Training Program in Molecular Metabolism

分子代谢培训项目

• 批准号: 10398989
• 负责人: Sudha B Biddinger
• 金额: $ 19.52万
• 依托单位: HARVARD SCHOOL OF PUBLIC HEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10398989
• 关键词: Metabolism; Molecular; Training Programs

ABSTRACT The Molecular Metabolism Training Program (MMTP) at the Harvard Chan School of Public Health (HSPH) will train a new generation of academic scientists committed to conducting cutting-edge research in metabolism and metabolic disease. Central features of this program include integration of innovative platforms in ‘omics, microbiome analysis, animal physiology, imaging, and other technologies for analyzing metabolism; unique coursework in metabolism and metabolic disease, biostatistics, epidemiology, and computational analysis with a public health focus; and a collaborative faculty based at HSPH and adjacent institutions in the Longwood Medical Area. MMTP leverages the innovative training environment offered at a top public health institution, supplementing it with rigorous training in emerging molecular analysis tools. Trainees will study both individual and population aspects of disease and other unique resources offered at a school of public health. The vibrant community of twenty-one faculty mentors studies multidisciplinary questions such as the interactions between the immune system and exercise or over-nutrition; the effect of the microbiome on metabolism; the role of lipid drop or mitochondrial dynamics in metabolic homeostasis; or the effects of metabolic flux on energy metabolism in well and disease states. Research focuses on understanding the most significant challenges to global public health, including metabolic syndrome and the related lipotoxic diseases of type 2 diabetes, non-alcoholic fatty liver disease, metabolic diseases of an aging population, immunometabolism, and immune and microbiome contributions to digestive health. We are requesting funding for three new predoctoral students and one postdoctoral fellow every year, so the T32 would support twenty trainees over its five years. Pre-doctoral students will obtain a PhD in Biological Sciences in Public Health (BPH) from one of the most highly ranked public health doctoral programs in the nation. BPH attracts a diverse student body and has a successful track record in supporting these students. Postdoctoral fellows will have access to coursework, mentors, and a highly interactive metabolism research community. MMTP will thus train a diverse group of interdisciplinary scientists who can apply innovative research methods to understand fundamental questions in human metabolism.

抽象的 哈佛大学学校的分子代谢培训计划（MMTP） 公共卫生（HSPH）将培训新一代的学术科学家致力于 进行代谢和代谢疾病的尖端研究。 计划包括在“ OMIC，微生物组分析，动物”中集成创新平台 生理学，成像和其他分析新陈代谢的技术； 新陈代谢和代谢疾病，生物统计学，流行病学和计算分析 公共卫生的重点； 朗伍德医疗区。 MMTP利用了顶级公共卫生提供的创新培训环境 在新兴的分子分析工具中进行严格的培训，以补充它 将研究疾病的个人和人口方面以及其他独特的资源 在公共卫生学校。 多学科的问题，例如免疫系统与锻炼之间的相互作用或 过度核能；微生物组的作用 代谢稳态的动力学或代谢通量对能量代谢的影响 疾病的研究重点是理解 全球公共卫生，含有代谢综合征和2型的相关脂肪毒性探测 糖尿病，非酒精性脂肪肝病，人口老龄化的代谢疾病， 免疫代谢，免疫和微生物组对消化健康的贡献。 我们要求三个新的前学生和一名博士后 每年，T32将在五年内支持二十个培训 学生将从最多的一项中获得公共卫生生物科学博士学位（BPH） 在国家中排名较高的公共卫生博士课程。 并在支持这些学生方面拥有成功的记录。 进入课程，导师和高度互动的代谢研究社区。 MMTP将培训一组可以应用创新性的跨学科科学家 了解人类代谢中基本问题的研究方法。