Nicotine Withdrawal and Reward Processing: Connecting Neurobiology toReal-World Behavior

尼古丁戒断和奖励处理：将神经生物学与现实世界行为联系起来

基本信息

批准号：
10439154
负责人：
Jason Anthony Oliver
金额：
$ 15.8万
依托单位：
UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10439154
关键词：
Adult Applied Research Automobile Driving Award Basic Science Behavior Behavioral Brain Child Cigarette Smoker Clinical Trials Cues Data Development Disease Ecological momentary assessment Environment Equilibrium Evaluation Frequencies Functional Magnetic Resonance Imaging Funding Future Goals Health Image Intervention K-Series Research Career Programs Laboratories Laboratory Finding Mentored Patient-Oriented Research Career Development Award Mentors Methodology Methods Modeling Motivation Neurobiology Nicotine Nicotine Dependence Nicotine Withdrawal Participant Play Procedures Randomized Research Research Personnel Research Project Grants Restaurants Rewards Role Satiation Scientist Smoke Smoker Smoking Smoking Behavior Smoking Cessation Intervention Stimulus Tobacco smoking behavior Tobacco use Training Translational Research Validation Visit Withdrawal Work addiction brain behavior career career development cigarette smoking clinical development clinical trial analysis clinically relevant design experience innovation insight interest low nicotine content cigarette mobile computing neuroeconomics neuroimaging neuromechanism nicotine reward non-smoking novel novel strategies patient oriented pleasure programs public health relevance relating to nervous system response reward processing sex skills smoking cessation theories time use training project translational approach translational impact translational research program

项目摘要

PROJECT SUMMARY/ABSTRACT The goal of this K23 Mentored Patient-Oriented Research Career Development Award is to provide the candidate, Dr. Jason Oliver, with the training necessary to establish a career as an independent investigator conducting translational research on tobacco use and smoking cessation. Current understanding of the mechanisms responsible for driving smoking behavior is limited and existing smoking cessation treatments are modestly effective at best. The proposed training and research project center on a novel framework for understanding smoking behavior emphasizing the imbalance between rewards attainable through cigarette smoking relative to other non-smoking environmental rewards. The study will examine the effects of nicotine withdrawal on reward imbalances among 60 cigarette smokers. An innovative strategy will be used to systematically identify personally-relevant smoking and alternative rewards in order to enhance the salience of the rewards and increase the potential for findings to inform the development of clinical interventions. A translational approach will be used to assess reward responses in parallel inside the laboratory as well as outside the lab in real-time using mobile technology. In the first aim, we will examine the effects of nicotine withdrawal on neurobiological responses to images of personally-relevant smoking and non-smoking reward stimuli taken from the smoker’s natural environment using functional neuroimaging (fMRI). In the second aim, we will examine the effects of withdrawal on the frequency with which they engage in these behaviors and the magnitude of the reward response. The third aim will examine the relationship between laboratory and real- world responses. Results will enhance our understanding of the neural mechanisms of reward imbalances and the role these mechanisms play in driving smoking behavior. As part of the broader career development of the applicant, he will receive training from a team of well-established investigators with expertise related to the above topics. Dr. Adam Leventhal will provide conceptual training in the role of alternative rewards in smoking. Dr. Scott Huettel will provide conceptual training in neuroeconomics and methodological training in functional neuroimaging. Dr. Jean Beckham will provide methodological training in the assessment of real-world smoking behavior. Dr. Robert Schnoll will provide training in the design and analysis of clinical trials for smoking cessation. Dr. Joseph McClernon will guide overall professional and contribute to training in functional neuroimaging, smoking cessation clinical trials and the development of a translational research program more broadly. Ultimately, this K23 application will provide the candidate with the training and experience necessary to function as an independent research scientist conducting both basic and applied research on smoking behavior and successfully compete for R01 funding upon completion of the award.

项目摘要/摘要该K23指导的以患者为导向的研究职业发展奖的目标是提供候选人杰森·奥利弗（Jason Oliver）博士，他们的培训是建立独立调查员职业的必要培训进行烟草使用和戒烟的转化研究。当前对负责驱动吸烟行为的机制有限，现有的戒烟治疗是充其量是适度的。拟议的培训和研究项目中心关于新颖的框架了解吸烟行为强调通过香烟获得奖励之间的不平衡相对于其他非吸烟环境奖励吸烟。该研究将检查尼古丁的影响在60名吸烟者中提取奖励失衡。创新策略将用于系统地识别与个人相关的吸烟和替代奖励，以增强奖励并增加了调查结果的潜力，以告知临床干预的发展。一个翻译方法将用于评估实验室内部并行的奖励反应以及实时使用移动技术实时外面。在第一个目标中，我们将研究尼古丁的影响撤回对个人相关吸烟和非吸烟奖励的图像的神经生物学反应刺激使用功能性神经影像学（fMRI）从吸烟者的自然环境中摄取。在第二个目标中我们将研究撤回对它们参与这些行为的频率的影响以及奖励响应的大小。第三个目标将研究实验室与现实之间的关系世界回应。结果将增强我们对奖励失衡的神经机制的理解和这些机制在推动吸烟行为中起着作用。作为广泛职业发展的一部分申请人，他将接受由成熟的调查员团队的培训，该研究人员的专业知识与以上主题。亚当·莱文塔尔（Adam Leventhal）博士将提供概念培训，以替代奖励在吸烟中的作用。 Scott Huettel博士将在功能方面提供神经经济学和方法学培训的概念培训神经影像学。让·贝克汉姆（Jean Beckham）博士将在评估现实世界吸烟的评估中提供方法论培训行为。罗伯特·施诺尔（Robert Schnoll）博士将在吸烟的临床试验设计和分析方面提供培训停止。约瑟夫·麦克伦农博士将指导整体专业人士，并为功能培训做出贡献神经影像学，戒烟临床试验和转化研究计划的发展更多广泛。最终，该K23申请将为候选人提供必要的培训和经验充当独立的研究科学家，同时进行吸烟的基础研究和应用研究颁奖典礼完成后，行为并成功争夺R01的资金。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Commentary on Kunas et al.: Hijacked brain reward systems-how methodological advances can help to bridge gaps in the translational science pipeline.

Kunas 等人的评论：被劫持的大脑奖励系统——方法论的进步如何帮助弥合转化科学管道中的差距。

DOI：
10.1111/add.15678
发表时间：
2022
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Oliver,JasonA;Sweitzer,MaggieM
通讯作者：
Sweitzer,MaggieM

What Do Smokers Want in A Smartphone-Based Cessation Application?

DOI：
10.1093/ntr/ntx171
发表时间：
2018-12-01
期刊：
NICOTINE & TOBACCO RESEARCH
影响因子：
4.7
作者：
Oliver, Jason A.;Hallyburton, Matthew B.;McClernon, F. Joseph
通讯作者：
McClernon, F. Joseph

Precision medicine in addiction research: where has the time gone?

成瘾研究中的精准医学：时间都去哪儿了？

DOI：
10.1111/add.14023
发表时间：
2017
期刊：
Addiction (Abingdon, England)
影响因子：
0
作者：
Oliver,JasonA;McClernon,FJoseph
通讯作者：
McClernon,FJoseph

Using Neuroscience to Inform Tobacco Control Policy.

DOI：
10.1093/ntr/nty057
发表时间：
2019-05-21
期刊：
Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
影响因子：
0
作者：
Maynard OM;McClernon FJ;Oliver JA;Munafò MR
通讯作者：
Munafò MR

Prediction of Smoking Risk From Repeated Sampling of Environmental Images: Model Validation.