Effects of Music Training on Neurodevelopment and Associated Health Outcomes

音乐训练对神经发育和相关健康结果的影响

基本信息

批准号：
10432713
负责人：
Assal Habibi
金额：
$ 56.94万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-09-01 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10432713
关键词：
Address Adherence Adult Affective Age Anterior Arts Auditory Behavioral Books Brain Child Clinical Communities Complex Control Groups Correlation Studies Cross-Sectional Studies Cultural Diversity Development Exhibits Feasibility Studies Focus Groups Foundations Functional Magnetic Resonance Imaging Future Goals Health Hispanic Home environment Image Individual Intervention Intervention Studies Intervention Trial Investigation Lead Life Light Low income Measurement Measures Motivation Motor Motor Cortex Motor Skills Multimodal Imaging Music Neuronal Plasticity Obesity Outcome Outcome Study Participant Phase Play Population Prefrontal Cortex Process Prospective Studies Randomized Randomized Controlled Trials Regulation Reporting Research Personnel Rewards Role Sampling Schools Selection Bias Services Signal Transduction Societies Socioeconomic Status Structure Students Suggestion System Testing Time TimeLine Training Training Programs Visual system structure Work Youth after-school program base behavior change behavior measurement brain behavior brain circuitry cingulate cortex cognitive function cohort community involvement computerized cost effective design early adolescence ethnic minority feasibility testing high risk middle childhood minority children musician neural recruitment neurodevelopment neuroimaging novel strategies primary endpoint primary outcome programs recruit response retention rate secondary outcome sensory system somatosensory success trial design underserved community

项目摘要

Project Summary While there is a growing body of evidence suggesting that music training benefits brain development, the evidence is not conclusive and rigorously designed randomized control trial (RCT) neuroimaging studies are needed to provide a definitive answer to whether and which brain circuits are enhanced by music training and how. We aim to address this gap: we propose an RCT to robustly test the hypothesis that systematic music training will benefit development of brain inhibition control circuitry among Hispanic youth from underserved communities. Prior work including ours provided suggestive evidence that long-term music training in children may lead to neuroplastic functional changes in the associated frontal brain circuitry and improvement of inhibitory control. During the R61 phase, we will test the feasibility (recruitment, retention, adherence and intent to continue) of a RCT on 40 Hispanic children between ages 6-8, of whom will be assigned to a 24-month intervention trial targeting community and group-focused after school music training (MG) or to an after-school program comprising arts, book clubs, ethnic and culture studies without specific focus on systematic music training, the control group (CG). We will use multi-modal imaging and behavioral probes to measure two aspects of inhibition control: (1) response inhibition by using a stop-signal task and (2) delayed gratification using a computerized task wherein children will be asked to choose immediate vs. delayed monetary rewards. Neuroimaging measures will be obtained twice, pre and post 2-yr intervention. Behavioral measures will be obtained at baseline and yearly thereafter. During the R33 phase, we will additionally recruit 74 Hispanic children between ages 6-8 and assess them with the same imaging and behavioral measurements using the same testing timeline as in R61. This is the first RCT using neuroimaging to assess whether and how music training enhances brain inhibition control circuitry. By focusing on Hispanic children from underserved communities our results will shed light on the effects of music training on development of brain function. And early life brain-to-behavior changes induced by music training may have long-term positive effects on an individual's health and success.

项目概要虽然越来越多的证据表明音乐训练有益于大脑发育，但证据还不是决定性的，需要严格设计的随机对照试验 (RCT) 神经影像学研究来提供明确的答案：音乐训练是否可以增强大脑回路以及哪些大脑回路可以通过音乐训练得到增强以及如何。我们的目标是解决这一差距：我们提出了一项随机对照试验来有力地检验这样一个假设：系统的音乐训练将有利于来自服务不足社区的西班牙裔年轻人大脑抑制控制电路的发展。包括我们在内的先前工作提供了提示性证据，表明儿童的长期音乐训练可能会导致相关额叶脑回路的神经可塑性功能变化和抑制控制的改善。在 R61 阶段，我们将对 40 名 6-8 岁的西班牙裔儿童进行随机对照试验（RCT）的可行性（招募、保留、坚持和继续意愿），其中将被分配到针对社区和群体的为期 24 个月的干预试验-专注于课后音乐培训（MG）或包括艺术、读书俱乐部、民族和文化研究的课后计划，但不特别注重系统音乐培训，对照组（CG）。我们将使用多模态成像和行为探针来测量抑制控制的两个方面：（1）通过使用停止信号任务来抑制反应，（2）使用计算机化任务来延迟满足，其中儿童将被要求选择立即与停止信号任务。延迟金钱奖励。神经影像学测量将在两年干预前和干预后进行两次。行为测量将在基线时以及此后每年进行。在 R33 阶段，我们将另外招募 74 名 6-8 岁的西班牙裔儿童，并使用与 R61 相同的测试时间表，通过相同的成像和行为测量对他们进行评估。这是第一个使用神经影像学来评估音乐训练是否以及如何增强大脑抑制控制电路的随机对照试验。通过关注来自服务不足社区的西班牙裔儿童，我们的研究结果将揭示音乐训练对大脑功能发展的影响。音乐训练引起的生命早期大脑到行为的变化可能对个人的健康和成功产生长期的积极影响。