Multidisciplinary Training in Molecular and Translational Rheumatology Research

分子和转化风湿病研究的多学科培训

• 批准号: 10441302
• 负责人: Joan Marie Bathon
• 金额: $ 16.86万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441302
• 关键词: Molecular; Research; Rheumatology; Training; multidisciplinary

Project Summary/Abstract This is a resubmission of a new application from the Columbia University Vagelos College of Physicians and Surgeons for a postdoctoral training program in autoimmune rheumatic diseases. The program’s mission is to train promising young rheumatologists and early career PhD investigators in the methodologies and approaches needed for scientific careers in Molecular and Translational Rheumatology. Autoimmune rheumatic diseases (ARDs) are a significant cause of morbidity and mortality, and incidence rates appear to be rising. Yet at the same time there has been a substantial and progressive decline in the number of rheumatologists choosing physician-scientist careers. Accordingly, this new T32 application will address this need by identifying highly qualified candidates for academic rheumatology careers and creating an innovative training environment that fills these needs and that builds on the considerable strengths of this research University. The proposed training is focused around three major themes, each reflecting a phase of the ARDs: 1) genetic predisposition and mechanisms; 2) pre-clinical autoimmunity; and 3) progression to clinical disease. We have engaged a superb set of primary mentors in Rheumatology and secondary mentors outside Rheumatology, many already active collaborators, who span multiple Departments and Centers and who encompass all three research themes. All of the mentors are well funded, the vast majority with NIH funding and have track records of successfully mentoring trainees to independent careers in investigation. The training period is two years in duration. Trainees will consist of Rheumatology postdoctoral fellows, as well as PhD and MD-PhD postdoctoral fellows who are committed to research in the ARDs. Funding is requested for one slot in Year 1, increasing to two slots in Years 2 and 3, and advancing to 3 slots in years 4 and 5. The training program consists of one-on-one training by the Mentor, as well as required lectures and coursework, and including optional degree coursework. A major focus of training will be on learning to bridge computational science with the biology of rheumatic diseases. This program will prepare the next generation of investigators in molecular and translational rheumatology research who will ultimately make significant contributions to our nation’s public health as independent investigators.

项目概要/摘要 这是哥伦比亚大学瓦格洛斯医学院重新提交的新申请 自身免疫性风湿病博士后培训项目的外科医生该项目的任务是： 培养有前途的年轻风湿病学家和早期职业博士研究人员的方法论和 分子和转化风湿病科学职业所需的方法。 风湿病（ARD）是发病率和死亡率的一个重要原因，发病率似乎 但与此同时，人数却在大幅下降。 因此，这个新的 T32 应用程序将解决这个问题。 通过识别风湿病学学术职业的高素质候选人并创建一个创新的团队来满足需求 满足这些需求并建立在本研究的巨大优势之上的培训环境 大学拟议的培训重点围绕三个主题，每个主题都反映了 ARD 的一个阶段： 1) 遗传倾向和机制；2) 临床前自身免疫；3) 进展为临床疾病。 我们聘请了一批优秀的风湿病学初级导师和外部二级导师 风湿病学，许多已经活跃的合作者，他们跨越多个科室和中心，并且 涵盖所有三个研究主题，所有导师都有充足的资金，其中绝大多数来自 NIH 资助。 并拥有成功指导学员从事调查独立职业的记录。 培训期限为两年，受训人员将包括风湿病学博士后研究员。 以及致力于 ARD 研究的博士和医学博士-博士后研究员。 在第 1 年请求 1 个名额，在第 2 年和第 3 年增加到 2 个名额，在第 4 年增加到 3 个名额 5. 培训计划包括导师一对一培训，以及必要的讲座和培训 课程作业，包括可选的学位课程作业，培训的主要重点是学习桥梁。 计算科学与风湿病生物学。 该计划将为分子和转化风湿病学的下一代研究人员做好准备 作为独立的研究人员最终将为我们国家的公共卫生做出重大贡献 调查人员。