P50-Admin Core-Harris/Garb

P50-管理核心-Harris/Garb

• 批准号: 10404443
• 负责人: John E Harris
• 金额: $ 21.24万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-12 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10404443
• 关键词: Achievement; Advisory Committees; Affect; Atopic Dermatitis; Autoimmune Diseases; Autoimmunity; Budgets; Caregiver research; Cell Culture Techniques; Cells; Clinical Research; Collaborations; Communication; Communities; Complex; Data; Dermatologist; Disease; Disputes; Education; Ensure; Evaluation; Event; FDA approved; Funding; General Population; Generations; Genetic Risk; Goals; Grant; Human; Human Resources; Immunologist; Individual; Information Dissemination; Insulin-Dependent Diabetes Mellitus; Knowledge; Lead; Leadership; Left; Modeling; Multiple Sclerosis; Nature; Occupational activity of managing finances; Outcome; Participant; Pathogenesis; Patients; Physicians; Population; Progress Reports; Psoriasis; Publications; RNA; Research; Research Personnel; Resolution; Resources; Rheumatoid Arthritis; Sampling; Schedule; Scientific Advances and Accomplishments; Scientist; Signal Pathway; Signal Transduction; Skin; System; T-Cell Receptor; T-Lymphocyte; Time; Tissues; Translational Research; United States National Institutes of Health; Vitiligo; White Spots; Workload; chemokine; clinical care; cohesion; collaborative environment; experience; health disparity; improved; innovation; insight; interdisciplinary approach; meetings; multidisciplinary; multiple omics; neoantigens; outreach; outreach program; psychologic; research study; risk variant; skin disorder; skin lesion; success; tool; transcriptomics; treatment strategy

Over 70 million individuals worldwide suffer from vitiligo, a psychologically devastating autoimmune disease of the skin that causes disfiguring white spots and disproportionately affects those with darker skin. This, com- bined with a lack of FDA-approved treatments for vitiligo, creates a concerning health disparity for some of the most vulnerable of our population. Because of the accessibility of the skin, vitiligo provides a unique oppor- tunity for detailed, innovative translational research studies that provide insight into its pathogenesis and lead to improved treatment strategies. Further, vitiligo shares genetic risk alleles and other mechanisms with auto- immune diseases that are more complex and/or difficult to study using translational tools and thus provides an unparalleled model through which to understand mechanisms of human autoimmunity. We have generated preliminary data using a translational multi-omics approach that reveal thousands of new data points marking hundreds of new signaling pathways that coordinate autoimmunity in the skin during viti- ligo. What remains lacking, however, is an integrated, multidisciplinary approach to assemble this new data into a comprehensive understanding of disease pathogenesis within vitiligo skin lesions. Thus, there is a critical need to establish a coordinated, collaborative effort to reveal new, high-resolution insight into the pathogenesis of vitiligo and other autoimmune diseases that could support innovative, advanced treatment strategies. We will leverage our existing data, leading multidisciplinary investigative team, and cutting-edge research tools to accomplish this task within the Vitiligo Center of Research Translation (VCORT). Strong communication, coordination, fiscal management, education, and dissemination of information will be critical to the success of this multidisciplinary effort. The overall objective of the Administrative Core is to serve as an interface among VCORT participants to promote the generation and dissemination of knowledge among the collaborative inves- tigators, the broader scientific community, and the public. We will do this through the following specific aims: 1) Manage internal and external communication; 2) Advance scientific endeavors and ensure achieve- ment of specific milestones; 3) Effectively manage financial resources and ensure compliance. Thus, the Core will remove administrative and financial duties from the workload of VCORT scientists, allowing them to focus on research. The expected outcome is to have established and maintained a VCORT through which exceptional transla- tional science is conducted in a diverse, informed, and highly collaborative environment. This will have an im- portant positive impact on patients, caregivers, and the research community through progress toward under- standing and treating vitiligo, as well as establishing strong collaborations to expand the field of translational research in vitiligo and human autoimmunity.

全世界有超过7000万个人患有白癜风，这是一种心理毁灭性的自身免疫性疾病 导致毁容白点并过度影响皮肤较暗的皮肤。这个，com- 由于缺乏FDA批准的白癜风治疗方法，对某些人的健康差异产生了一种 最容易受到我们人口的影响。由于皮肤的可及性，白癜风提供了独特的oppor- 用于详细的创新翻译研究，可洞悉其发病机理并领导 改善治疗策略。此外，白癜风与自动共享遗传风险等位基因和其他机制 使用翻译工具更复杂和/或难以研究的免疫疾病，因此提供了 无与伦比的模型，通过这些模型了解人类自身免疫的机制。 我们已经使用翻译多词的方法生成了初步数据，该方法揭示了数千种新的数据 数据点标记了数百种新的信号通路，这些信号通路是在viti期间协调皮肤自身免疫性的数据 Ligo。然而，仍然缺乏一种集成的多学科方法来组装这些新数据 深入了解白癜风皮肤病变内的疾病发病机理。因此，有关键 需要建立协调的协作努力，以揭示对发病机理的新的高分辨率见解 白癜风和其他可以支持创新的先进治疗策略的自身免疫性疾病。 我们将利用现有数据，领导多学科调查团队和尖端的研究工具 为了完成研究翻译中心（VCORT）中的这项任务。强烈的沟通， 协调，财政管理，教育和信息传播对成功至关重要 这项多学科的工作。行政核心的总体目标是作为界面 vcort参与者促进合作企业中知识的产生和传播 - 老虎，更广泛的科学界和公众。我们将通过以下特定来做到这一点 目的：1）管理内部和外部交流； 2）提高科学努力并确保取得成就 - 特定里程碑； 3）有效管理财务资源并确保合规。因此，核心 将从Vcort科学家的工作量中删除行政和财务职责，使他们能够集中精力 研究。 预期的结果是建立和维护了一个vcort，通过该vort Tional Science是在多样化，知情和高度协作的环境中进行的。这将有一个 通过在不足的过程中进步，对患者，看护人和研究界的积极影响 站立和治疗白癜风，并建立强大的合作以扩大转化领域 白癜风和人类自身免疫的研究。