Immunological Mechanisms of Disease Training Program

疾病免疫机制培训计划

• 批准号: 10413896
• 负责人: AMY S MAJOR
• 金额: $ 26.32万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-08-05 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10413896
• 关键词: Disease; Immunologics; Training Programs

SUMMARY The Vanderbilt University School of Medicine Immunological Mechanisms of Disease Training Program (IMDTP) will fill a much-needed gap in the training of basic immunologic mechanisms of human disease. The clinical translation of basic science immunology to benefit human health now requires the development of scientists with appreciation of both inflammation and the tissues in which it occurs. The primary focus of the IMDTP will be to provide pre- and postdoctoral trainees with the expertise necessary to make novel discoveries in basic immunology and to translate these discoveries to human disease. The IMDTP will provide trainees a skill set to address how the immune system is regulated and functions in complex tissues in human disease by integrating basic immunology and principles of pathology with a particular emphasis on chronic, inflammatory diseases, and cancer. A long-term goal of the IMDTP will be to not only train the next generation of research scientists in basic immunology, but to emphasize the importance of using acquired knowledge as a translational platform on which to develop new therapies and interventions with a high regard for responsible conduct of research and reproducibility. We plan to use an interdisciplinary training approach building upon the Vanderbilt University program in Molecular Pathology and Immunology. The training faculty has been specifically recruited from the greater Vanderbilt scientific community conducting immunology-based research of chronic inflammatory diseases and consists of twenty-six highly productive faculty with successful mentoring records. In order to also allow for the training of future mentors, three mentors are at the Assistant Professor level. All of the faculty mentors have successful histories training predoctoral and postdoctoral scientists and have primary interests in immune- and inflammatory-based mechanisms of disease. These research programs will provide highly developed, diverse, and interdisciplinary training opportunities. All trainees will acquire and expand their skills in critical thinking, oral and written communication and interrogation of the literature. These primary functions of the IMDTP will be facilitated through our bi-weekly immunology and pathology seminar series and annual research symposium. Training will include participation in courses and modules on both basic immunology and pathology of disease processes. In addition, we will provide each trainee with the necessary instruction on responsible conduct in science, rigor and reproducibility in research and information on alternative career options. Funds are requested to support three predoctoral and two postdoctoral trainees. Thoughtful mentoring of these trainees, made possible by the IMDTP, will ensure the future of translational research focused on immunologic mechanisms of disease.

概括 范德比尔特大学医学院疾病免疫机制培训 计划（IMDTP）将填补基础免疫机制培训急需的空白 人类疾病。基础科学免疫学临床转化造福人类健康现 需要培养对炎症和炎症组织有了解的科学家 它发生了。 IMDTP 的主要重点是为博士前和博士后学员提供 在基础免疫学方面取得新发现并将其转化为必要的专业知识 人类疾病的发现。 IMDTP 将为学员提供一套技能，以解决免疫问题 系统通过整合基本功能在人类疾病的复杂组织中受到调节和发挥作用 免疫学和病理学原理，特别强调慢性、炎症 疾病和癌症。 IMDTP 的长期目标不仅是培养下一代 研究基础免疫学的科学家，但要强调使用获得性免疫学的重要性 知识作为一个转化平台，在此基础上开发新的疗法和干预措施 高度重视负责任的研究行为和可重复性。我们计划使用一个 以范德比尔特大学分子课程为基础的跨学科培训方法 病理学和免疫学。培训师资是专门从大专院校招聘的 范德比尔特科学界正在进行基于免疫学的慢性炎症研究 疾病，由二十六名具有成功指导记录的高产教师组成。在 为了也可以培训未来的导师，助理教授有三名导师 等级。所有的导师都有成功培养博士前和博士后的经历 科学家，主要对基于免疫和炎症的疾病机制感兴趣。 这些研究项目将提供高度发达、多样化和跨学科的培训 机会。所有学员都将获得并扩展批判性思维、口头和书面技能 文献的交流和询问。 IMDTP 的这些主要功能是 通过我们每两周一次的免疫学和病理学研讨会系列和年度研究来促进 座谈会。培训将包括参加基础免疫学和免疫学方面的课程和模块 疾病过程的病理学。此外，我们将为每位学员提供必要的 关于研究和信息的科学性、严谨性和可重复性的负责任行为的指导 另类职业选择。申请资金支持三名博士前和两名博士后 实习生。 IMDTP 为这些学员提供周到的指导，将确保他们的未来 转化研究的重点是疾病的免疫机制。