NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing

基于 NMR 的快速流体评估：设备设计和信号处理

• 批准号: 10441674
• 负责人: Michael J Cima
• 金额: $ 58.18万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-05 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10441674
• 关键词: Affect; Algorithms; Blood Pressure; Body Weight decreased; Cardiovascular system; Cell Nucleus; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Collaborations; Custom; Data; Dehydration; Development; Device Designs; Devices; Diagnostic; Dialysis patients; Dialysis procedure; Disease; End stage renal failure; Engineering; Excision; Exercise; Extracellular Fluid; Fluid Balance; Fluid Shifts; Fluid overload; Future; Goals; Headache; Health; Heart; Hemodialysis; Hour; Human; Hypovolemia; Individual; Institutes; Intramuscular; Kidney; Kidney Diseases; Laboratories; Leg; Liquid substance; Magnetic Resonance; Magnetic Resonance Imaging; Maintenance; Measurement; Measures; Methods; Moderate Exercise; Morbidity - disease rate; Muscle; Muscle Cramp; Nature; Noise; Organ; Outcome; Participant; Patients; Physicians; Physiologic pulse; Population; Quality of Care; Quality of life; Research; Resources; Scientist; Shapes; Side; Signal Transduction; Skeletal Muscle; Soldier; Subcutaneous Tissue; Surface; Target Populations; Technology; Therapeutic; Time; Tissues; Validation; Water; Work; associated symptom; base; clinical decision-making; clinically relevant; design; experience; improved; improved outcome; in vivo; magnetic field; mobile sensor; mortality; multidisciplinary; point of care; portability; radio frequency; response; sensor; signal processing; skeletal muscle differentiation; subcutaneous; tool

NMR-Based Rapid Fluid Assessment: Device Design and Signal Processing PROJECT SUMMARY Our goal is to develop a portable, non-invasive, measurement of volume status to improve quality of life and reduce morbidity and mortality among hospitalized patients. Maintenance of euvolemic status and proper fluid balance are critical for health and improved outcomes for renal, cardiovascular, and many other disease types as well as in healthy populations prone to dehydration such as athletes and soldiers. Our laboratory has previously constructed a portable single sided magnetic resonance (MR) sensors that is capable of resolving individual fluid compartments (subcutaneous, intramuscular, etc.) within tissue. This sensor was used in a pilot clinical trial with end stage kidney disease patients. Quantitative MRI results on these patients demonstrated that the first sign of fluid overload among hemodialysis patients is an expanded skeletal muscle extracellular fluid (ECF) space. The early stage nature of the technology was evident in that study as the portable sensor could not unambiguously differentiate skeletal muscle tissue from subcutaneous tissue. The proposed research includes the design of a new portable low-field MR sensor and improved signal processing that will allow it to capture the same quantitative assessment of volume status currently achievable with quantitative MRI (qMRI). We measure local fluid distribution in the target in vivo tissue compartment. In the case of fluid volume status, our hypothesis is that a localized skeletal muscle measurement is representative of systemic fluid distribution based on results from a prior study1. The optimized sensor will have the sensitive region of the magnetic field designed to target the skeletal muscle. The existing and newly designed portable MR sensors will be used to measure intramuscular fluid distribution in end stage kidney disease patients undergoing dialysis treatment as well as in healthy athletes experiencing exercise induced fluid loss. The sensor measurement will allow for quantification of volume overload (hypervolemia) or depletion (hypovolemia) and allow for its use in clinical decision making. Dialysis patients and athletes are the target population for the following proposal. The rapid reduction in fluid volume during a dialysis session and exercise respectively provides the ideal clinical context for performing repeated fluid status measurements.

基于NMR的快速流体评估：设备设计和信号处理 项目摘要 我们的目标是开发便携式，无创的，测量数量状态以提高质量 生命并降低住院患者的发病率和死亡率。维持euvoLemic 地位和适当的流体平衡对于健康至关重要，改善肾脏的结果， 心血管以及许多其他疾病类型以及容易发生的健康人群 脱水，例如运动员和士兵。我们的实验室以前已经构建了便携式 能够解决单个流体的单面磁共振（MR）传感器 组织内的隔室（皮下，肌内等）。该传感器用于飞行员 临床试验与末期肾脏疾病患者。这些患者的定量MRI结果 证明血液透析患者中​​液体超负荷的第一个迹象是扩大 骨骼肌细胞外流体（ECF）空间。该技术的早期阶段性质是 在该研究中，显而易见的是便携式传感器，无法明确区分骨骼肌肉 来自皮下组织的组织。 拟议的研究包括设计新的便携式低场MR传感器和 改进的信号处理将使其能够捕获相同的定量评估 使用定量MRI（QMRI）可以实现的体积状态。我们测量局部流体 靶标体内组织室中的分布。在流体体积状态的情况下，我们 假设是局部的骨骼肌测量代表了全身流体 基于先前研究的结果1。优化的传感器将具有敏感的 磁场的区域旨在针对骨骼肌。现有的和新的 设计的便携式MR传感器将用于测量末端肌内流体分布 接受透析治疗以及健康运动员的肾脏疾病患者 运动诱导的液体损失。传感器测量将允许定量体积 过载（高血症）或耗竭（低血容量），并允许其在临床决策中使用 制作。透析患者和运动员是以下提案的目标人群。这 透析过程中流体体积的快速减少，分别锻炼可提供 进行重复的流体状态测量的理想临床环境。