Natural environment assessment of alcohol responses in risky drinkers

危险饮酒者酒精反应的自然环境评估

• 批准号: 10452362
• 负责人: DANIEL J FRIDBERG
• 金额: $ 24.84万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-20 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10452362
• 关键词: Abstinence; Acute; Address; Adherence; Adult; Age; Alcohol abuse; Alcohol consumption; Alcohols; Anxiety; Beverages; Biosensor; Cellular Phone; Consumption; Data; Development; Dropout; Ecological momentary assessment; Enrollment; Environment; Event; Exhibits; Future; Generations; Goals; Gold; Heavy Drinking; Hour; Individual; Individual Differences; Knowledge; Laboratories; Light; Measures; Methodology; Methods; Modality; Modeling; Moods; National Institute on Alcohol Abuse and Alcoholism; Negative Reinforcements; Outcome; Participant; Patient Self-Report; Pattern; Persons; Phenotype; Placebo Control; Positive Reinforcements; Reaction Time; Reporting; Research; Research Personnel; Resolution; Resources; Rewards; Risk; Risk Factors; Role; Sedation procedure; Sensitivity and Specificity; Stress; Subgroup; Sum; Surveys; Technology; Testing; Time; Training; Work; Wrist; addiction; alcohol effect; alcohol reinforcement; alcohol related consequences; alcohol research; alcohol response; alcohol risk; alcohol use disorder; allostasis; base; binge drinking; clinically relevant; cost; drinking; drinking behavior; experience; improved; individual response; pleasure; predictive modeling; response; sedative; self reported behavior; sensor; social; theories; user-friendly; wearable sensor technology

PROJECT SUMMARY ABSTRACT Laboratory alcohol challenges have provided important knowledge about individual responses to alcohol and risk for drinking-related problems. However, this approach is time- and resource-intensive and cannot fully capture real-world alcohol responses. Therefore, the MPI propose developmental work on a method for assessing ambulatory alcohol responses that combines smartphone-based high-resolution ecological momentary assessment (HR-EMA) with new-generation, wrist-worn alcohol biosensors (BACTrack Skyn™) to provide objective verification of alcohol use. The over-arching goal of this developmental R21 proposal is to compare HR-EMA-derived real-time responses during typical heavy drinking episodes in the natural environment in individuals across the alcohol use continuum, including alcohol use disorder (AUD) drinkers, who have largely been excluded from such research, as well as heavy social drinkers (HD) and light drinker controls (LD). The proposed research will include smartphone assessments throughout a typical drinking episode in participants’ natural environment as well during a comparison non-alcohol drinking beverage consumption episode assessed at approximately the same time but on a different day. Participants will complete brief 1-minute smartphone-based surveys at multiple time points during their drinking episodes to assess their quantity consumed, subjective responses, and contextual events. They will also complete brief daily mood surveys and next-day surveys after the drinking episodes to assess carry-over effects and consequences. The noninvasive wrist-worn sensor will be used during, and for 12 hours after, each drinking episode as objective verification of self-report behavior. The study will enroll 105 participants (35/per subgroup) between ages 21-55 for participation over an approximate one-week interval. We conservatively anticipate up to a 15% drop-out rate in order to have a final N=90 participants. Our first aim is to compare acute subjective responses during alcohol drinking episodes in the natural environment across drinker subgroups. We predict that alcohol will produce higher stimulation, liking, and wanting in AUD and HD than in LD, particularly early in the drinking episode (i.e., first hour) and greater reduction in anxiety and stress in AUD versus HD and LD, after controlling for amount consumed and non-alcohol drinking episode responses. We also predict that wearable biosensors will be acceptable (≥85% use, few losses or damage) and show good sensitivity and specificity detect alcohol use vs. non-use in >90% of episodes. Our second aim is to examine individual differences in acute alcohol responses as a function of drinking pace. We predict that faster-paced alcohol consumption will be positively associated with stimulation and wanting and inversely associated with sedation, and these effects will be most pronounced in AUD vs LD, with HD intermediate. In sum, the proposed research will advance the alcohol research field by expanding HR-EMA methodologies to assess natural environment acute drinking behavior, subjective response, and drinking-related outcomes in diverse, clinically-relevant drinker subgroups.

项目摘要摘要 实验室酒精挑战提供了有关个人对酒精的反应的重要知识 与饮酒有关的问题的风险。但是，这种方法是时间和资源密集的，无法完全 捕获现实的酒精反应。因此，MPI提案的发展工作 评估结合基于智能手机的高分辨率生态的门诊酒精反应 具有新代，腕饮料生物传感器（Bactrack Skyn™）的瞬时评估（HR-EMA） 提供对酒精使用的客观验证。该发展性R21提案的整理目标是 比较自然中典型的大量饮酒情节中HR-EME的实时响应 酒精使用连续体的个人环境，包括酒精使用障碍（AUD）饮酒者， 这些研究主要被排除在此类研究之外，繁重的社交饮酒者（HD）和饮酒者 控件（LD）。拟议的研究将包括整个典型饮酒的智能手机评估 在比较非酒精饮料期间，参与者自然环境中的情节也 消费发作大约在同一时间但在不同的一天进行评估。参与者会 在饮酒剧集中，在多个时间点上完成简短的1分钟基于智能手机的调查 评估他们消耗的数量，主题响应和上下文事件。他们还将完成简介 饮酒事件之后的每日情绪调查和第二天的调查，以评估结转效果和 结果。在每次饮用的过程中，将使用无创腕部的传感器，持续12个小时 情节作为自我报告行为的客观验证。该研究将招募105名参与者（每个亚组35/） 在21-55岁之间，在一个星期的一周间隔内参与。我们保守地期待 为了获得最终n = 90名参与者的辍学率15％。我们的第一个目的是比较急性主观 在饮酒者亚组的自然环境中，自然环境中饮酒期间的反应。我们预测 与LD相比，酒精在AUD和HD中会产生更高的刺激，喜欢和想要 饮酒发作（即第一个小时），以及AUD与HD和LD的焦虑和压力的减轻， 在控制了消耗的量和非酒精饮酒剧集的响应之后。我们还预测 可穿戴生物传感器将是可以接受的（≥85％的使用，损失很少或损坏），并且表现出良好的灵敏度和 在> 90％的发作中，特异性检测酒精使用与不使用。我们的第二个目标是检查个人 急性酒精反应的差异是饮酒空间的函数。我们预测速度更快的酒精 消费将与刺激，渴望和镇静相关，与镇静相关， 在AUD VS LD中，这些影响最为明显，而HD中级。总而言之 将通过扩展HR-EMA方法来评估自然环境，推进酒精研究领域 潜水员的急性饮酒行为，主观反应和与饮酒有关的结果与临床相关 饮酒者亚组。