Basic Science Core - Animal models

基础科学核心 - 动物模型

基本信息

批准号：
10431469
负责人：
Shannan Hall-Ursone
金额：
$ 19.99万
依托单位：
TEXAS BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-03-10 至 2027-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10431469
关键词：
Address Animal Experimentation Animal Model Animals Basic Science Biomedical Research Chest Cities Clinic Clinical Clinical Management Clinical Services Communicable Diseases Communities Complement Country Data Development Discipline Drug Screening Ebola Experimental Designs Foundations Funding Agency HIV Health Health Professional Hepatitis Viruses Human In Vitro Inpatients Institutes Knowledge Leadership Mexico Mission Modeling Molecular Biology Mus Outpatients Participant Pathogenesis Pertussis Primates Publishing Research Research Institute Research Personnel Research Training Resources Rodent Science Structure System Testing Texas Training Training Programs Translating Tuberculosis Tuberculosis Vaccines Universities Work ZIKA biocontainment facility design experience experimental study externship imaging platform in silico metropolitan mouse model multidisciplinary next generation nonhuman primate novel therapeutics novel vaccines peer prevent programs prospective skills success theories tool

项目摘要

IN-TRAC ANIMAL CORE ABSTRACT The Animal Model Core will establish a training program to introduce all IN-TRAC participants to the TB field using a variety of animal models that can translate in silico and in vitro findings into potential application to humans. Texas Biomed hosts the Southwest National Primate Research Center (SNPRC) and has developed large NHP programs that incorporate aerobiology, molecular biology and a variety of imaging platforms within the Animal Biosafety Level 3 (ABSL3). These will be the foundation of the Animal Core. SPECIFIC AIM 1: Conduct an educational program in the use of animals for research, and alternatives. The use of animals in research requires consideration of the three R’s (reduction, replacement, refinement). All IN-TRAC participants will receive training in the considerations of the three R’s during experimental design, selection of appropriate models to test their specific hypothesis, and the alternate systems available or in development for the replacement of animals in biomedical research. SPECIFIC AIM 2: Leveraging the mouse model of TB to study pathogenesis and testing of new therapies and vaccines. The mouse model has been a mainstay for TB research and remains a useful tool for understanding TB immuno-pathogenesis and for screening drugs and vaccines for TB. IN-TRAC participants will be introduced to a variety of mouse resources available for TB research, and will be trained in theory and practice of how to design and conduct studies using rodents, and how to interpret experimental data with scientific rigor. SPECIFIC AIM 3: Leveraging the NHP model of TB to study pathogenesis and testing of new therapies and vaccines. Texas Biomed has a unique resource in the SNPRC that can provide IN-TRAC participants with an in depth training in the use of NHPs in TB research. IN- TRAC participants will be introduced to a variety of NHP resources available for TB research, and train in theory and practice of how to design and conduct studies using NHPs, and how to interpret experimental data with scientific rigor. At the completion of the Animal Model Core, participants will be able to effectively interpret published data that use rodents and NHP (and other animal models, in part through externships), design experiments to test their own hypothesis, and participate in TB research that uses animals.

痕迹动物核心摘要动物模型核心将建立一个培训计划，将所有跟踪参与者介绍到结核病领域使用各种可以在硅和体外发现中转化为潜在应用到的动物模型人类。德克萨斯州Biomed主持西南国家灵长类动物研究中心（SNPRC），并已开发大型NHP计划，其中包含有机生物学，分子生物学和各种成像平台动物生物安全3级（ABSL3）。这些将是动物核心的基础。具体目标1：在使用动物进行研究和替代方案中进行教育计划。动物的使用在研究中需要考虑三个R（还原，替换，改进）。所有跟踪参与者在实验设计期间，将接受三个R的考虑，选择合适的培训测试其特定假设的模型，以及可用或开发的替代系统在生物医学研究中取代动物。特定目标2：利用结核病的鼠标模型研究新疗法和疫苗的发病机理和测试。鼠标模型一直是结核病研究，仍然是理解结核病免疫致病发生以及筛查药物和的有用工具结核病的疫苗。 TRAC参与者将被介绍到可用于结核病的各种鼠标资源研究，并将接受有关如何使用啮齿动物设计和进行研究的理论和实践培训用科学严格解释实验数据。特定目的3：利用结核病的NHP模型研究新疗法和疫苗的发病机理和测试。德克萨斯州BioMed具有独特的资源 SNPRC可以为TRAC参与者提供在TB研究中使用NHP的深入培训。在- TRAC参与者将被引入各种用于结核病研究的NHP资源，并在理论上进行培训以及如何使用NHP设计和进行研究的实践，以及如何使用科学严谨。动物模型核心完成时，参与者将能够有效解释已发布的数据使用啮齿动物和NHP（以及其他动物模型，部分通过实习），设计测试自己的假设的实验，并参与使用动物的结核病研究。