In vivo insights of small vessel changes with age using USPIO-enhanced MRI

使用 USPIO 增强 MRI 观察小血管随年龄变化的体内变化

• 批准号: 10413130
• 负责人: Yulin Ge
• 金额: $ 67.8万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-15 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413130
• 关键词: 3-Dimensional; Adult; Affect; Age; Aging; Anatomy; Animals; Architecture; Area; Arteries; Arteriogram; Atlases; Autopsy; Basal Ganglia; Blood; Blood Circulation; Blood Vessels; Blood capillaries; Brain; Brain imaging; Caliber; Cerebrum; Clinical; Contrast Media; Data; Dementia; Detection; Diagnostic; Disease; Dose; Echo-Planar Imaging; Erythrocytes; Event; Extravasation; Female; Gender; Glucose; Goals; Health; Human; Image; Imaging Device; Impaired cognition; Iron; Life Cycle Stages; Longevity; Magnetic Resonance Imaging; Maps; Measures; Medical; Metabolic; Methods; Morphology; Neurodegenerative Disorders; Oxygen; Pathologic; Pathology; Physics; Physiological Processes; Play; Predisposition; Protocols documentation; Resolution; Risk Factors; Scanning; Site; Source; Speed; Stenosis; System; Techniques; Time; Tissues; Veins; Venous; Venous system; Visual; age related; aged; aging brain; arteriole; base; cerebral artery; cohort; density; experimental study; ferumoxtran; ferumoxytol; follow-up; frontal lobe; healthy volunteer; human subject; image processing; image reconstruction; improved; in vivo; innovative technologies; insight; interest; macrovascular disease; male; nervous system disorder; neuropathology; neurovascular; normal aging; novel; simulation; ultra high resolution; venule; volunteer; white matter

Project Summary / Abstract: The microvascular arterial system plays a key role in delivering oxygen and glucose to fulfill the high metabolic demand of the brain. Recently, microvascular abnormalities have been increasingly identified as the source or basis of many neurologic disorders including age-related dementia. Today, the mechanisms of both structural and functional changes due to aging are still largely unclear, and there is an urgent need for in vivo characterization as to how small vessel ages over the life course in both male and female adults. Although MRI is able to image the structural aspects of the brain with a resolution of 1mm today, it has not yet been used to study microvascular details in humans in vivo at the in-plane resolution of 100μm or less. We have developed a means by which to modify the susceptibility of the arteries using an ultra-small-superparamagnetic-iron-oxide (USPIO) to make it possible to image both small arteries and veins with susceptibility weighted imaging (SWI) and quantitative susceptibility mapping (QSM) to see micro vessels less than 100μm. Our interest in this proposal is to bring together experts in a variety of medical and scientific areas such as MR physics, image processing and reconstruction to develop a new technique which we refer to ultra-high resolution USPIO-enhanced MR arteriogram and venogram (USPIO+-MRAV). We will take advantage of the blooming effect from the USPIO and the shift in susceptibility to create new means to image both arterioles and venules at the 50μm to 100μm level on both 3T and 7T MRI scanners. We expect to have a clinically viable method to create a “microvascular print” of the brain's angio-architecture based on 3D vascular tracking to assess micro-vessel topology and distribution that are not available on conventional imaging. We will develop quantitative measures of vascular density and capillary density to evaluate age-related changes in a cohort of healthy volunteers aged from 18 to 85 years. If successful, this innovative technology is expected to provide fundamental insights on how age-related microvascular alteration is detected and interpreted with in vivo brain imaging.

项目摘要 /摘要：微血管动脉系统在输送氧气和 葡萄糖满足大脑的高代谢需求。最近，微血管异常已经 越来越多地确定为包括与年龄相关的痴呆在内的许多神经系统疾病的来源或基础。 如今，由于衰老而引起的结构和功能变化的机制仍然不清楚，并且 迫切需要在体内表征小船在两者中的小船只的年龄如何 男性和女性成年人。尽管MRI能够以分辨率的分辨率对大脑的结构方面进行图像 1mm今天，它尚未用于研究平面分辨率的体内人类的微血管细节 100μm或更少。我们已经开发了一种使用一种方法来修改动脉的敏感性 超小型parparamagnetic-Ion-Oxide（USPIO），使得可以对小动脉和静脉进行图像形象 具有易感性加权成像（SWI）和定量易感映射（QSM），以观看微视频 小于100μm。我们对这项建议的兴趣是将各种医学和科学的专家汇集在一起 MR物理学，图像处理和重建等领域，以开发一种新技术 超高分辨率USPIO增强的MR ARTIOGRAM和VINOGRAM（USPIO+-MRAV）。我们会接受的 USPIO的盛开效应的优势以及创造新手段形象的敏感性的转变 在3T和7T MRI扫描仪上，小动脉和静脉均处于50μm至100μm的水平。我们希望有一个 基于3D血管的临床上可行的方法，可以创建大脑血管架构的“微血管打印” 跟踪评估传统成像中无法使用的微官拓扑和分布。我们 将开发出血管密度和毛细管密度的定量测量，以评估与年龄相关的变化 18至85岁的健康志愿者队列。如果成功，这种创新的技术有望 提供有关如何检测和解释与年龄相关的微血管改变的基本见解 体内脑成像。