Influence of the College Football Athletes' Cumulative Head Impact Exposure (HIE) on the mTBI incidence and post-mTBI health outcomes

大学橄榄球运动员累积头部撞击暴露 (HIE) 对 mTBI 发生率和 mTBI 后健康结果的影响

• 批准号: 10420062
• 负责人: Jaroslaw Harezlak
• 金额: $ 37.08万
• 依托单位: TRUSTEES OF INDIANA UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-03-01 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10420062
• 关键词: Acceleration; Accident and Emergency department; Accounting; Acute; Address; Athletic; Biomechanics; Brain; Brain Concussion; Characteristics; Clinical; Computers; Data; Data Set; Education; Enrollment; Equilibrium; Excision; Exposure to; Frequencies; Goals; Head; Health; Human; Incidence; Individual; Injury; Intervention; Literature; Manufactured football; Measurement; Measures; Medical; Medical Staff; Modeling; Modernization; Outcome; Personality Traits; Play; Policies; Positioning Attribute; Protective Devices; Public Health; Recording of previous events; Recovery; Reporting; Research; Risk; Risk Factors; Rotation; Safety; Seasons; Series; Severities; Sports; Statistical Methods; Statistical Models; Symptoms; System; Techniques; Testing; Time; Training; United States; base; cognitive function; college; contact sports; demographics; head impact; high school; improved; injury prevention; innovation; machine learning method; mild traumatic brain injury; prediction algorithm; prototype; tool

Project Abstract Sport-related concussion (SRC) is a significant public health problem resulting in over 200,000 annual trips to the Emergency Department (ED) in the United States with as many as 3.8 million SRCs occurring annually. From a biomechanical standpoint, the concussion mechanism includes head impact resulting in high magnitude head rotational accelerations. Human studies measuring the accelerations associated with concussive head impacts developed injury risk curves that can be extremely useful from the clinical and safety perspectives. However, recent literature has shown that acceleration magnitudes associated with concussive impacts are extremely variable and not necessarily distinct from the routinely sustained head impact magnitudes. Mounting evidence from human studies has demonstrated that repetitive head impact exposure (HIE) may contribute to decreased SRC tolerance in contact sport athletes. Studies focused on quantifying the relationship between the HIE and incident concussion have been underpowered, as there were limited number of concussions occurring during the observation period. We will utilize the data from the NCAA-DoD Concussion Assessment, Research and Education Consortium (CARE) Head Impact Measurement Core, the largest and most comprehensive study of SRC and repetitive HIE to date, and data from Project Head-to-Head 2 (PHTH2), a large-scale study of SRC and HIE in both collegiate and high school athletes to: (1) determine the association of HIE to SRC occurrence and post-SRC recovery based on the frequency, number, recency, and severity of head impacts sustained in football activities; and (2) build a dynamic predictive algorithm of the SRC risk based on the HIE time series data obtained from the HIT System and other factors, including demographics, concussion history, impact characteristics, and network measures.

项目摘要 与运动有关的脑震荡（SRC）是一个重大的公共卫生问题，每年超过200,000次旅行 美国的急诊科（ED）每年发生多达380万SRC。从 生物力学的角度，脑震荡机制包括头部撞击，导致头部高 旋转加速度。人类研究测量与脑震荡相关的加速度影响 从临床和安全角度来看，开发的伤害风险曲线可能非常有用。然而， 最近的文献表明，与脑震荡相关的加速度幅度极为 可变，不一定与常规持续的头部冲击幅度不同。越来越多的证据 人类研究表明，重复的头部撞击暴露（HIE）可能有助于下降 与体育运动员的SRC耐受性。 旨在量化HIE与入射脑震荡之间关系的研究已经 能力不足，因为观察期间发生脑震荡数量有限。我们将 利用NCAA-DOD脑震荡评估，研究和教育联盟（CARE）中的数据 头部冲击测量核心，迄今为止最大，最全面的SRC和重复性研究， 以及项目面对面2（PHTH2）的数据，SRC和HIE的大规模研究 学校运动员：（1）根据基于SRC发生的HIE与SRC的关联和基于SRC后的恢复 足球活动中受到的头部影响的频率，数量，新近和严重程度； （2）建造一个 SRC风险的动态预测算法基于从命中系统获得的HIE时间序列数据 以及其他因素，包括人口统计学，脑震荡历史，影响特征和网络度量。