Whole-Room Calorimeter

全房间热量计

• 批准号: 10431445
• 负责人: ARLENE B CHAPMAN
• 金额: $ 128.4万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-15 至 2024-09-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10431445
• 关键词: Advocate; Anorexia; Body Weight decreased; Chicago; Chronic Kidney Failure; Cities; Complex; Congestive Heart Failure; Controlled Environment; Diabetes Mellitus; Disease; Eating; Energy Metabolism; Equipment; Family; Food; Funding; Gold; Head; Health; Hospitals; Hour; Illinois; Inflammatory Bowel Diseases; Institutes; Institution; Investigation; Kidney Diseases; Life; Long COVID; Measurement; Measures; Medical; Metabolic; Metabolic syndrome; Metabolism; Michigan; Obesity; Patients; Physical activity; Research; Research Personnel; Rest; Role; Site; Sleep; Technology; Thyroid Diseases; Thyroid Function Tests; United States National Institutes of Health; Universities; Wisconsin; base; circadian; circadian biology; doubly-labeled water; experience; frailty; instrumentation; microbiome; nutrition; programs; standard measure; translational medicine

Abstract The Institute for Translational Medicine (ITM) at the University of Chicago (UChicago) proposes to purchase and install a large and flex indirect calorimeter (IC) to support leading research programs in metabolism, diabetes, obesity, disorders of thyroid function, the microbiome, inflammatory bowel disease, weight reduction, frailty, circadian biology, and kidney disorders, among others. IC is the gold standard for measuring energy expenditure (EE) providing precise and accurate measures under regulated environmental conditions, ranging from maximal physical activity to sleep (SMR). For over 15 years UChicago investigators have measured EE using metabolic carts and doubly-labelled water, which only measures resting EE or RMR, for a limited duration (maximum 4 hours), requiring an over-the-head hood placement, limiting free mobility and with less precision than IC. Despite these limitations, UChicago NIH-funded investigators have incorporated measures of EE since 2004 resulting in highly impactful scientific findings. The IC proposed in this application is the only equipment available for long term (24hrs or more) EE measurements, that can determine circadian EE (ie RMR vs. SMR) with strictly controlled environmental conditions while aspects of daily life are evaluated including eating or thermal effects of food (TEF), sleeping (SMR) and physical activity. With the establishment of the Microbiome Center in 2015 and the Duchossois Family Institute in 2017 at UChicago, world-leading programs in the microbiome in health and disease are now being established. There is strong evidence for the impact of the microbiome on EE in a variety of complex medical disorders such as obesity, anorexia, metabolic syndrome, diabetes, circadian biology, chronic kidney disease, post COVID 19 syndromes, congestive heart failure and inflammatory bowel disease. However, EE changes associated with these disorders are nuanced and limitations in precision and accuracy require better instrumentation. Use of the IC proposed in this application will help to optimize patient long-term health in a variety of medical settings. By having capacity for IC measurement of EE while collecting biofluids simultaneously in a controlled environment, the contributory roles of the microbiome, metabolism and circadian biology can be characterized. Through the ITM, a multi-institution CTSA program partnered with Rush University and affiliated with Loyola University, Northshore Hospital, Advocate Center and the Illinois Institute for Technology, city-wide utilization of the IC will be facilitated and supported. Investigators from other Chicago- based institutions including Northwestern University and University of Illinois, and regional or great lakes such as University of Wisconsin and the Nutrition Obesity Research Center (NORC) investigators from University of Michigan, will perform scientific investigations. Seminars with experienced investigators in EE from other sites will advance and disseminate scientific findings from this center and advance multiple fields forward.

抽象的 芝加哥大学（UCHICAGO）的转化医学研究所（ITM）提议购买和 安装大型和柔性的间接热量表（IC），以支持代谢，糖尿病， 肥胖，甲状腺功能的疾病，微生物组，炎症性肠病，体重减轻，脆弱， 昼夜节律生物学和肾脏疾病等。 IC是测量能量支出的黄金标准 （EE）在受规定的环境条件下提供精确，准确的措施，从最大 睡眠的体育锻炼（SMR）。 15年来，乌奇加哥研究人员已经使用代谢来测量EE 手推车和双标记的水，仅测量静止EE或RMR，持续时间有限（最多4 小时），需要额外的引擎盖放置，限制了自由移动性，而不是IC的精确度较低。尽管 这些局限性，Uchicago NIH资助的研究人员自2004年以来已采取了EE的衡量标准，导致 高度影响力的科学发现。本应用程序中提出的IC是唯一可长期使用的设备 术语（24小时或以上）EE测量，可以严格确定昼夜节律EE（即RMR与SMR） 在评估日常生活方面，包括饮食或热效应，在评估日常生活的各个方面 食物（TEF），睡眠（SMR）和体育锻炼。随着2015年微生物组中心的建立 以及2017年Duchossois家庭研究所在乌奇加哥，《卫生微生物组》的世界领先计划 现在正在建立疾病。有强有力的证据表明微生物组对EE的影响 多种复杂的医学疾病，例如肥胖，厌食症，代谢综合征，糖尿病，昼夜节律生物学， 慢性肾脏疾病，Covid 19综合征，充血性心力衰竭和炎症性肠病。 但是，与这些疾病相关的EE变化是细微的，精确和准确性的局限性 需要更好的仪器。在本应用中提出的IC的使用将有助于长期优化患者 在各种医疗环境中的健康。通过在收集生物流体时具有IC测量的能力 同时在受控环境中，微生物组，代谢和昼夜节律的作用 生物学可以被描述。通过ITM，一个多机构的CTSA计划与Rush University合作 以及洛约拉大学，北岸医院，倡导者中心和伊利诺伊州研究所 技术，全市范围的IC利用率将得到促进和支持。其他芝加哥的调查员 - 基于西北大学和伊利诺伊大学的机构以及地区或大湖泊 威斯康星大学和营养肥胖研究中心（NORC）的研究人员 密歇根州将进行科学研究。来自其他网站的EE的经验丰富的调查员研讨会 将从该中心进步并传播科学发现，并向前进。