Long term stress and impairment in children and youth after an acute infectious disease outbreak: A longitudinal study of the social, familial and individual effects of Ebola viral disease (EVD)

急性传染病爆发后儿童和青少年的长期压力和损害：埃博拉病毒病（EVD）社会、家庭和个人影响的纵向研究

• 批准号: 10434902
• 负责人: Thomas M. Crea
• 金额: $ 50.72万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-23 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10434902
• 关键词: Acute; Address; Adolescent; Adult; Affect; Africa; Age; Anxiety; Area; Assessment tool; Attitude; Behavior; Behavioral Sciences; Biological Markers; Body mass index; Caregivers; Caring; Cessation of life; Child; Child Development; Childhood; Chronic; Clinical Research; Cognitive; Collaborations; Collection; Communicable Diseases; Communities; Country; Data; Data Collection; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Diagnostic Equipment; Discrimination; Disease; Disease Outbreaks; Ebola; Ebola Hemorrhagic Fever; Emotional; Environmental Impact; Epidemic; Equipment; Exposure to; Family; Family member; Goals; Government; HIV; Hair; Health; Health system; Hospitals; Hostility; Hydrocortisone; Impairment; Individual; Infection; Interdisciplinary Study; Interview; Knowledge; Lead; Longitudinal Studies; Measures; Mediating; Medical; Mental Depression; Mental Health; Motor; Outcome; Parents; Participant; Pathway interactions; Pediatrics; Personal Satisfaction; Persons; Physical Function; Positioning Attribute; Process; Psychiatry; Recording of previous events; Research; Research Methodology; Research Personnel; Retina; Risk; Sampling; Scanning; Sensory; Services; Sierra Leone; Social support; Soldier; Standardization; Stigmatization; Stress; Survivors; Symptoms; Testing; Time; Training; Virus; Virus Diseases; War; Youth; age group; aged; base; biopsychosocial; cardiovascular health; clinically significant; cohort; design; equipment training; experience; health related quality of life; improved; long-term sequelae; perceived discrimination; physical conditioning; psychologic; psychosocial; psychosocial adjustment; psychosocial wellbeing; resilience; service providers; social; social stigma; standardize measure; symptomatology; therapy development; tool

Project Abstract. The unprecedented 2013-2016 Ebola virus disease (EVD) epidemic resulted in more infections and deaths than all prior outbreaks in the 40-year history of this virus combined. Among the more than 28,000 people infected with EVD approximately 21% were children under the age of 16, and more than 16,000 children lost one or both parents during the outbreak. Prior research on chronic infectious diseases such as HIV has demonstrated lasting health, social and psychosocial outcomes. Yet, little is known about the long-term complications of EVD, or more generally, mental health and psychosocial complications related to acute infectious disease outbreaks. Our goals are to understand the physical and ecological effects on physical health, cognitive and emotional development; and to inform development of interventions that will help EVD-affected individuals achieve their full potential for healthy and productive lives. This study is guided by three Specific Aims: AIM 1: Identify ecological factors influencing processes of risk and resilience among EVD-infected, affected and unaffected children. Children and youth, aged 7-17 years, will be studied from an established cohort of EVD-infected (n=350), EVD–affected (n=350), and control (n=350) children in Sierra Leone. We will evaluate two areas: (a) Family and community acceptance, and the experience of disease stigma for those infected or affected by EVD; and (b) Psychosocial adjustment of children and caregivers by examining mental health and adaptive attitudes and behaviors. AIM 2: Identify differences in the physical health and functioning of EVD-infected, affected and unaffected children over time. We will utilize validated developmental assessment tools to identify differences among infected, affected, and control children in markers of long-term stress: (a) cognitive health and development; (b) physical health; and (c) stress presentation including collection of biomarker samples. AIM 3: Strengthen the capacity of key organizations to conduct ongoing research on vulnerable children and families' psychosocial well-being and physical health. We will partner with Sustaining Health Systems and Kenema Government Hospital to strengthen their capacities in two areas: (a) Identifying clinically significant symptomatology and creating appropriate referral pathways to services; and (b) Improving diagnostic and analytic capacity through training in research methodologies, and introduction of critically needed diagnostic equipment and training in its use.

项目摘要：2013-2016 年史无前例的埃博拉病毒病 (EVD) 疫情 造成的感染和死亡人数比 40 年历史上所有以前的疫情暴发还要多 该病毒感染者总数超过 28,000 人。 大约 21% 是 16 岁以下儿童，超过 16,000 名儿童失踪 父母一方或双方在疫情爆发期间之前对慢性传染病进行过研究。 艾滋病毒心理已表现出持久的健康、社会和社会成果。 对于埃博拉病毒病的长期并发症，或者更一般地说，精神疾病，人们知之甚少。 与急性传染病爆发相关的健康和社会心理并发症。 目标是了解物理和生态对身体健康的影响， 和情绪发展；并为制定有助于帮助的干预措施提供信息； 受埃博拉病毒病影响的个人充分发挥潜力，过上健康、富有成效的生活。 本研究以三个具体目标为指导： 目标 1：确定生态因素 影响埃博拉病毒病感染者、受影响者和未受影响者的风险和复原力过程 7-17 岁的儿童和青少年将从既定的队列中进行研究。 塞拉利昂感染埃博拉病毒病的儿童 (n=350)、受埃博拉病毒病影响的儿童 (n=350) 和对照儿童 (n=350) 的比例 我们将评估两个方面：(a) 家庭和社区的接受度，以及 埃博拉病毒病感染者或受影响者的疾病耻辱经历；以及 (b) 心理社会； 通过检查心理健康和适应态度来调整儿童和照顾者 目标 2：识别身体健康和功能的差异。 随着时间的推移，我们将利用经过验证的埃博拉病毒病感染儿童、受影响儿童和未受影响儿童。 发展评估工具来识别感染者、受影响者和受影响者之间的差异 控制儿童的长期压力标志：(a) 认知健康和发展；(b) 身体健康；(c) 压力呈现，包括生物标志物样本的收集。 目标 3：加强关键组织开展持续研究的能力 弱势儿童和家庭的心理健康和身体健康。 与可持续卫生系统和凯内马政府医院合作，加强 他们在两个领域的能力： (a) 识别具有临床意义的症状和 建立适当的服务转诊途径；以及 (b) 改进诊断和服务 通过研究方法的培训和引入的分析能力 急需诊断设备及其使用培训。

项目成果

Social distancing, community stigma, and implications for psychological distress in the aftermath of Ebola virus disease.

• DOI: 10.1371/journal.pone.0276790
• 发表时间: 2022
• 期刊: PloS one
• 影响因子: 3.7

Ebola Virus Disease Sensitization: Community-Driven Efforts in Sierra Leone.

埃博拉病毒疾病宣传：塞拉利昂社区驱动的努力。

• DOI: 10.1007/s10900-023-01265-x
• 发表时间: 2024
• 期刊: Journal of community health
• 影响因子: 5.9
• 作者: Collier,KMegan;Klein,ElizabethK;Sevalie,Stephen;Molleh,Bailah;Kabba,Yusuf;Kargbo,Abdulai;Bangura,Joseph;Gbettu,Henry;Simms,Stewart;O'Leary,Clara;Drury,Stacy;Schieffelin,JohnS;Betancourt,TheresaS;Crea,ThomasM
• 通讯作者: Crea,ThomasM