Archiving and harmonizing data on prevention and treatment of child traumatic stress

归档和协调有关儿童创伤应激预防和治疗的数据

• 批准号: 10415908
• 负责人: Nancy Kassam-Adams
• 金额: $ 8.8万
• 依托单位: CHILDREN'S HOSP OF PHILADELPHIA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-03 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10415908
• 关键词: Acute; Address; Adolescent; Adult; Algorithms; Archives; Child; Child Health; Child Traumatic Stress; Code; Collaborations; Common Data Element; Communities; Data; Data Aggregation; Data Element; Data Set; Deposition; Effectiveness; Elements; Ensure; Exhibits; Exposure to; FAIR principles; Funding; Goals; Impaired health; Individual; Injury; Institutes; Intervention; Intervention Studies; Intervention Trial; Knowledge; Label; Measures; Mediator of activation protein; Medical; Meta-Analysis; Metadata; Mission; Movement; Names; National Institute of Child Health and Human Development; Nature; Outcome; Participant; Peer Review; Personal Satisfaction; Persons; Post-Traumatic Stress Disorders; Prevention; Preventive treatment; Process; Prospective Studies; Publications; Research; Research Personnel; Resources; Sample Size; Sampling; Scheme; Science; Scientific Societies; Services; Sister; Solid; Standardization; Symptoms; Trauma; Trauma recovery; Treatment Effectiveness; Underrepresented Populations; Variant; Violence; Work; archive data; archived data; data archive; data dictionary; data harmonization; data integration; data preservation; data sharing; demographic disparity; effective intervention; experience; improved; individual patient; intervention effect; maltreatment; novel; post-traumatic stress; preservation; prevent; psychological outcomes; repository; secondary analysis; syntax; tool; trauma exposure; traumatic stress; traumatized children; treatment disparity; web site

The Child Trauma Prevention and Treatment (CTPT) Data Archive will address critical barriers to using existing data to improve interventions for children impacted by traumatic experiences. Exposure to trauma is unfortunately common for children and adolescents. Each year, tens of millions around the world experience trauma; a significant proportion develop traumatic stress or related sequelae that impact child health and functioning. Recent meta-analyses have found evidence for effectiveness of some preventative and treatment interventions with traumatized children, but many questions crucial to improving these interventions (eg, moderators and mediators of effectiveness) cannot be addressed with aggregate data. Single studies have small Ns that limit statistical power and the ability to examine potential demographic disparities in treatment effectiveness. Integrative cross-study analyses using individual patient data are crucial, but hindered by enormous practical barriers (access to data, effort required for dataset integration / harmonization). The CTPT Data Archive will address these critical barriers by gathering data from intervention studies around the world with children exposed to traumas such as injury, violence, or maltreatment; applying coding and metadata to facilitate cross-study harmonization; and making data and related tools and resources accessible to researchers. Developed in conjunction with the Global Collaboration on Traumatic Stress, the project advances `FAIR data principles' – making research data more Findable, Accessible, Interoperable, and Re-usable. We leverage the solid framework provided by the Prospective studies of Acute Child Trauma and Recovery (PACT/R) archive of non-intervention studies. Our overarching objective is to build an expandable research resource for the field that will enhance the utility and value of child trauma studies - and ultimately improve child trauma interventions - by facilitating integrative cross-study analyses. The project has the following specific aims: Aim 1: Initiate CTPT Archive with data from ≥ 25 intervention studies, representing >~2000 participants; Aim 2: Apply coding and metadata for individual- and study-level data elements to facilitate harmonization Aim 3: Ensure data preservation / accessibility and promote data use We will create tools and resources (including relevant syntax and algorithms) for researchers contributing or using CTPT data and disseminate these via the childtraumadata.org website, and will deposit standardized / harmonized datasets with an established repository to ensure long-term preservation and accessibility. This project advances NICHD's goal of archiving and documenting existing datasets within its scientific mission, enabling secondary analyses by the scientific community. The CTPT archive will be an ongoing research resource, taking in data and enabling novel analyses of how and for whom child trauma interventions work, so that we can effectively address the impact of trauma on child health and well-being.

儿童创伤预防和治疗（CTPT）数据存档将解决使用的关键障碍 现有数据以改善受创伤经历影响的儿童的干预措施。暴露于创伤是 不幸的是，儿童和青少年常见。每年，世界各地数千万的体验 创伤;很大的比例会产生创伤性压力或相关后遗症，影响儿童健康和 功能。最近的荟萃分析发现了一些预防和治疗有效性的证据 对受创伤儿童的干预措施，但许多问题对于改善这些干预措施至关重要（例如， 主持人和有效性的调解人无法通过汇总数据来解决。单个研究有 小型NS限制统计能力和检查治疗中潜在人口统计分布的能力 效力。使用单个患者数据进行的综合跨研究分析至关重要，但受到阻碍 巨大的实用障碍（获取数据，数据集集成 /协调所需的工作）。 CTPT数据存档将通过从干预研究中收集数据来解决这些关键障碍 在世界范围内，儿童遭受了伤害，暴力或虐待等创伤；应用编码 和元数据促进跨研究的协调；并制作数据以及相关的工具和资源 研究人员可以访问。与全球创伤压力合作一起开发 项目推进“公平数据原则” - 使研究数据更可发现，可访问，可互操作，并且 可重复使用的。我们利用急性儿童创伤前瞻性研究提供的坚实框架和 恢复（PACT/R）非干预研究的档案。 我们的总体目标是为该领域建立可扩展的研究资源，以增强 儿童创伤研究的效用和价值 - 并最终改善儿童创伤干预措施 - 通过促进 综合跨研究分析。该项目具有以下特定目标： AIM 1：启动CTPT存档，并使用≥25项干预研究的数据，代表> 〜2000参与者； 目标2：将编码和元数据应用于个体和研究级别的数据元素以促进协调 目标3：确保数据准备 /可访问性并促进数据使用 我们将为研究人员创建工具和资源（包括相关的语法和算法），以贡献或 使用CTPT数据并通过ChildTraumadata.org网站进行传播，并将存入标准化 / 将数据集与已建立的存储库协调，以确保长期准备和可访问性。 该项目促进了NICHD在其科学中归档和记录现有数据集的目标 任务，实现科学界的次要分析。 CTPT档案将是一个持续的 研究资源，获取数据并实现新的分析，分析如何以及为哪些儿童创伤干预 工作，以便我们可以有效解决创伤对儿童健康和福祉的影响。