UA Project: Advancing Vector-borne Disease Surveillance in American Indian Communities

UA 项目：推进美洲印第安人社区媒介传播疾病监测

• 批准号: 10438231
• 负责人: Dawn Heather Gouge
• 金额: $ 10.72万
• 依托单位: INTER TRIBAL COUNCIL OF ARIZONA, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2026-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10438231
• 关键词: American Indians; Communities; Disease Surveillance; Grant; Native American Research Center for Health; Vector-transmitted infectious disease

Project Summary/Abstract The Inter Tribal Council of Arizona, Cocopah Environmental Protection Office staff, medical entomologists from the University of California, vector-borne disease researchers from the University of Arizona and other community partners will build upon existing participatory research and outreach partnerships in the proposed project. Arizona often ranks amongst the highest in West Nile virus infection and related deaths relative to other states. Additionally, high populations of the invasive yellow fever mosquito Aedes aegypti in communities along southern border areas makes mosquito and pathogen surveillance critically important. Ae. aegypti is the primary vector of dengue and Zika viruses which circulate in the neighboring border states of Sonora and Baja California, Mexico. Ticks are important vectors causing human disease. Among the most significant is Rocky Mountain spotted fever (RMSF), a bacterial infection caused by Rickettsia rickettsii, which kills more people in North America than any other tickborne disease. Native American populations are disproportionately impacted. Since the first locally acquired case was identified in Arizona in 2003, the disease has become endemic in many Native American communities. In Arizona, R. rickettsii is vectored by the brown dog tick Rhipicephalus sanguineus and to date there have been more than 436 cases of RMSF with a case fatality rate of 10%, which is 15 times the national rate for this disease. There have been no surveillance efforts for vector or pathogen prevalence outside of post-epidemic events. Supportive efforts are needed to identify high-risk surveillance gaps, undertake vector and pathogen prevalence assessments, and generate access to essential infrastructure and services in the short-term. Vector-borne Disease Research Committees (VbDRC) within collaborating tribal communities will direct high priority vector surveillance and inform Tribal leadership of technical findings. Creation of Vector Risk Mitigation Plans and relevant community specific practicum training will be provided for tribal environmental health, public health and medical practitioners serving communities. Additionally, investment in Native American students through financially supported vector research experiences will help build the future public and environmental health workforce. There is strong evidence that student research experiences improve educational persistence, thus UA faculty and VbDRC members will mentor Native American students through community-based research projects.

项目摘要/摘要 亚利桑那州内部部落理事会，可可帕环境保护办公室的工作人员，医疗昆虫学家来自 加利福尼亚大学，亚利桑那大学和其他的媒介疾病研究人员 社区合作伙伴将在拟议的现有参与性研究和外展合作伙伴关系基础上进行 项目。 亚利桑那州通常是西尼罗河病毒感染和相关死亡中最高的人群。 此外，沿着社区的众多侵入性黄热蚊子埃及埃及 南部边界地区使蚊子和病原体监测至关重要。 Ae。埃及是 登革热和寨卡病毒的主要载体，它们在索诺拉和巴哈附近边界状态下流通 加利福尼亚，墨西哥。壁虱是引起人类疾病的重要媒介。最重要的是岩石 山发现热（RMSF），这是立克利克特斯（Rickettsia Rickettsii）引起的细菌感染，杀死了更多的人 北美比任何其他tick疾病。美国原住民的人口受到不成比例的影响。 由于2003年在亚利桑那州发现了第一个本地收购的病例以来，该疾病在 许多美国原住民社区。在亚利桑那州，R。Rickettsii由Brown Dog Tick Rhipicephalus培养 Sanguineus和迄今为止有436例RMSF病例，病例死亡率为10％ 是该疾病的全国率的15倍。载体或病原体没有监视工作 流行后事件以外的患病率。 需要进行支持努力以识别高风险的监视差距，进行载体和病原体 患病率评估，并在短期内访问基本基础架构和服务。 媒介传播疾病研究委员会（VBDRC）在协作部落社区中将指导高 优先矢量监视，并将部落领导层告知技术发现。媒介风险减轻的创建 将为部落环境健康，公众提供计划和相关社区特定的实践培训 卫生和医生为社区提供服务。此外，对美洲原住民的学生的投资 通过经济支持的向量研究经验将有助于建立未来的公共和环境 健康员工。有充分的证据表明，学生的研究经历改善了教育持久性， 因此，UA教职员工和VBDRC成员将通过基于社区的学生指导美国原住民学生 研究项目。