DiCAYA: South Carolina Youth (Component A)

DiCAYA：南卡罗来纳州青年（A 部分）

• 批准号: 10413795
• 负责人: ANGELA D LIESE
• 金额: $ 45万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-30 至 2025-09-29
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10413795
• 关键词: DiCAYA; South; Carolina; Youth; Component

PROJECT SUMMARY Between 2001 and 2009, the multi-site SEARCH for Diabetes in Youth study documented marked increases in the incidence and prevalence of type 1 diabetes (T1D) and type 2 diabetes (T2D) among youth. These trends were largely driven by increased incidence rates in racial and ethnic minorities. Ongoing surveillance of diabetes diagnosed in youth is essential to inform health care systems and generate testable hypotheses related to the natural history of diabetes in youth, but it cannot be accomplished through existing national survey-based surveillance efforts because of the rarity of diabetes in youth. Therefore, in response to RFA-DP- 20-001, Component A, we propose the South Carolina DiCAYA Youth study, which will ascertain newly- diagnosed incident diabetes cases statewide throughout the study period. Our approach is informed by almost 20 years of experience in South Carolina that allows us to conduct diabetes surveillance work in youth in a highly efficient manner, relying on a novel 2-step approach developed by our team which builds on electronic health record (EHR) data. Our specific aims are: Aim 1: To ascertain newly-diagnosed cases of incident diabetes in youth < 18 years of age in 2020 - 2024 in order to describe diabetes incidence in South Carolina, by age, sex, race/ethnicity, and diabetes type. Aim 2: To provide annual estimates of the prevalence of diabetes in youth < 18 years, by age, sex, race/ethnicity, and diabetes type, using mathematical modeling and the ascertained incidence data. South Carolina is uniquely positioned to contribute to the DiCAYA surveillance effort by employing our well-established surveillance infrastructure that has been refined for optimal efficiency while maintaining our exceptional levels of scientific rigor and ascertainment completeness. Moreover, we are comprised of a highly-experienced, collaborative and multi-disciplinary investigative team. Last but not least, South Carolina’s location in the South Atlantic census division and high proportion of non- Hispanic black residents will be critical to guaranteeing the representativeness of the overall DiCAYA surveillance effort, as South Carolina has contributed 21% of all incident T1D cases (48% of non-Hispanic black T1D) and 32% of all incident T2D cases (70% of non-Hispanic black T2D) to surveillance conducted by SEARCH. Thus, the well- established and highly- productive South Carolina team is uniquely positioned to provide critical information on the prevalence and incidence of diabetes in youth.

项目摘要 在2001年至2009年之间，青年研究中对糖尿病的多站点搜索有明显的增加 年轻人中1型糖尿病（T1D）和2型糖尿病（T2D）的事件和患病率。这些趋势 在很大程度上是由于种族和少数民族的发病率提高所致。正在进行的监视 在青年中诊断出的糖尿病对于告知医疗保健系统并产生可检验的假设至关重要 与青年糖尿病的自然史有关，但不能通过现有国家来实现 基于调查的监视工作是由于青年糖尿病的稀有性。因此，响应RFA-DP- 20-001，组件A，我们提出了南卡罗来纳州迪卡亚青年研究，该研究将确定新近 - 在整个研究期间，已诊断出已诊断出的事件糖尿病病例。我们的方法几乎被告知 南卡罗来纳州的20年经验使我们能够在年轻人中进行糖尿病监测工作 高效的方式，依靠我们的团队开发的一种新颖的2步方法，该方法以电子为基础 健康记录（EHR）数据。我们的具体目的是：目标1：确定新事件的新诊断案件 青年糖尿病在2020年至2024年<18岁，以描述南卡罗来纳州的糖尿病发病率 按年龄，性别，种族/种族和糖尿病类型。目标2：提供年度估计 年龄，性别，种族/种族和糖尿病类型的青年糖尿病<18岁，使用数学建模和 确定的事件数据。南卡罗来纳州的独特位置有助于为dicaya监视做出贡献 通过采用我们公认的监视基础设施来进行的努力，该基础设施已被完善以达到最佳效率 同时保持我们的科学严谨性和确定性的完整性。而且，我们是 完成了一支经验丰富，协作和多学科的调查团队。最后但并非最不重要的， 南卡罗来纳州在南大西洋人口普查部门的位置和非西班牙裔黑 居民对于保证总体DICAYA监视工作的代表性至关重要，因为 南卡罗来纳州贡献了所有事件T1D病例的21％（占非西班牙裔黑色T1D的48％）和所有事件的32％ 通过搜索进行监视的事件T2D病例（非西班牙裔黑色T2D的70％）。那是一个好人 建立且产生高度生产的南卡罗来纳州团队在提供有关关键信息的独特位置 青年糖尿病的患病率和发病率。