Purchase of a SARRP 200 Platform for Irradiation

购买 SARRP 200 辐照平台

• 批准号: 10430904
• 负责人: Maureen E. Murphy
• 金额: $ 60万
• 依托单位: WISTAR INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10430904
• 关键词: Advisory Committees; Animals; Biomedical Research; Bone Marrow Purging; COVID-19 vaccine; Cancer Biology; Cells; Cesium; Faculty; Floor; Funding; Human; Human Resources; IACUC; Imaging Device; Immune system; Immunocompromised Host; Immunology; Institutes; Laboratory Animals; Medical; Monoclonal Antibody Therapy; Mus; Pennsylvania; Philadelphia; Physics; Procedures; Radiation; Radiation Oncology; Recording of previous events; Request for Applications; Research; Research Institute; Research Personnel; Roentgen Rays; System; Techniques; The Wistar Institute; Training; United States; Universities; Vaccines; Whole-Body Irradiation; animal facility; cone-beam computed tomography; experience; humanized mouse; image guided radiation therapy; instrument; irradiation; programs; research clinical testing; success; synergism

Project Summary This application requests funds for a stand-alone precision x-ray irradiator and imaging instrument with integrated cone beam CT (CBCT): the Xstrahl Small Animal Radiation Research Platform-200 (SARRP- 200). This instrument is requested by the faculty at The Wistar Institute in Philadelphia. The Wistar Institute is the nation’s oldest independent biomedical research institute, with an energized and highly collaborative faculty who perform cutting-edge research on cancer biology, immunology and vaccines. The Institute boasts a long history of research success in monoclonal antibody therapy and cancer biology (Stelara®) and vaccines (RotaTeq©), including the second COVID-19 vaccine to move into clinical testing in the United States. The instrument selected, the SARRP-200, introduces critical new capabilities for Wistar Investigators, who are currently unable to perform image-guided radiotherapy in small animals (mice), or to use whole-body radiation of mice for myelo-ablation using our current system. The latter technique is urgently needed for our ability to create and characterize humanized mice (mice with human immune systems). Our studies on humanized mice is a pioneering effort shared by several Investigators at the Institute, and for this and other projects it is expected that the SARRP-200 will be a critical synergy platform for Wistar research efforts. Because of IACUC restrictions regarding the transport of immuno- compromised mice, Wistar faculty are unable to use either of the two SARRPs located at the nearby University of Pennsylvania. However, we have taken advantage of the expertise of our nearby colleagues, and they are listed on our advisory board and program management team. Installation and immediate usage of the SARRP-200 will be facilitated by our already-trained personnel, our Internal Advisory Committee, and by our experienced Program Management team, which includes radiation oncology and medical physics personnel from the University of Pennsylvania. Our planned purchase of a SARRP-200 will replace a thirty year old cesium irradiator with a fragile motorized platform that is subject to frequent disrepair. The requested instrument will be placed within the Cell and Animal Irradiation Core, in designated space on the ground floor of the East Building at the Wistar Institute in Philadelphia PA, with direct access to a designated procedure room and the Laboratory Animal Facility. The planned purchase of the SARRP-200 is expected to offer significant new capabilities to Wistar researchers, and to energize the research of an already highly collaborative faculty.

项目概要 该申请要求资金用于独立的精密 X 射线辐照器和成像仪器 集成锥形束 CT (CBCT)：Xstrahl 小动物辐射研究平台-200 (SARRP- 200）。该仪器是由费城威斯塔研究所的教师要求提供的。 研究所是美国历史最悠久的独立生物医学研究所，拥有一支充满活力、高度重视的研究机构。 在癌症生物学、免疫学和疫苗方面进行前沿研究的合作教师。 研究所在单克隆抗体治疗和癌症生物学方面拥有悠久的研究成功历史 (Stelara®) 和疫苗 (RotaTeq©)，包括第二种进入临床测试的 COVID-19 疫苗 在美国，所选的仪器 SARRP-200 引入了重要的新功能。 Wistar 研究人员目前无法对小动物进行图像引导放射治疗 （小鼠），或使用我们当前的系统对小鼠进行全身辐射进行骨髓消融。 我们迫切需要技术来创造和表征人源化小鼠（具有人类特征的小鼠） 我们对人源化小鼠的研究是几位研究人员共同的开创性努力。 对于该项目和其他项目，预计 SARRP-200 将发挥关键的协同作用 由于 IACUC 对免疫运输的限制，Wistar 研究工作的平台。 受感染的小鼠，Wistar 教员无法使用位于附近的两个 SARRP 中的任何一个 然而，我们利用了附近同事的专业知识， 他们被列入我们的顾问委员会和项目管理团队。 我们经过培训的人员、我们的内部咨询人员将促进 SARRP-200 的使用 委员会，以及我们经验丰富的项目管理团队，其中包括放射肿瘤学和 我们计划购买 SARRP-200。 将用脆弱的电动平台取代已有 30 年历史的铯辐照器，该平台经常受到损坏 所要求的仪器将被放置在细胞和动物辐照核心内，位于 宾夕法尼亚州费城威斯塔研究所东楼底层的指定空间， 直接进入指定的手术室和实验动物设施 计划购买。 SARRP-200 预计将为 Wistar 研究人员提供重要的新功能，并为 已经高度协作的教师的研究。