Integrative Health Sciences Facility Core

综合健康科学设施核心

基本信息

批准号：
10400882
负责人：
Ivan Rusyn
金额：
$ 22.1万
依托单位：
TEXAS A&M UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2019
资助国家：
美国
起止时间：
2019-05-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10400882
关键词：
3-Dimensional Address Affect Amendment Animal Model Animals Area Basic Science Biological Models Cells Center for Translational Science Activities Chemical Exposure Clinical Communities Consult Consultations Core Facility County Data Databases Disease Disease susceptibility Doctor of Philosophy Early Diagnosis Early treatment Engineering Ensure Environmental Health Epidemiologist Epidemiology Equipment Exposure to Familiarity Fostering Funding Genes Goals Health Health Sciences Human Human Resources IACUC Ii-Key In Vitro Institutional Review Boards Integrative Medicine Interdisciplinary Study International Intervention Studies Knock-out Milieu Therapy Mission Modeling Mus National Institute of Environmental Health Sciences Organoids Personnel Staffing Pilot Projects Population Positioning Attribute Prevention Procedures Protocols documentation Public Health Research Research Design Research Personnel Research Project Grants Research Support Resources Risk Role Science Scientist Services Structure System Technology Texas Tissue Microarray Toxicology Transgenic Model Transgenic Organisms Translational Research Universities Work authority base cohort community based research community engagement epidemiology study experience experimental study human capital human disease improved in vitro Model instrumentation meetings member novel operation outreach population based population health programs public health research research facility stem cells tissue culture tool translational study voucher

项目摘要

Integrative Health Sciences Facility Core (IHSFC) ABSTRACT The Texas A&M Center for Environmental Health Research (TiCER) is focused on “Enhancing Public Health by Identifying, Understanding and Reducing Adverse Environmental Health Risks.” The IHSFC will be the major driver to fulfill the mission of the Center: to identify and address environmental health concerns through multidisciplinary collaborations among Center members and other stakeholders. IHSFC fulfills the mandate for the Environmental Health Sciences Core Centers to provide “facilities and resources to accelerate research along the spectrum from basic mechanistic and toxicological science to population and public health and dissemination.” The goal of IHSFC is to facilitate bi-directional translational studies ranging from research in the community-based human cohorts, to population-based experimental studies in mice and human cells, to microphysiological in vitro systems. This goal will be accomplished by integrating the Center’s translational research into causes and mechanisms of environmental health risks among three major areas of inquiry: (i) human community-based translational studies and databases, (ii) mouse population-based and transgenic models, and (iii) novel in vitro models. The IHSFC will be led by Dr. Ivan Rusyn, an expert in all three areas of inquiry. The human translational studies area, led by Dr. Natalie Johnson, will focus on facilitating community oriented research projects, enabling access to health and environmental information- containing databases, and consulting on IRB compliance. The mouse translational studies area, led by Dr. Ben Morpurgo, will focus on study designs and access to Collaborative Cross and RIX mouse populations, transgenic/knockout services (including CRISPR/Cas9), and IACUC compliance. The in vitro translational studies area, led by Dr. Ivan Rusyn, will focus on the use of novel microphysiological (human and mouse organoids, stem cells, and tissue chips), and population-based in vitro tools, as well as advising on biosafety compliance. The IHSFC will enable center members’ integrative research through dedicated staff in each area and a voucher-based model. The Core will provide up to $100,000 per year (½ from NIEHS and ½ from Texas A&M) to facilitate Center members’ access to and use of translational resources. The IHSFC function will include (i) close integration with the Pilot Projects Program, the Community Engagement Core, and research facility cores through monthly meetings to identify and promote integrative and translational projects, and (ii) key personnel and staff outreach to Center members to encourage and initiate projects. The IHSFC will work closely with the Administrative Core to track the Core’s operation and funding allocations and with the Pilot Projects Core to identify projects that may benefit from IHSFC expertise, equipment and resources. The IHSFC leaders have an established record of accomplishment in collaborative research among themselves and with many Center members and IHSFC is well positioned to enhance translational research bi-directionally along the spectrum from basic to community-based research to address public health challenges.

综合健康科学设施核心 (IHSFC) 摘要德克萨斯 A&M 环境健康研究中心 (TiCER) 致力于“增强公众健康” 通过识别、理解和减少不利的环境健康风险来实现健康。” 履行中心使命的主要驱动力：识别和解决环境健康问题通过中心成员和其他利益相关者之间的多学科合作，IHSFC 实现了这一目标。环境健康科学核心中心的任务是提供“加速设施和资源” 研究范围从基础机械和毒理学到人口和公共卫生 IHSFC 的目标是促进双向转化研究，包括：以社区为基础的人类队列研究，以小鼠为基础的实验研究和人体细胞，到体外微生理系统，这一目标将通过整合来实现。中心三大环境健康风险成因及机制转化研究研究领域：（i）基于人类社区的转化研究和数据库，（ii）基于小鼠群体的和转基因模型，以及 (iii) 新颖的体外模型将由 Ivan Rusyn 博士领导，他是所有领域的专家。由 Natalie Johnson 博士领导的人类转化研究领域将重点关注三个领域。促进面向社区的研究项目，使人们能够获取健康和环境信息- 包含数据库以及 IRB 合规性咨询，由 Dr. 领导。 Ben Morpurgo 将专注于研究设计以及协作杂交和 RIX 小鼠群体的获取，转基因/基因敲除服务（包括 CRISPR/Cas9）和 IACUC 合规性。由 Ivan Rusyn 博士领导的研究领域将重点关注新型微生理学（人类和小鼠）的使用类器官、干细胞和组织芯片）和基于人群的体外工具，以及生物安全建议 IHSFC 将通过各个领域的专门工作人员使中心成员能够进行综合研究。基于优惠券的模式每年将提供高达 100,000 美元（NIEHS 提供 1/2，德克萨斯州提供 1/2）。 A&M），以促进中心成员访问和使用翻译资源。 IHSFC 职能将。包括 (i) 与试点项目计划、社区参与核心和研究的紧密结合通过每月举行会议来确定和促进综合和转化项目，以及（ii） IHSFC 将与中心成员进行联系以鼓励和启动项目。与行政核心密切合作，跟踪核心的运营和资金分配，并与试点项目密切合作项目核心确定可受益于 IHSFC 专业知识、设备和资源的项目。领导者之间以及与他人合作研究方面已建立了成就记录许多中心成员和 IHSFC 都处于有利地位，可以沿着解决公共卫生挑战的从基础研究到社区研究的范围。