Human iPSC Models Core
人类 iPSC 模型核心
基本信息
- 批准号:10407940
- 负责人:
- 金额:$ 67.1万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-06-01 至 2026-05-31
- 项目状态:未结题
- 来源:
- 关键词:3-DimensionalAddressAffectAfrican AmericanAgingAlzheimer&aposs DiseaseApolipoprotein EAstrocytesBiochemicalBioinformaticsBiological ModelsBiologyBiometryBlood VesselsBrainCRISPR/Cas technologyCell physiologyCellsCerebrumCollaborationsCollectionCommunitiesComplementCulture MediaDataDermalDiseaseEthnic OriginEthnic groupEventFibroblastsGene ExpressionGenome engineeringGenotypeGoalsHispanicHumanIndividualInduced pluripotent stem cell derived neuronsInstitutionKnowledgeLaboratoriesLipoproteinsMicrogliaModelingMolecularMultiomic DataMutationNeuronsNucleosome Core ParticleOrganoidsOutcomeParticipantPathogenicityPathologicPatientsPeripheral Blood Mononuclear CellPhasePhenotypePropertyProtein IsoformsProteomicsProtocols documentationResearchResourcesSeriesSiteSomatic CellSourceStructural BiochemistryStructural ModelsSynapsesTREM2 geneTechniquesTechnologyTestingTrainingWorkbiobankbrain cellcell typecerebrovascularcohortdata managementengineered stem cellsgenotypic sexhuman stem cellsinduced pluripotent stem celllipidomicsmetabolomicsmultiple omicsneuroinflammationparticlestem cell modelstem cellstranscriptomics
项目摘要
PROJECT SUMMARY (APOE U19 Core E: Human iPSC Models Core)
Human somatic and stem cell models have emerged as a powerful system for modeling the complexities of
pathological gene expression, particularly in the early phase of disease. Further, human stem cells can be
differentiated into cell-types that secrete apoE and that are affected in disease, such as neurons, astrocytes,
microglia, and vascular mural cells (VMCs), as well as 3D “mini-brain” cerebral organoids. The Core E will
build upon the existing resources and technology from three institutions at the forefront of stem cell modeling of
apoE-related biology and pathobiology in AD: MCJ (Guojun Bu), WUSTL (Celeste Karch), and ISMMS (Julia
TCW) to generate a comprehensive collection of well-characterized human iPSC lines with different APOE
genotypes from deeply phenotyped patients and through isogenic conversions. The established iPSC lines
with different APOE genotypes, sex, ethnicity, and disease status will serve both this U19 and the broader
scientific community to address critical gaps in our knowledge of the effects of apoE isoforms in different
human brain cell types. In so doing, Core E will support U19 Projects and the broader scientific community by
testing a critical component of the ApoE Cascade Hypothesis (ACH): to understand the effects of apoE
isoforms on biochemical and cellular events leading to eventual phenotypic outcomes. Thus, Core E will work
synergistically with Core A, B, F, G and Projects 1-5 to address the ACH hypothesis and to become an
invaluable resource for the broader scientific community.
项目摘要(APOE U19核心E:人IPSC模型核心)
人类体细胞和干细胞模型已成为一种强大的系统,用于建模
病理基因表达,特别是在疾病的早期。此外,人类干细胞可以是
分化为秘密apoE和在疾病中受影响的细胞类型,例如神经元,星形胶质细胞,
小胶质细胞和血管壁画细胞(VMC),以及3D“迷你脑”大脑器官。核心将
基于三个机构的现有资源和技术,位于干细胞建模的最前沿
AD中与APOE相关的生物学和病理学:MCJ(Gujun BU),Wustl(Celeste Karch)和ISMMS(Julia)
TCW)与不同的APOE生成全面的特征良好的人IPSC系列
来自深层表型患者的基因型以及通过同基因转化。已建立的IPSC线
具有不同的APOE基因型,性别,种族和疾病状况将为U19服务和更广泛的服务
科学界在我们了解ApoE同工型在不同的不同的知识中解决关键差距
人脑细胞类型。这样做,核心E将支持U19项目和更广泛的科学界
测试APOE级联假设(ACH)的关键组成部分:了解APOE的影响
生化和细胞事件的同工型导致最终表型结果。核心E将起作用
与核心A,B,F,G和1-5的项目协同解决ACH假设并成为一个
对更广泛的科学界的宝贵资源。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Celeste Marie Karch其他文献
Celeste Marie Karch的其他文献
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{{ truncateString('Celeste Marie Karch', 18)}}的其他基金
Project 2: Tau metabolism: Quantifying tau half-life and secretion
项目 2:Tau 代谢:量化 tau 半衰期和分泌
- 批准号:
10493244 - 财政年份:2021
- 资助金额:
$ 67.1万 - 项目类别:
Project 2: Tau metabolism: Quantifying tau half-life and secretion
项目 2:Tau 代谢:量化 tau 半衰期和分泌
- 批准号:
10304094 - 财政年份:2021
- 资助金额:
$ 67.1万 - 项目类别:
Targeting Tau Proteoforms in Frontotemporal Dementia
额颞叶痴呆中的靶向 Tau 蛋白变体
- 批准号:
10306108 - 财政年份:2021
- 资助金额:
$ 67.1万 - 项目类别:
Defining the Mechanisms by Which MS4A Genes Regulate TREM2 in Alzheimer Disease
定义 MS4A 基因在阿尔茨海默病中调节 TREM2 的机制
- 批准号:
10202475 - 财政年份:2019
- 资助金额:
$ 67.1万 - 项目类别:
Defining the Mechanisms by Which MS4A Genes Regulate TREM2 in Alzheimer Disease
定义 MS4A 基因在阿尔茨海默病中调节 TREM2 的机制
- 批准号:
10433975 - 财政年份:2019
- 资助金额:
$ 67.1万 - 项目类别:
Defining the Mechanisms by Which MS4A Genes Regulate TREM2 in Alzheimer Disease
定义 MS4A 基因在阿尔茨海默病中调节 TREM2 的机制
- 批准号:
10640240 - 财政年份:2019
- 资助金额:
$ 67.1万 - 项目类别:
GENETIC DISRUPTION OF TAU METABOLISM IN TAUOPATHIES
TAU 病中 TAU 代谢的基因破坏
- 批准号:
9404951 - 财政年份:2013
- 资助金额:
$ 67.1万 - 项目类别:
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