Goodnight mouse: sleep and sepsis

晚安老鼠：睡眠和败血症

基本信息

批准号：
10438217
负责人：
Wendilywn Elizabeth Walker
金额：
$ 13.47万
依托单位：
TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-06 至 2023-09-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10438217
关键词：
Acute Admission activity Adopted Affect Agonist Antibiotics Bacteria Border Community Care given by nurses Caring Cause of Death Clinical Control Groups Critical Care Data Data Analyses Disease Doctor of Philosophy Education Electroencephalogram Electromyography Enrollment Environment Exhibits FDA approved Female First Generation College Students Foundations Functional disorder Future Hispanic Hispanic-serving Institution Hospitals Human Immune response In Vitro Infection Inflammation Mediators Inflammatory Inflammatory Response Intensive Care Units Interruption Intervention Knowledge Light Link Liquid substance Measurement Measures Medical Middle Insomnia Minority Women Modeling Modernization Mus Noise Occupations Opioid Analgesics Organ Outcome Patients Peritoneal Macrophages Persons Pharmacology Physiology Play Population Procedures Production Protocols documentation Quality of life Receptor Signaling Recovery Reporter Reporting Research Research Assistant Research Infrastructure Research Technics Research Training Role Schools Science Sepsis Serum Sleep Sleep disturbances Statistical Data Interpretation Stress Students Survivors TLR2 gene Testing Toll-like receptors Underrepresented Minority Work adequate sleep animal mortality career cecal ligation puncture clinically relevant crystalloid cytokine experience fighting graduate student improved in vivo innovation macrophage male medical schools minority student mortality novel poor sleep programs response septic patients sex skills sleep quality sleep quantity symposium training opportunity

Acute Admission activity Adopted Affect Agonist Antibiotics Bacteria Border Community Care given by nurses Caring Cause of Death Clinical Control Groups Critical Care Data Data Analyses Disease Doctor of Philosophy Education Electroencephalogram Electromyography Enrollment Environment Exhibits FDA approved Female First Generation College Students Foundations Functional disorder Future Hispanic Hispanic-serving Institution Hospitals Human Immune response In Vitro Infection Inflammation Mediators Inflammatory Inflammatory Response Intensive Care Units Interruption Intervention Knowledge Light Link Liquid substance Measurement Measures Medical Middle Insomnia Minority Women Modeling Modernization Mus Noise Occupations Opioid Analgesics Organ Outcome Patients Peritoneal Macrophages Persons Pharmacology Physiology Play Population Procedures Production Protocols documentation Quality of life Receptor Signaling Recovery Reporter Reporting Research Research Assistant Research Infrastructure Research Technics Research Training Role Schools Science Sepsis Serum Sleep Sleep disturbances Statistical Data Interpretation Stress Students Survivors TLR2 gene Testing Toll-like receptors Underrepresented Minority Work adequate sleep animal mortality career cecal ligation puncture clinically relevant crystalloid cytokine experience fighting graduate student improved in vivo innovation macrophage male medical schools minority student mortality novel poor sleep programs response septic patients sex skills sleep quality sleep quantity symposium training opportunity

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项目摘要

Abstract: Sleep plays a vital role in mammalian physiology. Adequate sleep promotes a healthy immune response, which helps the body fight infections. In the hospital setting, patient sleep is often interrupted due to nighttime nursing care, noise, and artificial light. Sepsis is the leading cause of death in US hospitals. This condition develops when an infection induces a dysregulated immune response, culminating in organ dysfunction. Despite modern medical treatments, the mortality rate for severe sepsis remains very high (30-50%). Prior reports suggest that sleep interruption exacerbates sepsis in mice, increasing animal mortality. However, the mechanisms behind these effects have not been elucidated. This proposal will confirm that sleep interruption exacerbates sepsis in mice, and determine the mechanism of this effect. The knowledge gained will create a foundation for future studies that investigate the intersection between sepsis and sleep in humans. Ultimately, septic patients may benefit from interventions to improve their sleep quantity and quality, or pharmacological interventions to reverse the effects of poor sleep. Additionally, this proposal will provide training opportunities for students enrolled in the MSc program at TTUHSC at El Paso Graduate School of Biomedical Sciences. The population of El Paso is 80% Hispanic and our MSc program enrolls a high percentage of under-represented minority students, including minority women. By participating in this project, our students will gain critical research experience, acquiring skills for in vivo and in vitro research techniques, data analysis and statistical analysis, and will gain the opportunity to present their research at a national conference. These activities will greatly enhance their career opportunities and strengthen the infrastructure of research and education at TTHSC at El Paso.

抽象的：睡眠在哺乳动物生理学中起着至关重要的作用。足够的睡眠可以促进健康的免疫反应，这有助于人体对抗感染。在医院环境中，病人的睡眠经常因夜间而中断护理，噪音和人造光。败血症是美国医院死亡的主要原因。这种情况当感染诱导免疫反应失调，最终导致器官功能障碍时发展。尽管现代医学治疗，但严重败血症的死亡率仍然很高（30-50％）。先前的报道表明，睡眠中断加剧了小鼠的败血症，从而增加了动物死亡率。然而，这些作用背后的机制尚未阐明。该建议将确认睡眠中断加剧了小鼠的败血症，并确定了这种作用的机制。知识获得了将为未来的研究创造一个基础，该研究研究败血症与人类睡眠之间的交集。最终，化粪池患者可能会受益于改善睡眠数量和质量的干预措施，或者药理学干预措施以扭转睡眠不良的影响。此外，该建议将为参加MSC计划的学生提供培训机会 El Paso生物医学研究生院的TTUHSC。埃尔帕索的人口为80％的西班牙裔，我们的MSC计划招收了包括少数民族女性在内的代表性不足的少数族裔学生中很大一部分。通过参加该项目，我们的学生将获得重要的研究经验，为In Vivo和体外研究技术，数据分析和统计分析，并将有机会呈现其在全国会议上进行研究。这些活动将极大地增加他们的职业机会和在El Paso的TTHSC加强研究和教育的基础设施。