Cell Identity and Signaling (CIS)

细胞识别和信号传导 (CIS)

基本信息

批准号：
10434760
负责人：
Ourania M. Andrisani
金额：
$ 2.82万
依托单位：
PURDUE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1998
资助国家：
美国
起止时间：
1998-05-08 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10434760
关键词：
Address Animal Cancer Model Animal Model Arabidopsis Award Bioinformatics Biological Models Biometry Cancer Cell Growth Cancer Center Support Grant Cancer Model Cancer Research Project Cell Culture Techniques Cell physiology Cells Cellular biology Computational Biology Development Drosophila genus Drug Delivery Systems Drug Design Drug resistance Embryonic Development Epigenetic Process Extramural Activities Fostering Foundations Funding Future Gene Expression Genes Genetic Genomics Goals Grant Journals Knowledge Laboratories Laboratory Research Link Malignant Neoplasms Malignant neoplasm of brain Malignant neoplasm of liver Malignant neoplasm of lung Malignant neoplasm of pancreas Malignant neoplasm of prostate Metabolic Mission Modeling Modernization Molecular NCI Center for Cancer Research Nature Neoplasm Metastasis Paper Pathogenesis Pathway interactions Peer Review Process Productivity Program Research Project Grants Publications Publishing Purdue Cancer Center Research Research Personnel Research Support Resource Sharing Scientific Advances and Accomplishments Signal Transduction Strategic Planning Technology Training Tumor Immunity Validation Yeasts Zebrafish base biomarker development cancer cell cancer genomics cancer recurrence cancer stem cell cell growth cell growth regulation college drug discovery inter-institutional liposarcoma malignant breast neoplasm member mouse model novel nutrition prevent programs structural biology targeted treatment therapeutic development therapy resistant tool transcriptomics

项目摘要

Cell Identity and Signaling (CIS) Research Program Project Summary The key scientific goals of the Cell Identity and Signaling (CIS) Research Program are to advance discovery of novel molecular mechanisms of cell identity and cell signaling, to apply this knowledge towards understanding cancer pathogenesis, and to use this knowledge to develop novel, mechanism-based approaches to prevent or interfere with cancer cell growth, aiming for cancer solutions. It is well-established that cancer cells hijack normal regulation of cell growth, differentiation, and embryonic development, via genetic and epigenetic mechanisms. The CIS Program aims to understand these fundamental mechanisms and shepherd them toward cancer solutions. The CIS Program has 27 members, $5.5 million in cancer-focused, peer-reviewed extramural funding, with 38% of the total funding from the NCI. CIS research themes span a spectrum from basic discovery, using simple model organisms and cellular and animal cancer models, to cancer solutions. CIS members are highly productive with 202 cancer-related publications since July 2015, and highly interactive with a 70% increase in collaborative publications. Importantly, 73% of all cancer-relevant CIS publications are collaborative. In the previous funding cycle, the CIS Program, supported by competitive pilot grants from the Purdue Center for Cancer Research (PCCR), successfully fostered highly collaborative, cancer-relevant studies linking CIS Program themes (intra- programmatic) with other PCCR programs (inter-programmatic), and also with external partners (inter- institutional). For the next funding period, the goal of the CIS Program is to advance the breadth and depth of our understanding of cancer-relevant mechanisms and to maximize their transition to cancer solutions. The approach towards this goal is to enable and foster collaborative and transdisciplinary studies by providing competitive PCCR pilot grants, and access to state-of-the-art, PCCR-supported Shared Resources, and modern technology in structural biology, drug discovery, cancer genomics, bioinformatics and computational biology. Three specific aims are proposed. Aim 1: To further enhance discovery of basic and cancer-relevant mechanisms by strengthening the integration of computational genomics and bioinformatics and increasing expertise and training in computational biology. Aim 2: To enhance discovery of cancer-relevant mechanisms of signal transduction, gene expression and epigenetics by supporting collaborative, transdisciplinary approaches and modern technologies. Aim 3: To accelerate transition of newly discovered cancer-relevant mechanisms towards cancer solutions, by developing essential mechanisms as therapy targets, and by employing transdisciplinary approaches.

细胞识别和信号转导 (CIS) 研究计划项目概要细胞识别和信号转导 (CIS) 研究计划的关键科学目标是推进发现细胞身份和细胞信号传导的新分子机制，将这些知识应用于理解癌症发病机制，并利用这些知识开发新的、基于机制的方法来预防或干扰癌细胞生长，旨在寻找癌症解决方案。众所周知，癌细胞劫持正常细胞通过遗传和表观遗传机制调节细胞生长、分化和胚胎发育。 CIS 项目旨在了解这些基本机制并引导它们走向癌症解决方案。 CIS 计划有 27 名成员，提供 550 万美元的针对癌症、经过同行评审的外部资金，其中总资金的38%来自NCI。 CIS 研究主题涵盖从基本发现到使用简单的模型生物体以及细胞和动物癌症模型，直至癌症解决方案。 CIS 成员生产力高自 2015 年 7 月以来，已发表 202 篇癌症相关出版物，互动性强，协作量增加了 70% 出版物。重要的是，73% 的癌症相关 CIS 出版物都是合作发表的。在之前的融资中周期，CIS 计划，由普渡大学癌症研究中心竞争性试点资助支持 (PCCR)，成功地促进了高度协作的、与癌症相关的研究，将 CIS 计划主题联系起来（内部程序化）与其他 PCCR 程序（程序间）以及外部合作伙伴（程序间）机构）。对于下一个资助期，CIS 计划的目标是推进我们的研究广度和深度了解癌症相关机制并最大限度地向癌症解决方案过渡。方法实现这一目标的目标是通过提供有竞争力的研究来实现和促进协作和跨学科研究 PCCR 试点拨款，以及获得 PCCR 支持的最先进的共享资源和现代技术结构生物学、药物发现、癌症基因组学、生物信息学和计算生物学。三具体提出了目标。目标 1：通过以下方式进一步加强基本和癌症相关机制的发现：加强计算基因组学和生物信息学的整合，增加专业知识和培训在计算生物学中。目标 2：加强癌症相关信号转导机制的发现，通过支持协作、跨学科方法和现代方法来研究基因表达和表观遗传学技术。目标3：加速新发现的癌症相关机制向癌症的转变解决方案，通过开发基本机制作为治疗目标，并采用跨学科接近。