Long term stress and impairment in children and youth after an acute infectious disease outbreak: A longitudinal study of the social, familial and individual effects of Ebola viral disease (EVD)

急性传染病爆发后儿童和青少年的长期压力和损害：埃博拉病毒病（EVD）社会、家庭和个人影响的纵向研究

• 批准号: 10434902
• 负责人: Thomas M. Crea
• 金额: $ 50.72万
• 依托单位: BOSTON COLLEGE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-23 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10434902
• 关键词: Acute; Address; Adolescent; Adult; Affect; Africa; Age; Anxiety; Area; Assessment tool; Attitude; Behavior; Behavioral Sciences; Biological Markers; Body mass index; Caregivers; Caring; Cessation of life; Child; Child Development; Childhood; Chronic; Clinical Research; Cognitive; Collaborations; Collection; Communicable Diseases; Communities; Country; Data; Data Collection; Development; Developmental Delay Disorders; Diagnosis; Diagnostic; Diagnostic Equipment; Discrimination; Disease; Disease Outbreaks; Ebola; Ebola Hemorrhagic Fever; Emotional; Environmental Impact; Epidemic; Equipment; Exposure to; Family; Family member; Goals; Government; HIV; Hair; Health; Health system; Hospitals; Hostility; Hydrocortisone; Impairment; Individual; Infection; Interdisciplinary Study; Interview; Knowledge; Lead; Longitudinal Studies; Measures; Mediating; Medical; Mental Depression; Mental Health; Motor; Outcome; Parents; Participant; Pathway interactions; Pediatrics; Personal Satisfaction; Persons; Physical Function; Positioning Attribute; Process; Psychiatry; Recording of previous events; Research; Research Methodology; Research Personnel; Retina; Risk; Sampling; Scanning; Sensory; Services; Sierra Leone; Social support; Soldier; Standardization; Stigmatization; Stress; Survivors; Symptoms; Testing; Time; Training; Virus; Virus Diseases; War; Youth; age group; aged; base; biopsychosocial; cardiovascular health; clinically significant; cohort; design; equipment training; experience; health related quality of life; improved; long-term sequelae; perceived discrimination; physical conditioning; psychologic; psychosocial; psychosocial adjustment; psychosocial wellbeing; resilience; service providers; social; social stigma; standardize measure; symptomatology; therapy development; tool

Project Abstract. The unprecedented 2013-2016 Ebola virus disease (EVD) epidemic resulted in more infections and deaths than all prior outbreaks in the 40-year history of this virus combined. Among the more than 28,000 people infected with EVD approximately 21% were children under the age of 16, and more than 16,000 children lost one or both parents during the outbreak. Prior research on chronic infectious diseases such as HIV has demonstrated lasting health, social and psychosocial outcomes. Yet, little is known about the long-term complications of EVD, or more generally, mental health and psychosocial complications related to acute infectious disease outbreaks. Our goals are to understand the physical and ecological effects on physical health, cognitive and emotional development; and to inform development of interventions that will help EVD-affected individuals achieve their full potential for healthy and productive lives. This study is guided by three Specific Aims: AIM 1: Identify ecological factors influencing processes of risk and resilience among EVD-infected, affected and unaffected children. Children and youth, aged 7-17 years, will be studied from an established cohort of EVD-infected (n=350), EVD–affected (n=350), and control (n=350) children in Sierra Leone. We will evaluate two areas: (a) Family and community acceptance, and the experience of disease stigma for those infected or affected by EVD; and (b) Psychosocial adjustment of children and caregivers by examining mental health and adaptive attitudes and behaviors. AIM 2: Identify differences in the physical health and functioning of EVD-infected, affected and unaffected children over time. We will utilize validated developmental assessment tools to identify differences among infected, affected, and control children in markers of long-term stress: (a) cognitive health and development; (b) physical health; and (c) stress presentation including collection of biomarker samples. AIM 3: Strengthen the capacity of key organizations to conduct ongoing research on vulnerable children and families' psychosocial well-being and physical health. We will partner with Sustaining Health Systems and Kenema Government Hospital to strengthen their capacities in two areas: (a) Identifying clinically significant symptomatology and creating appropriate referral pathways to services; and (b) Improving diagnostic and analytic capacity through training in research methodologies, and introduction of critically needed diagnostic equipment and training in its use.

项目摘要。前所未有的2013-2016埃博拉病毒病（EVD）流行病 与40年历史上所有以前的暴发相比，导致感染和死亡更多 该病毒合并。在感染EVD的28,000多人中 大约21％的儿童在16岁以下，超过16,000名儿童失去了 爆发期间的一个或两个父母。先前关于慢性传染病的研究 例如艾滋病毒表现出持久的健康，社会和社会心理成果。然而， 关于EVD的长期并发症或更普遍的心理并发症知之甚少 与急性传染病暴发有关的健康和社会心理并发症。我们的 目标是了解物理和生态学对身体健康，认知的影响 和情感发展；并告知开发干预措施，以帮助 受EVD影响的人充分发挥健康和产品生活的潜力。 这项研究以三个特定目的为指导：目标1：确定生态因素 影响EVD感染，受影响和不受影响的风险和韧性过程 孩子们。 7-17岁的儿童和青年将从一个既定的队列中进行研究 EVD感染（n = 350），EVD影响（n = 350）和对照（n = 350）儿童 利昂。我们将评估两个领域：（a）家庭和社区接受，以及 受EVD感染或影响的人的疾病污名经验； （b）社会心理 通过检查心理健康和适应性参与者来调整儿童和照料者 和行为。目标2：确定身体健康和功能的差异 随着时间的流逝，EVD感染，受影响和未受影响的儿童。我们将利用经过验证的 发育评估工具，以识别受感染，受影响和 长期压力标记中的对照儿童：（a）认知健康和发展； （b） 身体健康； （c）应力表现，包括收集生物标志物样品。 目标3：增强关键组织进行持续研究的能力 脆弱的儿童和家庭的社会心理健康和身体健康。我们将 与维持卫生系统和Kenema政府医院合作以加强 它们在两个领域的能力：（a）确定临床上显着的症状学和 为服务创建适当的推荐途径； （b）改善诊断和 通过研究方法培训的分析能力，并引入 急需的诊断设备和使用培训。

项目成果

Social distancing, community stigma, and implications for psychological distress in the aftermath of Ebola virus disease.

• DOI: 10.1371/journal.pone.0276790
• 发表时间: 2022
• 期刊: PloS one
• 影响因子: 3.7

Ebola Virus Disease Sensitization: Community-Driven Efforts in Sierra Leone.

埃博拉病毒疾病宣传：塞拉利昂社区驱动的努力。

• DOI: 10.1007/s10900-023-01265-x
• 发表时间: 2024
• 期刊: Journal of community health
• 影响因子: 5.9
• 作者: Collier,KMegan;Klein,ElizabethK;Sevalie,Stephen;Molleh,Bailah;Kabba,Yusuf;Kargbo,Abdulai;Bangura,Joseph;Gbettu,Henry;Simms,Stewart;O'Leary,Clara;Drury,Stacy;Schieffelin,JohnS;Betancourt,TheresaS;Crea,ThomasM
• 通讯作者: Crea,ThomasM