Gynecologic Cancers Research Program

妇科癌症研究计划

• 批准号: 10413078
• 负责人: DORIS Mangiaracina BENBROOK
• 金额: $ 5.46万
• 依托单位: UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-05-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413078
• 关键词: Address; Award; Biological Specimen Banks; Cancer Center; Cancer Center Support Grant; Cancer Control; Cancer Patient; Cancer Research Project; Catchment Area; Clinical; Clinical Oncology; Clinical Trials; Collaborations; Development; Direct Costs; Doctor of Philosophy; Enrollment; Equilibrium; Funding; Goals; Grant; Gynecologic Oncology; Health Services Accessibility; Industry; Institution; Leadership; Malignant Female Reproductive System Neoplasm; Malignant Neoplasms; Molecular; Oklahoma; Outcome; Patient-Focused Outcomes; Peer Review; Phase; Publications; Publishing; Randomized; Randomized Clinical Trials; Reporting; Research; Resistance; Woman; base; cancer prevention; cancer therapy; carcinogenesis; college; design; improved; inter-institutional; investigator-initiated trial; member; multidisciplinary; novel; pre-clinical; programs; randomized trial; standard of care; translational cancer research; treatment response; treatment trial

GYNECOLOGIC CANCERS PROGRAM – ABSTRACT The goal of the Gynecologic Cancers (GC) program at the Stephenson Cancer Center (SCC) is to raise the standard of care and improve clinical outcomes for all women with gynecologic malignancies, with an emphasis on addressing problems relevant to Oklahoma, the SCC catchment area. Program members accomplish this goal by conducting transdisciplinary, team-based research that advances discovery of molecular mechanisms into early- and late-phase randomized trials. The Specific Aims for the GC program are: (1) to discover and interrogate molecular mechanisms central to carcinogenesis; (2) to investigate mechanisms underlying cancer therapy response and resistance; and (3) to design and conduct early- and late-phase randomized clinical trials that advance novel discoveries and improve patient outcomes in the catchment area and nation. Highlights of the GC program include: 1) highly interactive basic discovery and clinical members focused on gynecologic cancers; 2) Specific Aims that organize these program members into focused translational teams, leading to multi-PI grants and an exceptional rate of intra-programmatic publications; 3) a gynecologic oncology clinical program that impacts the catchment area by providing multidisciplinary care and access to clinical trials (58% enrollment rate) for half the new GC cases in Oklahoma; 4) a large annotated biospecimen bank that supports GC discovery research; 5) active development of GC-focused investigator-initiated trials and high accrual of GC patients to early-phase novel treatment trials; and 6) national leadership in the design and conduct of practice-changing NCTN- and Industry-sponsored randomized GC trials. The GC program has 18 members, representing seven departments, four colleges and two institutions, which illustrates the transdisciplinary expertise among program members. The translational focus of the program is reflected in the balance of MD (9) and PhD (9) members. As of December 31, 2016, program members were awarded $3,865,290 in annual NCI and other peer-reviewed cancer-related support (direct cost). NCI funding ($3,181,558) accounts for 82.3% of the peer-reviewed funding, highlighting the program's cancer focus. Total annual GC program funding is $8,700,601 (direct cost). For the five-year reporting period (2012-2016), GC program members published 262 peer-reviewed articles, of which 34.4% included intra-programmatic, 11.8% included inter-programmatic, and 73.3% included inter-institutional collaborators. For 2016, inter-programmatic publications were 21.1%, highlighting the increasing number of collaborations underway with the Preclinical Translational Cancer Research (PTCR) and Cancer Prevention and Control (CPC) programs.

妇科癌症计划 - 摘要 斯蒂芬森癌症中心（SCC）的妇科癌症（GC）计划的目标是提高 护理标准并改善所有患有妇科恶性肿瘤的女性的临床结果， 强调解决与SCC集水区俄克拉荷马州有关的问题。计划成员 通过进行跨学科的，基于团队的研究来实现这一目标 分子机制作为早期和晚期随机试验。 GC计划的具体目标 为：（1）发现和审问癌变中心的分子机制； （2）调查 癌症治疗反应和抗药性的机制； （3）设计和进行早期和进行 后期的随机临床试验，可提高新发现并改善患者的结局 集水区和国家。 GC计划的亮点包括：1）高度互动的基本发现和临床成员的重点 妇科癌； 2）将这些计划成员组织成专注的翻译团队的具体目标， 导致多PI赠款和出色的杂志内出版物的出色率； 3）妇科 通过提供多学科护理和访问来影响集水区域的肿瘤学临床计划 俄克拉荷马州新的GC病例一半的临床试验（58％的入学率）； 4）一个大带注释的生物镜 支持GC发现研究的银行； 5）积极开发以GC为重点的研究者发起的试验 GC患者对早期新型治疗试验的高精度； 6）设计中的国家领导 以及改变练习的NCTN和行业赞助的随机GC试验。 GC计划有18名成员，代表七个部门，四所大学和两个机构，这是 说明了计划成员之间的跨学科专业知识。该程序的翻译重点是 反映在MD（9）和PhD（9）成员的余额中。截至2016年12月31日，计划成员是 年度NCI和其他与癌症相关的支持（直接成本）的年度NCI授予3,865,290美元。 NCI资金 （$ 3,181,558）占同行评审资金的82.3％，强调了该计划的癌症重点。全部的 年度GC计划资金为8,700,601美元（直接费用）。在五年报告期（2012-2016）中，GC 计划成员发表了262篇经过同行评审的文章，其中34.4％的文章包括概括性内部图表，11.8％ 包括程序间合作，包括73.3％的机构间合作者。 2016年，截面间 出版物为21.1％，强调了与临床前的合作数量的增加 转化癌症研究（PTCR）和癌症预防与控制（CPC）计划。