Characterizing the effects of family history of alcoholism on alcohol analgesia

描述酒精中毒家族史对酒精镇痛的影响

• 批准号: 10434712
• 负责人: Michael E ROBINSON
• 金额: $ 47.6万
• 依托单位: UNIVERSITY OF FLORIDA
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-05 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10434712
• 关键词: Absence of pain sensation; Acute; Acute Pain; Address; Affect; Affective; Alcohol consumption; Alcoholism; Alcohols; American; Amygdaloid structure; Analgesics; Anterior; Behavior; Biological; Brain; Chronic; Clinical; Cognitive; Data; Expectancy; Family; Family history of; Feeling; Goals; Health; Hypothalamic structure; Image; Individual; Insula of Reil; Intake; Intuition; Knowledge; Medial; Modeling; Moods; Motivation; Musculoskeletal Pain; Negative Reinforcer; Neurobiology; Neurotransmitters; Nucleus Accumbens; Opioid; Opioid Analgesics; Opioid agonist; Oral; Pain; Pain-Free; Patients; Personality; Pharmacology; Placebo Effect; Prefrontal Cortex; Quality of life; Recording of previous events; Reporting; Research; Risk; Risk Behaviors; Role; Self Administration; Self Medication; Self-Injurious Behavior; Sex Differences; Somatosensory Cortex; Stimulus; Structure; Subgroup; System; Testing; Thalamic structure; Tissues; Woman; Work; addiction; alcohol effect; alcohol response; alcohol sensitivity; alcohol use disorder; base; biopsychosocial; chronic pain; chronic pain management; chronic pain patient; cingulate cortex; conditioning; cost; drinking; efficacious treatment; expectation; experience; improved; interest; medical attention; men; neural correlate; neuromechanism; oral pain; pain chronification; pain processing; pain reduction; pain relief; pain sensitivity; psychologic; response; sex

Project Summary Pain is the most common reason that patients seek medical attention. Acute pain is an essential indicator of current or impending tissue damage. However, chronic pain is a maladaptive state with strong affective, biological, and psychological components. Chronic pain is extremely costly and has strong negative effects on sufferers’ quality of life. Existing treatments for chronic pain, including opioid analgesics, are relatively ineffective. Perhaps as a result of the lack of efficacious treatments, it has been recently reported that nearly 25% of individuals suffering from chronic oral and/or musculoskeletal pain self-medicate through the oral consumption of alcohol. Indeed, alcohol interacts with a wide range of relevant pharmacologic targets capable of modulating the experience of pain. However, the biological mechanisms underlying this intuitive interaction are not well established. This relationship is important to understand because alcohol analgesia may act as a potent negative reinforcer for alcohol intake, which, in turn, can have adverse health effects by increasing risk of developing an alcohol use disorder. Familial risk for alcoholism, along with sex and certain mood/personality factors, may act as critical modulators of individual sensitivity to alcohol analgesia. However, it is currently unclear whether this sensitivity is the result of neurobiological, and/or learned factors. By characterizing independent contributions of each of these factors, this proposal will improve understanding of the interplay between pain/alcohol sensitivity, sex, and family history of alcoholism as a modulator of sensitivity to alcohol analgesia. These efforts will inform further research and clinical/translational efforts regarding risk associated with self-medication of pain by consuming alcohol. Critically, the impact of these factors on the functional neural correlates of alcohol analgesia will also be determined, improving mechanistic understanding of alcohol analgesia.

项目摘要 疼痛是患者寻求医疗护理的最常见原因。急性疼痛是必不可少的指标 电流或即将发生的组织损伤。但是，慢性疼痛是一种不良适应状态，情感强烈， 生物学和心理成分。慢性疼痛非常昂贵，对 患者的生活质量。现有的慢性疼痛治疗，包括阿片类镇痛药，是相对的 无效。也许由于缺乏有效的治疗，最近有报道称 患有慢性口腔和/或肌肉骨骼疼痛自我治疗的人中有25％通过口服 饮酒的消费。实际上，酒精与能够的各种相关药物靶标相互作用 调节疼痛的经历。但是，这种直观相互作用的生物学机制 没有很好地确定。这种关系对于理解很重要，因为酒精镇痛可能充当 有效的对酒精摄入的负面增强器，反过来又会通过增加风险而产生不利的健康影响 发展饮酒障碍。家族性酗酒的风险，以及性别和某些心情/个性 因素可以充当对酒精镇痛敏感性的关键调节剂。但是，目前是 尚不清楚这种敏感性是否是神经生物学和/或学习因素的结果。通过表征 这些因素的独立贡献，该提案将改善对互动的理解 在疼痛/酒精敏感性，性别和酒精中毒家族史之间作为对酒精敏感的调节剂 镇痛。这些努力将为相关风险的进一步研究和临床/翻译工作提供信息 通过食用酒精来自我治疗疼痛。至关重要的是，这些因素对功能的影响 还将确定酒精镇痛的神经相关性，从而提高对酒精的机械理解 镇痛。

项目成果

Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake.

• DOI: 10.1038/s41598-023-34546-5
• 发表时间: 2023-05-05
• 期刊: Scientific reports
• 影响因子: 4.6

Acute Alcohol Intake Produces Widespread Decreases in Cortical Resting Signal Variability in Healthy Social Drinkers.

• DOI: 10.1111/acer.14381
• 发表时间: 2020-07
• 期刊: Alcoholism, clinical and experimental research
• 作者: Sevel L;Stennett B;Schneider V 2nd;Bush N;Nixon SJ;Robinson M;Boissoneault J
• 通讯作者: Boissoneault J

Simultaneous edited MRS of GABA, glutathione, and ethanol.

同时编辑 GABA、谷胱甘肽和乙醇的 MRS。

• DOI: 10.1002/nbm.4227
• 发表时间: 2020
• 期刊: NMR in biomedicine
• 影响因子: 2.9
• 作者: Saleh,MuhammadG;Wang,Min;Mikkelsen,Mark;Hui,SteveCN;Oeltzschner,Georg;Boissoneault,Jeff;Stennett,Bethany;Edden,RichardAE;Porges,EricC
• 通讯作者: Porges,EricC

Acute Tolerance to the Analgesic Effects of Alcohol.

对酒精镇痛作用的急性耐受。

• DOI: 10.15288/jsad.2021.82.422
• 发表时间: 2021
• 期刊: Journal of studies on alcohol and drugs
• 影响因子: 3.4
• 作者: Williams,MichelleK;Vitus,Darya;Ferguson,Erin;Stennett,Bethany;Robinson,Michael;Boissoneault,Jeff
• 通讯作者: Boissoneault,Jeff

Sex differences in associations between delay discounting and expectancies for alcohol analgesia.

• DOI: 10.1037/pha0000517
• 发表时间: 2022-12
• 期刊: Experimental and clinical psychopharmacology
• 影响因子: 2.3
• 作者: Ferguson E;Vitus D;Williams M;Anderson M;LaRowe L;Ditre JW;Stennett B;Boissoneault J
• 通讯作者: Boissoneault J