcome; Universities; Viral; Vulnerable Populations; Work; addiction; alcohol research; alcohol tobacco and other drug use; base; cocaine use; comorbidity; disability; injection drug use; innovation; mortality risk; social stigma; sound; stimulant use; substance use; tool; transmission process; treatment disparity

PROJECT SUMMARY Unhealthy substance use (SU) is a leading cause of death and disability in the US and a common comorbidity of people living with HIV (PLWH), among whom it is consistently associated with delays to engagement in HIV care, worse retention in care, lower ART adherence, and worse viral and immunologic outcomes. Therefore, HIV research must use rigorous methods to account for SU in study designs and analyses and to test SU interventions. The Substance Use Research Core (SURC) is an innovative and defining feature of the Providence/Boston Center for AIDS Research (P/B CFAR) that will catalyze innovations in SU/HIV research and strengthen the P/B CFAR's mission to address HIV in vulnerable populations. To support the development of basic, clinical, and translational research that addresses the impact of SU on the HIV epidemic, the SURC has the following Specific Aims: 1) To provide CFAR investigators expertise in developing research projects that address gaps in SU/HIV priority issues both domestically and globally. The SURC will ensure that CFAR projects appropriately consider and incorporate the impact of SU on study outcomes; connect SU investigators and HIV investigators through formal and informal opportunities to develop collaborative projects; and work with CFAR investigators to formulate innovative and scientifically sound SU/HIV research questions. 2) To support CFAR investigators in the conduct of rigorous HIV research that takes SU into account. The SURC will provide services to help investigators identify the most appropriate tools to assess consumption, severity, consequences and associated stigma of SU as well as provide training on utilization of validated self-report scales, structured interviews, laboratory and ecological momentary assessments, and biological tests of SU. The SURC has expertise on SU pharmacotherapy, behavioral interventions, mobile health (mHealth) applications, and chronic disease management. Core services in this realm will include SU intervention selection and training, fidelity assessment techniques, intervention manuals, and adaptation to new populations. The SURC will also review relevant IRB protocols and provide guidance on ethical issues of particular importance to SU research, such as confidentiality protections and providing compensation to people actively using drugs. The services provided by the SURC will ensure that CFAR investigators are optimally equipped to pursue research projects that consider and address the major impact of SU on HIV prevention, the HIV Care Continuum, and HIV comorbidities.

项目摘要 使用不健康的药物（SU）是美国的死亡和残疾的主要原因，并且是共同的合并症 患有艾滋病毒（PLWH）的人，其中与参与艾滋病毒的延迟一致 护理，在护理方面的保留率较差，较低的艺术依从性以及病毒和免疫学结果较差。因此，艾滋病毒 研究必须使用严格的方法来说明研究设计和分析中的SU并测试SU 干预措施。物质使用研究核心（SURC）是该物质的创新和定义特征 普罗维登斯/波士顿艾滋病研究中心（P/B CFAR）将催化Su/HIV研究的创新 加强P/B CFAR在弱势群体中解决艾滋病毒的使命。支持发展 基本，临床和转化研究解决了SU对HIV流行的影响，Surc具有 以下具体目的：1）为CFAR调查人员提供专业知识，以开发研究项目 在国内和全球范围内解决SU/HIV优先级问题中的差距。冲浪将确保CFAR项目 适当考虑并纳入SU对研究结果的影响；连接SU调查人员和艾滋病毒 通过正式和非正式的机会调查人员开发合作项目；并与CFAR合作 调查人员制定创新和科学声音的SU/HIV研究问题。 2）支持CFAR 进行严格的HIV研究的研究人员考虑了SU。冲浪将提供服务 帮助调查人员确定评估消费，严重性，后果和 SU的相关污名，并提供有关验证自我报告量表的利用的培训，结构化 访谈，实验室和生态瞬时评估以及SU的生物学测试。冲浪有 SU药物治疗，行为干预，移动健康（MHealth）应用和慢性的专业知识 疾病管理。该领域中的核心服务将包括SU干预选择和培训，忠诚 评估技术，干预手册和对新人群的适应。冲浪还将审查 相关的IRB协议，并为SU研究特别重要的道德问题提供指导，例如 机密性保护并为人们积极使用毒品提供赔偿。提供的服务 Surc将确保CFAR调查人员具有最佳能力从事考虑的研究项目 并解决SU对艾滋病毒预防，艾滋病毒护理连续体和艾滋病毒合并症的主要影响。