North Carolina Translational and Clinical Science Institute (NC TraCS)

北卡罗来纳州转化与临床科学研究所 (NC TraCS)

• 批准号: 10407956
• 负责人: John Bernard Buse
• 金额: $ 994.56万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-03-30 至 2023-04-27
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407956
• 关键词: Address; Advocacy; Advocate; Attention; Basic Science; Chronic Disease; Clinical; Clinical Research; Clinical Sciences; Clinical Trials; Clinical and Translational Science Awards; Collaborations; Communities; Complex; Data; Discipline; Disclosure; Disease Management; Environment; Faculty; Fostering; Funding; Goals; Grant; Growth; Health; Health Personnel; Healthcare; Healthcare Systems; Informatics; Infrastructure; Institutes; Institution; Interdisciplinary Study; International; Investments; Lead; Leadership; Legal patent; Lesbian Gay Bisexual Transgender; Licensing; Longevity; Manuscripts; Mental Health; Mentors; Methodology; Methods; Mission; Modeling; National Center for Advancing Translational Sciences; North Carolina; Obesity; Outcome; Participant; Pathway interactions; Patients; Phase; Policies; Population; Populations at Risk; Positioning Attribute; Process; Provider; Public Health; Publications; Publishing; Reproducibility; Research; Research Infrastructure; Research Institute; Research Personnel; Research Training; Role; Rural Population; Science; Sea; Services; Small Business Innovation Research Grant; Small Business Technology Transfer Research; Substance abuse problem; Techniques; Testing; Time; Training; Translating; Translational Research; United States National Institutes of Health; Universities; Work; Workforce Development; career development; community intervention; community organizations; design; disability; ethnic minority population; evidence base; health care availability; human disease; income disparities; informatics tool; innovation; invention; literacy; low socioeconomic status; member; multi-site trial; next generation; novel; novel strategies; programs; racial minority; recruit; research study; rural counties; skills; success; tool; translational impact; translational pipeline; translational scientist

Contact PD/PI: Buse, John B Overall Abstract Since our inception in 2008, the UNC CTSA affiliate, the North Carolina Translational and Clinical Sciences Institute (TraCS) has transformed clinical and translational science at UNC through interdisciplinary research, training, collaboration with partners and stakeholders, and strong engagement across the CTSA consortium. We have built a dynamic regional network of universities, research institutes, health care providers, and >130 community organizations across our state. In the coming funding period, we propose to add NC State University in addition to RTI International and NC A&T University as full partners in our CTSA hub. Our research infrastructure has engaged 3,234 registered members, resolved 11,147 research service requests, trained 63 faculty in our KL2 program, and supported 705 pilot grants, resulting in >$170M in external research funding, and >600 published manuscripts that have been cited >21,000 times. TraCS developed Join the Conquest, an online engagement tool to increase participation in clinical trials, that includes over 6,000 registered participants and over 200 unique research studies. The TraCS 4D Strategic Initiative and KickStart Program have facilitated 141 invention disclosures, 99 patents, 40 licenses, $57M in SBIR/STTR grants, and the creation of 68 new companies. Over the next five years, we will translate the best science from UNC and across the CTSA consortium into creative, effective, and accessible clinical and community interventions, addressing the public health problems of our state and advancing national CTSA goals by completing our Overall Aims. Aim 1 Workforce Development: Develop and support a skilled and diverse clinical and translational research workforce to advance translational innovations and address healthcare priorities. Aim 2 Collaboration and Engagement: Engage diverse stakeholders as active partners in translational research, and promote innovative approaches to team science. Aim 3 Integration: Integrate translational research across the research continuum, disciplines, populations, and throughout the lifespan; Aim 4 Methods/Processes: Develop and disseminate innovative methods and approaches to address scientific and operational barriers to translating scientific findings. Aim 5 Informatics: Incorporate cutting-edge informatics tools and methodologies in every aspect of translational research. We believe that we have made exceptional strides in engaging our partners and our community in our activities and are well positioned to advance our mission as a public university CTSA. Going forward, we will further engage our stakeholders in the research process; train the next generation of translational researchers to flourish within interdisciplinary teams; effectively synergize clinical research with health care to identify unmet needs and implement solutions, particularly for populations at risk for poor health outcomes; and rapidly disseminate our findings to our patients, our community partners, and the CTSA Consortium. Project Summary/Abstract Page 176 Contact PD/PI: Buse, John B

联系PD/PI：Buse，John B 总体抽象 自2008年成立以来，UNC CTSA会员，北卡罗来纳州的翻译和 临床科学研究所（TRACS）已转化了UNC的临床和转化科学 通过跨学科研究，培训，与合作伙伴和利益相关者合作，以及 在CTSA联盟中的强大参与。我们已经建立了一个动态的区域网络 大学，研究机构，医疗保健提供者和> 130个社区组织 整个州。在即将到来的资金期间，我们建议在 除RTI International和NC A＆T大学外，还作为我们CTSA枢纽的完整合作伙伴。我们的 研究基础设施已与3234名注册成员订婚，解决了11,147个研究 服务要求，在我们的KL2计划中受过63位教职员工培训，并支持705个飞行员赠款， 导致> 1.7亿美元的外部研究资金，> 600张已出版的手稿 被引用> 21,000次。 TRACS开发了加入征服，这是一种在线参与工具 增加参与临床试验，其中包括6,000多名注册参与者及以上 200个独特的研究。 TRACS 4D战略计划和Kickstart计划已有 协助141张发明披露，99项专利，40个许可证，5700万美元的SBIR/STTR赠款和 创建68家新公司。 在接下来的五年中，我们将翻译来自UNC和CTSA的最佳科学 财团成为创造性，有效且易于获得的临床和社区干预措施， 解决我们国家的公共卫生问题，并通过 完成我们的整体目标。 AIM 1劳动力发展：发展和支持熟练的 以及多样化的临床和转化研究人员，以促进翻译创新 并解决医疗保健优先事项。目标2合作与参与：参与多样性 利益相关者是转化研究的积极合作伙伴，并促进创新方法 团队科学。 AIM 3整合：整合整个研究的翻译研究 连续性，学科，人口以及整个生命周期； AIM 4方法/过程： 开发和传播创新方法和方法来解决科学和 翻译科学发现的操作障碍。 AIM 5信息学：合并尖端 翻译研究各个方面的信息学工具和方法。 我们认为，我们在与我们的合作伙伴和社区互动方面取得了出色的进步 在我们的活动中，可以很好地推进我们作为公立大学CTSA的使命。 展望未来，我们将进一步吸引利益相关者参与研究过程；训练下一个 跨学科团队中的转化研究人员产生繁荣；有效地 与医疗保健协同临床研究，以确定未满足的需求并实施解决方案， 特别是对于患有不良健康结果的风险的人群；并迅速传播我们的发现 对于我们的患者，我们的社区合作伙伴和CTSA财团。 项目摘要/摘要页面176 联系PD/PI：Buse，John B