Nicotine Withdrawal and Reward Processing: Connecting Neurobiology toReal-World Behavior

尼古丁戒断和奖励处理：将神经生物学与现实世界行为联系起来

基本信息

批准号：
10439154
负责人：
Jason Anthony Oliver
金额：
$ 15.8万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10439154
关键词：
Adult Applied Research Automobile Driving Award Basic Science Behavior Behavioral Brain Child Cigarette Smoker Clinical Trials Cues Data Development Disease Ecological momentary assessment Environment Equilibrium Evaluation Frequencies Functional Magnetic Resonance Imaging Funding Future Goals Health Image Intervention K-Series Research Career Programs Laboratories Laboratory Finding Mentored Patient-Oriented Research Career Development Award Mentors Methodology Methods Modeling Motivation Neurobiology Nicotine Nicotine Dependence Nicotine Withdrawal Participant Play Procedures Randomized Research Research Personnel Research Project Grants Restaurants Rewards Role Satiation Scientist Smoke Smoker Smoking Smoking Behavior Smoking Cessation Intervention Stimulus Tobacco smoking behavior Tobacco use Training Translational Research Validation Visit Withdrawal Work addiction brain behavior career career development cigarette smoking clinical development clinical trial analysis clinically relevant design experience innovation insight interest low nicotine content cigarette mobile computing neuroeconomics neuroimaging neuromechanism nicotine reward non-smoking novel novel strategies patient oriented pleasure programs public health relevance relating to nervous system response reward processing sex skills smoking cessation theories time use training project translational approach translational impact translational research program

项目摘要

PROJECT SUMMARY/ABSTRACT The goal of this K23 Mentored Patient-Oriented Research Career Development Award is to provide the candidate, Dr. Jason Oliver, with the training necessary to establish a career as an independent investigator conducting translational research on tobacco use and smoking cessation. Current understanding of the mechanisms responsible for driving smoking behavior is limited and existing smoking cessation treatments are modestly effective at best. The proposed training and research project center on a novel framework for understanding smoking behavior emphasizing the imbalance between rewards attainable through cigarette smoking relative to other non-smoking environmental rewards. The study will examine the effects of nicotine withdrawal on reward imbalances among 60 cigarette smokers. An innovative strategy will be used to systematically identify personally-relevant smoking and alternative rewards in order to enhance the salience of the rewards and increase the potential for findings to inform the development of clinical interventions. A translational approach will be used to assess reward responses in parallel inside the laboratory as well as outside the lab in real-time using mobile technology. In the first aim, we will examine the effects of nicotine withdrawal on neurobiological responses to images of personally-relevant smoking and non-smoking reward stimuli taken from the smoker’s natural environment using functional neuroimaging (fMRI). In the second aim, we will examine the effects of withdrawal on the frequency with which they engage in these behaviors and the magnitude of the reward response. The third aim will examine the relationship between laboratory and real- world responses. Results will enhance our understanding of the neural mechanisms of reward imbalances and the role these mechanisms play in driving smoking behavior. As part of the broader career development of the applicant, he will receive training from a team of well-established investigators with expertise related to the above topics. Dr. Adam Leventhal will provide conceptual training in the role of alternative rewards in smoking. Dr. Scott Huettel will provide conceptual training in neuroeconomics and methodological training in functional neuroimaging. Dr. Jean Beckham will provide methodological training in the assessment of real-world smoking behavior. Dr. Robert Schnoll will provide training in the design and analysis of clinical trials for smoking cessation. Dr. Joseph McClernon will guide overall professional and contribute to training in functional neuroimaging, smoking cessation clinical trials and the development of a translational research program more broadly. Ultimately, this K23 application will provide the candidate with the training and experience necessary to function as an independent research scientist conducting both basic and applied research on smoking behavior and successfully compete for R01 funding upon completion of the award.

项目概要/摘要 K23 指导的以患者为导向的研究职业发展奖的目标是提供候选人 Jason Oliver 博士，接受过独立调查员职业所需的培训开展有关烟草使用和戒烟的转化研究。导致吸烟行为的机制有限，现有的戒烟治疗方法拟议的培训和研究项目的中心是一个新颖的框架。了解吸烟行为，强调通过香烟获得的奖励之间的不平衡吸烟相对于其他非吸烟环境奖励的研究将考察尼古丁的影响。一项创新策略将用于解决 60 名吸烟者的奖励不平衡问题。系统地识别与个人相关的吸烟和替代奖励，以增强吸烟的显着性奖励并增加研究结果为临床干预措施的发展提供信息的潜力。转化方法将用于在实验室内并行评估奖励反应以及在实验室外使用移动技术进行实时检测第一个目标是，我们将检查尼古丁的影响。对与个人相关的吸烟和不吸烟奖励图像的神经生物学反应的撤回使用功能神经成像 (fMRI) 从吸烟者的自然环境中获取刺激。我们将研究戒断对他们从事这些行为的频率的影响以及第三个目标将检查实验室和现实之间的关系。结果将增强我们对奖励失衡和神经机制的理解。这些机制在推动吸烟行为方面发挥的作用。作为更广泛的职业发展的一部分。申请人将接受由具有相关专业知识的成熟研究人员团队提供的培训 Adam Leventhal 博士将提供关于替代奖励在吸烟中的作用的概念培训。 Scott Huettel 博士将提供神经经济学概念培训和功能学方法培训 Jean Beckham 博士将提供评估现实世界吸烟情况的方法学培训。 Robert Schnoll 博士将提供有关吸烟临床试验设计和分析的培训。 Joseph McClernon 博士将指导整体专业并为功能性培训做出贡献。神经影像学、戒烟临床试验和转化研究计划的开发更多总的来说，这个 K23 申请将为候选人提供必要的培训和经验。作为独立研究科学家进行吸烟的基础和应用研究行为并在完成奖项后成功竞争 R01 资金。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Commentary on Kunas et al.: Hijacked brain reward systems-how methodological advances can help to bridge gaps in the translational science pipeline.

Kunas 等人的评论：被劫持的大脑奖励系统——方法论的进步如何帮助弥合转化科学管道中的差距。

DOI：
10.1111/add.15678
发表时间：
2022
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Oliver,JasonA;Sweitzer,MaggieM
通讯作者：
Sweitzer,MaggieM

Precision medicine in addiction research: where has the time gone?

成瘾研究中的精准医学：时间都去哪儿了？

DOI：
10.1111/add.14023
发表时间：
2017
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Oliver,JasonA;McClernon,FJoseph
通讯作者：
McClernon,FJoseph

What Do Smokers Want in A Smartphone-Based Cessation Application?

DOI：
10.1093/ntr/ntx171
发表时间：
2018-12-01
期刊：
NICOTINE & TOBACCO RESEARCH
影响因子：
4.7
作者：
Oliver, Jason A.;Hallyburton, Matthew B.;McClernon, F. Joseph
通讯作者：
McClernon, F. Joseph

Using Neuroscience to Inform Tobacco Control Policy.

DOI：
10.1093/ntr/nty057
发表时间：
2019-05-21
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
0
作者：
Maynard OM;McClernon FJ;Oliver JA;Munafò MR
通讯作者：
Munafò MR

Prediction of Smoking Risk From Repeated Sampling of Environmental Images: Model Validation.