Interconnections among Cognition, Pain, and Physical Function in Aging.

衰老过程中认知、疼痛和身体功能之间的相互联系。

• 批准号: 10409792
• 负责人: Thomas W Buford
• 金额: $ 10.49万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10409792
• 关键词: Address; Advisory Committees; Affective; Age; Aging; Alabama; Alzheimer' s Disease; Area; Award; Biometry; Brain; Chronic; Chronic low back pain; Cognition; Cognition Disorders; Cognitive; Cohort Studies; Collaborations; Complex; Coupled; Creativeness; Data; Data Collection; Data Sources; Degenerative polyarthritis; Dementia; Development; Doctor of Philosophy; Educational Curriculum; Educational workshop; Elderly; Epidemic; Exercise; Funding; Future; Gait speed; Goals; Health; Hypertension; Independent Scientist Award; Interdisciplinary Study; International; Knowledge; Knowledge acquisition; Laboratories; Lead; Leadership; Learning; Literature; Maintenance; Medicine; Mentors; Methods; Morbidity - disease rate; National Institute on Aging; Neck; Outcome; Oxygen; Pain; Pain Threshold; Pain management; Persons; Pharmacological Treatment; Physical Exercise; Physical Function; Pilot Projects; Population; Positron-Emission Tomography; Prospective Studies; Psychology; Psychosocial Factor; Publications; Quality of life; Race; Randomized Controlled Trials; Reading; Recording of previous events; Research; Research Personnel; Science; Scientist; Sensory; Site; Testing; Therapeutic; Time; Training; Training Programs; Universities; Virginia; age related cognitive disorder; biopsychosocial; career; chronic pain relief; cognitive function; cognitive neuroscience; design; disability; experience; health management; healthy aging; improved; indexing; innovation; interdisciplinary approach; knee pain; laboratory experience; meetings; mid-career faculty; mild cognitive impairment; mortality; novel; opioid abuse; pain reduction; preservation; prevent; programs; prospective; research study; skill acquisition; skills; success; symposium; therapy design; Address; Advisory Committees; Affective; Age; Aging; Alabama; Alzheimer' s Disease; Area; Award; Biometry; Brain; Chronic; Chronic low back pain; Cognition; Cognition Disorders; Cognitive; Cohort Studies; Collaborations; Complex; Coupled; Creativeness; Data; Data Collection; Data Sources; Degenerative polyarthritis; Dementia; Development; Doctor of Philosophy; Educational Curriculum; Educational workshop; Elderly; Epidemic; Exercise; Funding; Future; Gait speed; Goals; Health; Hypertension; Independent Scientist Award; Interdisciplinary Study; International; Knowledge; Knowledge acquisition; Laboratories; Lead; Leadership; Learning; Literature; Maintenance; Medicine; Mentors; Methods; Morbidity - disease rate; National Institute on Aging; Neck; Outcome; Oxygen; Pain; Pain Threshold; Pain management; Persons; Pharmacological Treatment; Physical Exercise; Physical Function; Pilot Projects; Population; Positron-Emission Tomography; Prospective Studies; Psychology; Psychosocial Factor; Publications; Quality of life; Race; Randomized Controlled Trials; Reading; Recording of previous events; Research; Research Personnel; Science; Scientist; Sensory; Site; Testing; Therapeutic; Time; Training; Training Programs; Universities; Virginia; age related cognitive disorder; biopsychosocial; career; chronic pain relief; cognitive function; cognitive neuroscience; design; disability; experience; health management; healthy aging; improved; indexing; innovation; interdisciplinary approach; knee pain; laboratory experience; meetings; mid-career faculty; mild cognitive impairment; mortality; novel; opioid abuse; pain reduction; preservation; prevent; programs; prospective; research study; skill acquisition; skills; success; symposium; therapy design

Project Summary This application is for an Independent Scientist Award (K02) from the National Institute on Aging. The candidate, Dr. Thomas W. Buford, is an Associate Professor in the Department of Medicine at the University of Alabama at Birmingham. Dr. Buford has to date established a strong scientific track record in aging and the preservation of physical function. His long-term goal is to establish a sustainable research program focused on identifying and developing therapeutic strategies for the preserving physical independence among older adults. The objective of this application is to provide the candidate with the protected time necessary to acquire knowledge and skills needed to incorporate two inter-related areas, cognitive health and pain management, into his existing research program. These areas represent two major epidemics in aging including chronic opioid abuse and cognitive disorders including mild cognitive impairment, Alzheimer’s, and other dementias. While these areas are recognized as high-priorities for older adults and are associated with declining physical function, few investigators to date have routinely incorporated these factors into prospective studies concerning the preservation of physical function among older adults. Acquiring expertise in these areas will provide the candidate with a more nuanced view of the key issues surrounding the preservation of physical independence. Award activities will also lead to and expanded skillset, ultimately contributing to an improved ability to design and execute research studies capable of making meaningful impacts on the health and quality of life of older adults. The training plan includes three primary objectives which are to: 1) Acquire new knowledge and skills to the assessment and maintenance of cognition in aging, 2) acquire new knowledge and skills in the assessment and treatment of pain in older adults, and 3) advance mentoring and leadership skills necessary to support a sustainable research program. The research plan is designed to integrate with the training plan to provide the candidate with opportunities to 1) utilize established data sources to explore novel relationships between cognition/pain and indices of physical function, and 2) participate in prospective data collection to learn laboratory methods in these areas and generate novel data in these areas. His advisory team includes established, well-funded experts in both cognition (Ronald Lazar, PhD; Virginia Wadley, PhD) and pain (Roger Fillingim, PhD, Burel Goodin, PhD) in aging as well in biostatistics (Gerald McGwin, PhD) and research leadership (Marcas Bamman, PhD). This outstanding team will facilitate the candidate’s success in integrating these new concepts with his existing research. This K02 award will provide the candidate with protected time to expand his research program which will enhance the overall creativity and sustainability of his research. Ultimately this progress is expected to enhance his potential to make significant contributions to the field of healthy aging and to improve the training of future mentees by creating a more interdisciplinary approach incorporating principles from physical, cognitive, and pain sciences.

项目摘要 该申请是获得美国国家老化研究所的独立科学家奖（K02）。这 候选人Thomas W. Buford博士是医学系的副教授 伯明翰的阿拉巴马州。 Buford博士迄今为止已经在衰老和 保存身体机能。他的长期目标是建立一个以 确定和制定治疗策略，以保护老年人的身体独立性。 本申请的目的是为候选人提供获得所需的受保护时间 合并两个相互关联领域的知识和技能，认知健康和疼痛管理， 进入他现有的研究计划。这些区域代表了衰老的两个主要事件，包括慢性 杀菌性滥用和认知障碍，包括轻度认知障碍，阿尔茨海默氏症和其他痴呆症。 虽然这些领域被认为是老年人的高优先级，并且与身体下降有关 功能，迄今为止，很少有研究人员将这些因素定期纳入有关的前瞻性研究 在老年人中保存身体功能。在这些领域获得专业知识将提供 候选人对围绕身体独立性的关键问题有更细微的看法。 奖励活动还将导致和扩大技能，最终有助于提高设计能力 并执行能够对年长的健康和生活质量产生有意义的影响的研究 成年人。培训计划包括以下三个主要目标：1）获取新知识和技能 衰老中认知的评估和维护，2）在评估中获得新知识和技能 以及老年人的疼痛的治疗，以及3）提高心理和领导能力的能力 可持续研究计划。该研究计划旨在与培训计划集成，以提供 有机会的候选人1）利用既定的数据源来探索新的关系 认知/疼痛和身体机能指标，以及2）参与预期数据收集以学习 这些领域的实验室方法并在这些领域生成新的数据。他的顾问团队包括 认知（Ronald Lazar，PhD; Virginia Wadley，PhD）和Pain（Rogen Fillingim，PhD，Burel Goodin，PhD）以及生物统计学（Gerald McGwin，PhD）和研究 领导力（Marcas Bamman，博士）。这个杰出的团队将促进候选人的成功融合 这些新概念通过他的现有研究。该K02奖将为候选人提供受保护的时间 扩大他的研究计划，以增强其研究的整体创造力和可持续性。 最终，预计这一进展将提高他为该领域做出重大贡献的潜力 健康的衰老并通过创建更跨学科的方法来改善未来月经的训练 纳入物理，认知和疼痛科学的原则。