Effect of vibration on muscle properties, physical activity and balance in children with cerebral palsy

振动对脑瘫儿童肌肉特性、身体活动和平衡的影响

• 批准号: 10451832
• 负责人: CHRISTOPHER M MODLESKY
• 金额: $ 59.84万
• 依托单位: UNIVERSITY OF GEORGIA
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-11 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10451832
• 关键词: Address; Affect; Aftercare; Attention; Cardiovascular Diseases; Cerebral Palsy; Child; Chronic Disease; Data; Developmental Disabilities; Effectiveness; Equilibrium; Exhibits; Fatty acid glycerol esters; Flexor; Frequencies; Goals; Home; Individual; Infiltration; Intervention; Intramuscular; Laboratories; Lead; Leg; Link; Low Back Pain; Magnetic Resonance Imaging; Measures; Monitor; Muscle; Muscle Development; Neuromuscular Diseases; Non-Insulin-Dependent Diabetes Mellitus; Physical activity; Posture; Property; Public Health; Randomized Controlled Trials; Recovery; Research; Risk; Safety; System; Testing; Tissues; combat; disorder risk; effective therapy; falls; high risk; improved; innovation; muscle strength; treadmill; treatment arm; treatment strategy; vibration

PROJECT SUMMARY/ABSTRACT Cerebral palsy (CP) is a neuromuscular disorder that affects approximately 800,000 individuals in the U.S. Low muscle volume, strength and quality, poor balance and limited participation in physical activity are significant concerns in children with CP because they are strongly linked to their high risk of chronic disease. Therefore, identifying effective treatment strategies that address these issues is imperative. One treatment that has re- ceived significant attention is high-frequency, low-magnitude vibration (HLV). However, studies examining the effect of HLV on muscle development, balance and physical activity in children with CP are lacking. Our long- term goal is to identify treatments that reduce the risk of chronic disease in children with CP. The overall objective of this application is to determine the effect of a daily HLV treatment on muscle volume, strength, and quality, as well as physical activity and balance in ambulatory children with CP. Our central hypothesis is that a daily HLV treatment will increase leg muscle volume and strength, reduce leg intramuscular fat, increase physical activity and improve balance in children with CP. To test the central hypothesis, we will pursue the following aims: 1) to determine the effect of a daily HLV treatment on muscle volume and muscle strength in ambulatory children with CP; 2) to determine the effect of a daily HLV treatment on muscle quality in ambulatory children with CP; 3) to determine the effect of a daily HLV treatment on physical activity in ambulatory children with CP; and 4) to determine the effect of a daily HLV treatment on balance in ambulatory children with CP. A randomized con- trolled trial with one treatment arm will be used to accomplish the aims. Muscle volume and intramuscular fat in the leg will be assessed using magnetic resonance imaging. Muscle strength of the leg plantar flexors will be assessed using a dynamometer. Physical activity will be assessed using activity monitors. Balance will be assessed using measures of standing postural sway, as well as tests of fall recovery. HLV will be administered 10 min/d for 6 months. The proposed study is significant because children with CP have small, weak and fat- infiltrated muscles, poor balance and low physical activity which places them at a high risk for developing chronic disease. We propose an innovative intervention utilizing HLV and a comprehensive assessment of muscle prop- erties, balance and physical activity in children with CP. We expect to determine that HLV increases muscle size, strength and quality, physical activity and balance in children with CP. The results of the study will have a positive impact as they will serve as a key step toward establishing the effectiveness of HLV as treatment to combat the high risk of chronic disease in children with CP.

项目摘要/摘要 脑瘫（CP）是一种神经肌肉疾病，在美国影响约80万人 肌肉体积，力量和质量，平衡不足以及有限的体育锻炼参与很重要 CP儿童的担忧是因为他们与慢性疾病的高风险密切相关。所以， 确定解决这些问题的有效治疗策略至关重要。一种治疗 高频，低稳定振动（HLV）。但是，研究了 缺乏HLV对CP儿童肌肉发育，平衡和体育锻炼的影响。我们的长期 术语目标是确定降低CP儿童慢性疾病风险的治疗方法。总体目标 此应用是为了确定每日HLV治疗对肌肉体积，力量和质量的影响， 以及CP的门诊儿童的体育锻炼和平衡。我们的中心假设是每日HLV 治疗将增加腿部肌肉体积和强度，减少腿部肌内脂肪，增加体育锻炼 并改善CP儿童的平衡。为了检验中心假设，我们将追求以下目的：1） 确定每日HLV治疗对具有肌肉体积和肌肉力量的影响 CP; 2）确定每日HLV治疗对CP病房中肌肉质量的影响； 3）到 确定每日HLV治疗对CP病房的体育活动的影响；和4）到 确定每日HLV治疗对CP病房平衡的影响。一个随机的con- 将使用一个治疗臂进行拖钓试验来实现目标。肌肉体积和肌内脂肪 将使用磁共振成像评估腿。腿足屈肌的肌肉力量将是 使用测功机评估。体育活动将使用活动监测器进行评估。平衡将是 使用站立姿势摇摆的度量以及秋季恢复的测试进行评估。 HLV将被管理 10分钟/d 6个月。拟议的研究很重要，因为CP儿童的小，弱和脂肪 浸润的肌肉，平衡差和体育锻炼较低，使他们处于慢性发展的高风险 疾病。我们提出了利用HLV的创新干预措施，并对肌肉支持的全面评估 CP儿童的ERTIE，平衡和体育锻炼。我们希望确定HLV会增加肌肉 CP儿童的大小，力量和质量，体育锻炼和平衡。研究结果将有一个 积极影响，因为它们将成为确定HLV作为治疗效果的关键步骤 对抗CP儿童慢性病的高风险。

项目成果

Greater Visceral Fat but No Difference in Measures of Total Body Fat in Ambulatory Children With Spastic Cerebral Palsy Compared to Typically Developing Children.

• DOI: 10.1016/j.jocd.2018.09.006
• 发表时间: 2020-07
• 期刊: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
• 作者: Whitney DG;Singh H;Zhang C;Miller F;Modlesky CM
• 通讯作者: Modlesky CM

Mental health, physical activity, and sports among children with cerebral palsy.

脑瘫儿童的心理健康、身体活动和运动。

• DOI: 10.1111/cch.13122
• 发表时间: 2023
• 期刊: Child: care, health and development
• 作者: Cribb,CoryF;Keko,Mario;Creveling,Sarah;Rochani,HareshD;Modlesky,ChristopherM;Colquitt,Gavin
• 通讯作者: Colquitt,Gavin

Prefrontal cortex hemodynamic activity during a test of lower extremity functional muscle strength in children with cerebral palsy: A functional near-infrared spectroscopy study.

脑瘫儿童下肢功能性肌力测试过程中前额皮质血流动力学活动：功能性近红外光谱研究。

• DOI: 10.1111/ejn.16211
• 发表时间: 2024
• 期刊: The European journal of neuroscience
• 作者: Licea,Joel;Khan,OwaisA;Singh,Tarkeshwar;Modlesky,ChristopherM
• 通讯作者: Modlesky,ChristopherM

Statistical Models to Assess Leg Muscle Mass in Ambulatory Children With Spastic Cerebral Palsy Using Dual-Energy X-Ray Absorptiometry.

使用双能 X 射线吸收测定法评估痉挛性脑瘫门诊儿童腿部肌肉质量的统计模型。

• DOI: 10.1016/j.jocd.2018.12.004
• 发表时间: 2019
• 期刊: Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
• 作者: Zhang,Chuan;Whitney,DanielG;Singh,Harshvardhan;Slade,JillM;Shen,Ye;Miller,Freeman;Modlesky,ChristopherM
• 通讯作者: Modlesky,ChristopherM

Complicated Muscle-Bone Interactions in Children with Cerebral Palsy.

• DOI: 10.1007/s11914-020-00561-y
• 发表时间: 2020-02
• 期刊: Current osteoporosis reports
• 影响因子: 4.3
• 作者: Modlesky CM;Zhang C
• 通讯作者: Zhang C