The development of subnetworks of the TRN

TRN子网的发展

基本信息

批准号：
10441609
负责人：
Ubadah Sabbagh
金额：
$ 8.91万
依托单位：
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-07-15 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10441609
关键词：
Address Architecture Area BRAIN initiative Biological Clocks Biology Brain Brain region Cell Nucleus Cells Characteristics Communities Data Data Set Development Disease Dorsal Extracellular Matrix Eye Eye Movements Eye diseases Fiber Foxes Functional disorder Goals Health Human Image Immunohistochemistry In Situ Hybridization Individual Injury Interneurons Jet Lag Syndrome Knowledge Label Laboratories Lateral Geniculate Body Lead Light Mediating Medicine Mental Depression Mentors Methods Molecular Molecular Genetics Molecular Neurobiology Moods National Eye Institute Natural regeneration Nerve Regeneration Nervous system structure Neurons Neurosciences Pattern Positioning Attribute Postdoctoral Fellow Process Proteome Proteomics Publications Reporter Research Research Personnel Research Project Grants Retina Retinal Ganglion Cells Role Sleep Disorders Spatial Distribution Structure Subthalamic structure System Technical Expertise Testing Thalamic structure Training Transgenic Organisms Translational Research United States National Institutes of Health Universities Ursidae Family Viral Virginia Vision Visual Visual system structure Work cell type circadian circadian pacemaker developmental neurobiology doctoral student information processing innovation interdisciplinary approach meetings neural circuit neurochemistry neurodevelopment novel optic nerve regeneration postnatal pre-doctoral programs regenerative approach regenerative therapy restoration retinogeniculate segregation single-cell RNA sequencing tenure track therapy development tool transcriptome transcriptomics vision development visual information visual motor

项目摘要

PROJECT SUMMARY Our relationship with the visual world is heavily dependent on our ability to receive and process light coming into the eye. A portion of that light-derived information is needed for many non-image-forming visual functions like programming our biological clocks, controlling eye movement, and influencing mood. A major region of the brain which receives this non-image-forming visual information is located in the ventral thalamus and known as the ventral lateral geniculate nucleus (vLGN). Although the vLGN has connections with downstream regions involved in important functions, including visuomotor function, circadian photoentrainment, and vestibular function, it has not been well-studied. One reason for this significant gap in knowledge is that very little is known about funda- mental characteristics of vLGN, particularly with respect to its cellular and molecular landscape, thus making it technically challenging to develop tools to answer outstanding questions about its role in visual information pro- cessing. This study is motivated by the need to characterize the molecular architecture of vLGN, and to identify the neurons which form connections with retinal fibers. This project directly aligns with the BRAIN Initiative and the NIH's Blueprint Program by expanding fundamental understanding of neuroscience using innovative re- search methods to characterize cell types in the nervous system and mapping connected neurons in the brain. The results of this work will significantly impact the field and generate a deeper understanding of a visual region of the brain which receives, processes, and transmits non-image-forming visual information.

项目摘要我们与视觉世界的关系在很大程度上取决于我们接收和处理光线的能力眼睛。对于许多非图像形成的视觉功能，需要一部分光衍生的信息编程我们的生物钟，控制眼动并影响情绪。大脑的主要区域接收此非图像形成的视觉信息的，位于腹侧丘脑中，称为腹侧侧向核（VLGN）。尽管VLGN与涉及的下游区域有联系在重要功能中，包括视觉运动功能，昼夜节律光介和前庭功能，它具有没有得到充分研究。知识上这一重大差距的原因之一是，关于基础知之甚少 VLGN的心理特征，尤其是在其细胞和分子景观方面，因此使其成为在技术上具有挑战性的是开发工具，以回答有关其在视觉信息中的作用的杰出问题拖塞。这项研究是出于需要表征VLGN的分子结构的动机，并确定与视网膜纤维形成连接的神经元。该项目与大脑计划直接保持一致，并且 NIH的蓝图计划通过使用创新的重新扩展对神经科学的基本了解搜索方法以表征神经系统中的细胞类型并绘制大脑中连接的神经元。这项工作的结果将极大地影响该领域，并对视觉区域产生更深入的了解接收，过程和传输非图像形成的视觉信息的大脑。