Clinical Research Resources and Facilities

临床研究资源和设施

基本信息

批准号：
10417259
负责人：
MELVIN BONILLA-FELIX
金额：
$ 23.97万
依托单位：
UNIVERSITY OF PUERTO RICO MED SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-02 至 2025-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10417259
关键词：
Address Adherence Cardiometabolic Disease Caribbean Hispanic Clinical Practice Guideline Clinical Research Communicable Diseases Communities Core Facility Data Development Disasters Disease Emerging Communicable Diseases Ensure Goals Good Clinical Practice Health Healthcare Hispanic Hispanic Populations Hispanic-serving Institution Infrastructure Interdisciplinary Study Knowledge Language Malignant Neoplasms Methodology Minority Participant Population Positioning Attribute Process Puerto Rico Regulation Research Research Personnel Resources Scientist Structure Subgroup Translating Translational Research burden of illness cost effective cultural competence effective therapy ethnic minority hispanic community human subject improved medically underserved medically underserved population programs quality assurance racial minority recruit research facility research study retention rate treatment guidelines

项目摘要

Abstract/Summary Improving health care for the medically underserved, including our Hispanic population, afflicted by prevalent diseases, such as cancer, cardio-metabolic and infectious diseases, remains a major challenge. Limited representation of racial and ethnic minorities in clinical and translational research is an important challenge that limits the generalizability of results and contributes to the disproportionate disease burden in these groups. There is a need to increase the representation of Hispanic research participants and researchers in clinical and translational research to improve the generalizability and applicability of research findings and identify ethnic-specific differences that could dictate changes in treatment guidelines and facilitate research in this population. The Clinical Research Resources and Facilities Core of the Alliance is well positioned to address the gap in the participation of Hispanic subjects in clinical research and increase the number of Hispanic scientists participating in clinical and translational research, given their access to resident populations of both underrepresented Hispanic participants and Hispanic scientists. The goal of the Clinical Research Resources and Facilities Core (CRRF) is to facilitate and enhance safe and cost-effective clinical and translational research, with an emphasis in health problems of Hispanics and medically underserved populations. The specific objective is to provide a coordinated structure across a predominantly Hispanic IDeA jurisdiction to support collaborative multi-and interdisciplinary clinical and translational research and increase the participation and retention of Hispanic research participants. The rationale that underlies this proposal is that establishing and integrating resources across multiple Hispanic-serving Institutions and groups, staffed by culturally consonant investigators and staff, in a Hispanic US jurisdiction, will overcome many of the barriers that impact participation of Hispanics in research, which in turn will translate into more studies and more data about diseases prevalent in Hispanics. Our objective will be accomplished through three specific aims: 1) Establish an integrated network of clinical and translational research resources and facilities to enhance cost-effective, multidisciplinary and inter- disciplinary research, in health conditions prevalent among Hispanic populations; 2) Facilitate and increase the recruitment and retention of research participants from underserved Hispanic communities; 3) Ensure that clinical and translational research with human subjects is safe and of the highest quality. When these aims are completed we will impact the representation of Caribbean Hispanics as study participants and as investigators.

摘要/摘要改善医疗服务不足的医疗保健，包括我们的西班牙裔人口普遍的疾病，例如癌症，心替代疾病和传染病，仍然是一个主要挑战。种族和少数民族在临床和转化研究中的有限代表是重要的挑战限制了结果的普遍性，并导致这些疾病负担不成比例组。有必要增加西班牙裔研究参与者和研究人员的代表临床和转化研究，以提高研究发现的普遍性和适用性确定特定民族的差异，可以决定治疗指南的变化并促进研究这个人口。联盟的临床研究资源和设施核心良好地解决了西班牙裔科目参与临床研究的差距并增加了西班牙裔的数量参与临床和转化研究的科学家，鉴于他们访问了这两者的居民代表性不足的西班牙裔参与者和西班牙裔科学家。临床研究资源的目标和设施核心（CRRF）将促进和增强安全且具有成本效益的临床和翻译研究重点是西班牙裔人的健康问题和医疗服务不足的人群。具体目的是在主要的西班牙裔思想管辖区提供协调的结构以支持协作多数和跨学科的临床和翻译研究，并增加参与和保留西班牙裔研究参与者。该提议基于的基本原理是建立和在多个西班牙裔服务机构和团体中整合资源，由文化辅音组成在西班牙裔美国管辖区中的调查人员和员工将克服影响参与的许多障碍研究中的西班牙裔人，这反过来将转化为更多的研究和更多有关疾病的数据在西班牙裔。我们的目标将通过三个具体目标来完成：1）建立一个集成网络临床和转化研究资源和设施，以增强成本效益，多学科和间纪律研究，在西班牙裔人口中普遍存在的健康状况； 2）促进并增加来自服务不足的西班牙裔社区的研究参与者的招募和保留； 3）确保这一点与人类受试者的临床和翻译研究是安全的，并且具有最高的质量。当这些目标是完成后，我们将影响加勒比西班牙裔人作为研究参与者和研究人员的代表。