The Evidence Project: Systematic Reviews of Critical HIV Interventions, and Disruption in HIV Services from COVID-19 in LMIC

证据项目：中低收入国家关键艾滋病毒干预措施的系统审查以及 COVID-19 对艾滋病毒服务造成的干扰

• 批准号: 10395612
• 负责人: Michael D Sweat
• 金额: $ 48.63万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-20 至 2026-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10395612
• 关键词: AIDS prevention; Address; Adherence; Africa; Appointment; Area; Attention; Behavior; Behavioral; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 pandemic effects; Caring; Centers for Disease Control and Prevention (U.S.); Characteristics; Client; Code; Collaborations; Communities; Conflict (Psychology); Consensus; Cost Analysis; Data; Decentralization; Development; Effectiveness; Government; Grant; Guidelines; HIV; Health; Health Services Accessibility; Home; Information Retrieval; Intervention; Intervention Studies; Investments; Journals; Lead; Link; Literature; Maps; Mental Health; Meta-Analysis; Methods; Modeling; Outcome; Paper; Participant; Patients; Peer Review; Pharmaceutical Preparations; Policies; Population; Prevention; Public Health; Publications; Publishing; Reaction; Reporting; Reproductive Health; Research; Research Design; Resources; Risk; Role; Scientist; Services; Sexual Health; Shock; Techniques; Time; Training; Training Programs; Translational Research; United States National Institutes of Health; Update; Ursidae Family; Vaccines; Work; base; commune; cost effectiveness; data repository; evidence base; experience; implementation intervention; improved; innovation; intervention effect; low and middle-income countries; mathematical model; meetings; pre-exposure prophylaxis; programs; prospective; rapid growth; repository; service delivery; social; social structure; success; systematic review; theories; therapy design; vaccine access

PROJECT SUMMARY / ABSTRACT Abstract: Despite the vast and ever-growing scientific literature on the efficacy of behavior, social, and structural interventions, interpreting the scientific literature is challenging. Identifying relevant studies is time intensive. The quality of research from published reports requires careful analysis. There are conflicting findings across studies. Metrics and study designs used across studies are typically inconsistent. Pooling results across studies also requires advanced statistical techniques. The state-of-the-art strategy to address these challenges is to use systematic reviews and meta-analyses to analyze and interpret the effects of interventions evidenced with research across multiple studies. In the prposed study we will conduct systematic reviews and meta- analyses on studies from LMIC that focus on behavioral, social, or structural interventions. There are three key areas we will analyze: (1) interventions designed to support linkage, retention, and adherence to ART and PrEP with a focus on modes of service delivery; (2) interventions that integrate non-HIV health issues with HIV- specific health issues; and (3) assessing the impact of the COVID-19 epidemic on HIV-related care and prevention in LMIC. In addition, we will add to our rigorous data extraction information on both the theoretical basis of the interventions under consideration, as well as data on the implementation characteristics of each intervention. Data extraction on implementation characteristics and theory will also be done retrospectively for all 435 studies we have previously reviewed and added to our data repository.

项目概要/摘要 抽象的： 尽管关于行为、社会和结构功效的科学文献数量庞大且不断增长， 干预措施，解释科学文献是具有挑战性的。确定相关研究非常耗时。 已发表报告的研究质量需要仔细分析。各方面存在相互矛盾的发现 研究。研究中使用的指标和研究设计通常不一致。汇集结果 研究还需要先进的统计技术。应对这些挑战的最先进的策略 是使用系统评价和荟萃分析来分析和解释干预措施的效果 通过多项研究的研究。在拟议的研究中，我们将进行系统回顾和元分析 对中低收入国家关注行为、社会或结构干预的研究进行分析。有三个关键 我们将分析的领域：(1) 旨在支持联系、保留和坚持 ART 的干预措施 PrEP 重点关注服务提供模式； (2) 将非艾滋病毒健康问题与艾滋病毒结合起来的干预措施 具体的健康问题； (3) 评估 COVID-19 流行病对 HIV 相关护理和治疗的影响 中低收入国家的预防。此外，我们还将在严格的数据提取信息中添加有关理论的信息 正在考虑的干预措施的基础，以及每项措施实施特点的数据 干涉。还将对实施特征和理论进行回顾性数据提取 我们之前审查过所有 435 项研究并将其添加到我们的数据存储库中。