Energy Balance Core

能量平衡核心

• 批准号: 10426297
• 负责人: GREGORY J MORTON
• 金额: $ 21.37万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2025-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10426297
• 关键词: Address; Analysis of Covariance; Animal Model; Animals; Area; Behavioral; Biological Assay; Biological Process; Biopsy Specimen; Body Temperature; Brown Fat; Cardiovascular Diseases; Communities; Computer software; Consult; Data; Data Analyses; Development; Diabetes Mellitus; Educational process of instructing; Educational workshop; Energy Intake; Energy Metabolism; Ensure; Equipment; Funding; Gold; High Prevalence; Homeostasis; Human Resources; Humidity; Hypertension; Indirect Calorimetry; Intervention; Knowledge; Leadership; Linear Regressions; Measurement; Measures; Metabolic; Methods; Modeling; Monitor; Mus; National Institute of Diabetes and Digestive and Kidney Diseases; Nutritional Science; Obesity; Pathogenesis; Pattern; Performance; Pharmacology; Phenotype; Physiologic Thermoregulation; Physiological; Physiology; Play; Procedures; Process; Productivity; Provider; Public Health; Quality Control; Regulation; Research; Research Design; Research Personnel; Resources; Rodent; Rodent Model; Role; Running; Scientific Advances and Accomplishments; Services; Tail; Techniques; Temperature; Testing; Thermogenesis; Time; Tissues; Training; Training Activity; Universities; Washington; base; comorbidity; cost effective; design; energy balance; evidence based guidelines; experience; genetic manipulation; improved; innovation; instrumentation; interest; metabolic abnormality assessment; metabolic phenotype; next generation; novel therapeutic intervention; nutrition; organizational structure; programs; respiratory; service providers; therapeutically effective; tool; training opportunity

The Energy Balance Core is directed by Greg Morton, with Joshua Thaler serving as Associate Core Director. The primary function of this Core is to provide Affiliate Investigators (AIs) with state-of-the-art resources for comprehensive metabolic phenotyping of rodents. The Specific Aims for the Energy Balance Core are: Specific Aim 1: To provide AIs with a state-of-the-art resource for comprehensive energy balance and metabolic phenotyping of rodent models relevant to nutrition and obesity. The EB Core provides comprehensive quantitative assessment of energy balance parameters including indirect calorimetry with energy expenditure normalization by multiple linear regression, body and tissue composition on living and biopsied specimens, ambulatory activity, wheel running activity and energy intake with meal pattern analysis. We also offer video monitoring services and extensive thermoregulatory services including continuous core body temperature monitoring, calculation of thermal conductance, thermal gradient tests, and measures of brown adipose tissue and tail-temperature that can be performed at any ambient temperature using temperature- controlled chambers. As the EB Core is the sole provider of these services in the Seattle area, the UW NORC plays a critical role in the productivity and scientific advances of the nutrition and obesity research community. Specific Aim 2: To create an organizational structure that ensures that services are provided to AIs in a timely, efficient and cost-effective manner and that quality control for all services is routinely assessed. We optimize the scope of services offered and ensure that they fit seamlessly and without overlap with services offered via other UW programs and centers. To ensure services are provided to AIs in a timely and efficiency manner, the EB Core has implemented a streamlined process for animal transfers and handling; have highly skilled and trained personnel with extensive experience managing technically demanding equipment to ensure consistency and quality control; and strong leadership with expertise in the design, performance, analysis and interpretation of rodent metabolic phenotypes related to nutrition and obesity. Specific Aim 3: To develop new services that keep pace with relevant technological advances and address the evolving needs of our user base. Over the past 5 years, we have incorporated a number of innovative techniques into our expanded menu of offered services. We obtained a thermocline and temperature-controlled metabolic chambers for adaptive thermogenesis studies and introduced quantitative approaches to measure thermal conductance. In addition, we devote time and resources to teaching and training activities both to our NORC AIs and the broader scientific community, including normalization of energy expenditure data and the development of a seminar and workshop related to the regulation of energy homeostasis and use of indirect calorimetry equipment.

能量平衡核心由格雷格·莫顿（Greg Morton）指导，约书亚·塔勒（Joshua Thaler）担任副总监。 该核心的主要功能是为会员调查员（AIS）提供最先进的资源 啮齿动物的综合代谢表型。能量平衡核心的具体目的是： 特定目的1：为AI提供最先进的资源，以实现全面的能源平衡 以及与营养和肥胖有关的啮齿动物模型的代谢表型。 EB核心提供了包括间接参数的能量平衡参数的全面定量评估 通过多种线性回归，身体和组织组成的能量消耗量表的量热法归一化 生存和活检标本，门诊活动，轮子跑步活动以及用餐模式的能量摄入 分析。我们还提供视频监控服务和广泛的热调节服务，包括连续 核心体温监测，导热电导的计算，热梯度测试和测量 棕色脂肪组织和尾部温度，可以在任何环境温度下进行温度 受控室。由于EB核心是西雅图地区这些服务的唯一提供商，UW NORC 在营养和肥胖研究社区的生产力和科学进步中起着至关重要的作用。 特定目的2：创建一个组织结构，以确保为AIS提供服务 及时，高效且具有成本效益的方式，所有服务的质量控制是常规的 评估。 我们优化了提供的服务范围，并确保它们无缝地适合，并且不与服务重叠 通过其他UW计划和中心提供。确保为AIS提供及时，效率的服务 方式，EB核心已经实施了一种简化的动物转移和处理过程。有很高的 熟练和训练有素的人员具有丰富的经验，可以管理技术要求的设备以确保 一致性和质量控制；在设计，性能，分析和 与营养和肥胖有关的啮齿动物代谢表型的解释。 特定目的3：开发与相关技术进步的新服务和 满足我们用户群的不断发展的需求。 在过去的5年中，我们将许多创新技术纳入了我们的扩展菜单 提供服务。我们获得了一个热跃层和温度控制的代谢室，以进行自适应 热生成研究并引入了测量热电导的定量方法。此外， 我们将时间和资源投入到我们的NORC AI和更广泛的科学方面的教学和培训活动上 社区，包括能源支出数据的归一化以及研讨会和研讨会的开发 与能量稳态的调节和间接量热法设备的使用有关。