Bioinformatics Core

生物信息学核心

• 批准号: 10404438
• 负责人: Matteo Pellegrini
• 金额: $ 39.22万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404438
• 关键词: Acne; Bioinformatics; Biology; Biopsy; Cells; Complex Mixtures; Data; Data Analyses; Data Set; Disease; Disease model; Familiarity; Generations; Genes; Genetic; Genomics; Human; Immune; Immune response; Individual; Inflammatory; Lead; Measures; Methodology; Modality; Modeling; Process; Research; Research Personnel; Sampling; Services; Skin; Techniques; Technology; cell type; data analysis pipeline; data integration; data tools; data visualization; disorder control; experience; genomic data; innovation; lipid metabolism; lipidome; lipidomics; member; microbiome; multiple data types; novel therapeutics; programs; repository; single cell analysis; tool; transcriptome; transcriptome sequencing; transcriptomics; two-dimensional; web site

PROJECT SUMMARY/ABSTRACT Bioinformatics Core The purpose of this Core is to provide bioinformatic analysis of transcriptomic data. Our Core will provide the essential data analysis service to render this data accessible and interpretable to the members of this consortium. The directors and staff of this Core have extensive experience in the analysis of genomic data, as well as familiarity with the underlying biology of the associated projects. Specifically, we will process bulk, single cell and spatial transcriptomic data using existing pipelines. Moreover, we have developed tools to interpret transcriptomic profiles in terms of cell type and inflammatory signatures. We also have expertise in the use of data integration tools to combine our transcriptomic data with genetic and lipidomic data. Finally, we will provide tools for data visualization, such as an R Shiny server for viewing individual genes in two dimensional projections of single cell transcriptomes. The Core we are proposing here will allow all the groups within this CORT to receive analyzed data that can be directly interpreted by researchers without extensive computational expertise. This functionality should render genomics research far more accessible to all members of this CORT.

项目摘要/摘要 生物信息学核心 该核心的目的是提供转录组数据的生物信息学分析。我们的核心将提供 基本的数据分析服务，以使此数据可访问和解释为成员 财团。该核心的董事和员工在分析基因组数据方面具有丰富的经验， 以及对相关项目的基本生物学的熟悉。具体来说，我们将处理批量， 单元和空间转录组使用现有管道。而且，我们开发了工具 用细胞类型和炎症特征来解释转录组谱。我们也有专业知识 使用数据集成工具将我们的转录组数据与遗传和脂肪组数据结合在一起。最后，我们会的 提供用于数据可视化的工具，例如用于在二维中查看单个基因的R光泽服务器 单细胞转录组的投影。我们在这里提议的核心将允许其中的所有组 Cort接收分析的数据，这些数据可以由研究人员直接解释而无需大量计算 专业知识。此功能应该使所有成员更容易使基因组学研究更加访问 科特。