Training in the Design and Development of Infectious Disease Therapeutics

传染病治疗药物设计和开发培训

• 批准号: 10447715
• 负责人: Richard E. Lee
• 金额: $ 22.32万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-08 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10447715
• 关键词: Communicable Diseases; Development; Therapeutic; Training; design

Project Summary/Abstract Infectious diseases remain the leading cause of death of children worldwide. New therapeutics are urgently needed to replace current treatments that are being compromised by drug resistance and emerging threats. The current COVID-19 pandemic perfectly illustrates the urgency. St. Jude Children’s Research Hospital (SJCRH) is the ideal pediatric research and treatment center to train postdoctoral fellows in this effort. The hospital’s translational and collaborative research environment combined with its expertise and infrastructure have a proven track record of successful therapeutic development. Our pediatric patients, particularly those treated for cancer, are typically immunocompromised and are at risk from a wide variety of infectious agents and pathogens that evolve more rapidly without immune clearance. SJCRH has developed an internationally recognized infectious disease program that dates from its establishment over 50 years ago. This program includes major research efforts in therapeutic and prophylactic strategies for bacterial, viral and fungal infectious agents. The training program leverages these strengths and the strong history of developing new therapeutics to provide unique and enhanced research training to postdoctoral fellows. The 16 preceptors in the program are from the departments of Infectious Diseases, Structural Biology, Chemical Biology & Therapeutics, Immunology and Pharmaceutical Sciences. They bring complementary expertise to this enterprise that not only seeks to understand the biology of infection but also strives to develop therapies to combat them. This expertise includes drug discovery, high-throughput screening, medicinal chemistry, immune responses to infection and therapies, and vaccine platforms and adjuvants. These efforts are linked to on-site best in class capabilities in GMP manufacturing and clinical trials. The broad goals of the program are to characterize pathogenic mechanisms, identify targets for therapeutic intervention, and develop vaccines and lead drug compounds that progress through the state-of-the-art therapeutics development infrastructure into safe and effective medicines. Collaborations between the preceptors provide a cross-disciplinary approach to the training program. In addition, 4 clinical collaborators will provide training in patient care, clinical trials and international medicine, and 5 training collaborators will provide training in specialized techniques. All trainees will be instructed in grant writing, rigor and reproducibility, ethics and mentoring. Interactions with pharmaceutical companies and visits to international sites in conjunction with the SJCRH Global Program are integral parts of the curriculum. To promote independence, trainees will develop their own research projects guided by a ‘team’ of mentors and apply for independent funding. We request support for three postdoctoral trainees, and the program will continue its efforts to recruit URM trainees by providing institutional support for an additional URM trainee. Finally, a formal evaluation process led by an External Advisory Committee has been established to track success and identify areas for improvement.

项目摘要/摘要 传染病仍然是全球儿童死亡的主要原因。新的治疗疗法紧急 需要替代因耐药性和新兴威胁而损害的当前治疗方法。 当前的Covid-19大流行完美地说明了紧迫性。圣裘德儿童研究医院 （SJCRH）是理想的儿科研究和治疗中心，以培训博士后研究员。 医院的翻译和协作研究环境与其专业知识和基础设施相结合 拥有成功的热发展的良好记录。我们的儿科患者，尤其是那些 接受癌症治疗的通常是免疫功能低下的，并且有多种感染剂的风险 并且病原体在没有免疫通量的情况下会更快地进化。 SJCRH在国际上发展了 公认的传染病计划可追溯到50年前的建立。这个程序 包括细菌，病毒和真菌的热和预防策略的主要研究工作 感染者。培训计划利用这些优势和发展新的历史 治疗可为博士后研究员提供独特而增强的研究培训。 16个受体 该计划来自传染病，结构生物学，化学生物学和 治疗，免疫学和药物科学。他们为此带来了完整的专业知识 不仅试图了解感染生物的企业，而且还努力开发疗法 与他们作战。该专业知识包括药物发现，高通量筛查，医学化学， 对感染和疗法以及疫苗平台和调节器的免疫反应。这些努力与 GMP制造和临床试验中最佳的课堂功能。该计划的广泛目标 要表征致病机制，识别热干预的靶标并发展 通过最先进的疗法进行的疫苗和铅药物化合物 开发基础设施为安全有效的药物。受体之间的协作 为培训计划提供跨学科的方法。此外，将有4个临床合作者提供 患者护理，临床试验和国际医学培训以及5个培训合作者将提供 专业技术培训。所有学员将被指示授予写作，严格和可重复性，道德规范 和心理。与制药公司的互动，并访问国际网站 SJCRH全球计划是课程的组成部分。为了促进独立，学员将 在“团队”指导的指导下，开发自己的研究项目，并申请独立资金。我们 要求对三名博士后学员的支持，该计划将继续努力招募URM受训者 通过为额外的URM培训生提供机构支持。最后，由一个正式的评估过程由 已经成立了外部咨询委员会来跟踪成功并确定改进领域。