UCSD Alzheimer's Disease Research Centers P30

加州大学圣地亚哥分校阿尔茨海默病研究中心 P30

• 批准号: 10407977
• 负责人: JAMES B BREWER
• 金额: $ 307.04万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-05-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10407977
• 关键词: Achievement; Address; Adherence; Age; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease therapy; Amerindian; Area; Autopsy; Awareness; Biological Markers; Brain; Caregiver research; Caregivers; Chronic; Clinical; Clinical Sciences; Clinical Trials; Cognition; Cognitive; Collaborations; Communities; Complement; Country; County; Data; Data Science; Development; Diagnosis; Disease; Diverse Workforce; Education; Environment; Fostering; Functional disorder; Funding; Genetic; Goals; Heterogeneity; Image; Informatics; Institutes; Knowledge; Latino; Latino Population; Leadership; Medical; Medical Research; Methodology; Methods; Minority; Modeling; Molecular; Observation in research; Onset of illness; Participant; Pathologic; Pathway interactions; Patients; Phenotype; Plant Roots; Population Heterogeneity; Positioning Attribute; Prevalence; Psychophysiology; Public Health; Recording of previous events; Research; Research Personnel; Resources; Risk; Science; Scientist; Series; Specimen; Staging; Study models; Training; Translational Research; Underrepresented Minority; Underrepresented Populations; Ursidae Family; Work; base; clinical heterogeneity; cohort; community based participatory research; community engagement; cost; demographics; disease-in-a-dish; experience; genetic variant; imaging biomarker; induced pluripotent stem cell; innovation; interest; meetings; next generation; novel strategies; prevent; programs; ranpirnase; recruit; research study; responsible research conduct; retention rate; scientific hub; statistics; stem cell model; success; symposium; synergism; translational neuroscience; volunteer

OVERALL – SUMMARY/ ABSTRACT Alzheimer’s disease and related dementias (ADRD) together constitute a paramount and growing public health issue with tremendous cost and unfathomable aggregate suffering. Unless the diseases can be effectively treated or prevented, increased prevalence with changing demographics will lead to costs the country will find difficult to bear. Reflecting this national imperative, the National Alzheimer’s Project Act (NAPA) created a roadmap and goal to impact this disease by 2025. The current proposal for renewed funding of the UCSD Shiley-Marcos Alzheimer’s Disease Research Center (ADRC) explicitly aligns with NAPA and leverages the center’s deep roots and engagement built over the past 35 years. The center’s rich academic and community environment make it well positioned to synergize with the ADC network toward achievement of NAPA goals and milestones, particularly along the theme of examining heterogeneity of ADRD through the study of models, markers, and mechanisms in a diverse cohort of volunteers. Specifically, the center proposes work that will bring world-class advanced translational neurosciences to the study of heterogeneity and diversity in ADRD using new models and new, tailored community engagement approaches. including innovative disease in a dish models fostered by its new iPSC Core, and increased engagement with the Latino Amerindian community through the establishment of a Latino Core. Efforts are tightly integrated with functions of other cores bolstered by tremendous resources and experience gained over the center’s longstanding existence, while incorporating the most innovative, disruptive and cutting-edge science available on the multi- faceted UCSD campus. The center will achieve the following overarching aims unifying its broad-based activity in research, education, engagement, and sharing and synergizing with the ADC network: The center will 1) apply well-developed and interactive cores to foster cross-disciplinary, integrative, and innovative clinical and translational science, 2) educate and train a diverse workforce, 3) Provide a hub for scientific and community exchange and support, optimizing core efforts and synergies to best serve the local and broader patient, caregiver, and research communities and 4) engage in collaborative research across centers, with special emphasis on applying center strengths to complement the ADC network and extend its impact.

总体 - 摘要/摘要 阿尔茨海默氏病和相关痴呆症（ADRD）共同构成了最重要的公众 健康问题，巨大的成本和不可思议的痛苦。除非疾病可以 有效治疗或预防，随着人口统计的变化而增加的患病率将导致成本 国家会很难忍受。反映这一国家命令，《国家阿尔茨海默氏症》的项目法 （NAPA）创建了一个路线图和目标，以在2025年之前影响这种疾病。 UCSD Shiley-Marcos阿尔茨海默氏病研究中心（ADRC）明确与NAPA和 在过去的35年中，利用该中心的深层根源和参与度。该中心的丰富学术 和社区环境使其与ADC网络协同作用良好，以实现 纳帕的目标和里程碑，尤其是以研究ADRD的异质性的主题 研究志愿者队列中的模型，标记和机制的研究。具体而言，中心建议 将使世界一流的先进转化神经科学的工作用于异质性和 ADRD的多样性使用新的模型和新的，量身定制的社区参与方法。包括 由其新的IPSC核心培养的菜模型中的创新疾病，并增加了与拉丁裔的参与 通过建立拉丁裔核心，美洲印第安人社区。努力与功能紧密整合 在其他巨大资源和中心长期以来获得的经验得到的其他核心 存在，同时纳入了多种可取的最具创新性，破坏性和尖端的科学 刻在UCSD校园中。该中心将实现以下总体目标统一其广泛的活动 在研究，教育，参与以及与ADC网络共享和协同作用方面：中心将1） 应用良好的互动核心来培养跨学科，综合和创新的临床和 转化科学，2）教育和培训潜水员的劳动力，3）为科学和社区提供枢纽 交流和支持，优化核心努力和协同作用，以最好地为当地和更广泛的患者服务， 护理人员和研究社区以及4）与特殊的中心进行合作研究 强调应用中心优势完成ADC网络并扩大其影响。