Cancer Control and Survivorship

癌症控制和生存

基本信息

批准号：
10394828
负责人：
PATRICIA A. GANZ
金额：
$ 15.53万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
1996
资助国家：
美国
起止时间：
1996-12-01 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10394828
关键词：
Address Area Behavioral Behavioral Genetics Biological Breast Cancer survivor Cancer Burden Cancer Center Support Grant Cancer Control Cancer Control Research Cancer Patient Cancer Survivor Cancer Survivorship Catchment Area Child Clinical Cognitive Therapy Collaborations Complex Comprehensive Cancer Center County Diagnosis Direct Costs Disease Doctor of Philosophy Dose Environment Epidemiologic Methods Epidemiology Epigenetic Process Ethnic Origin Faculty Funding Gender Genomic approach Genomics Health Health Policy Human Papilloma Virus Vaccination Immigrant Incidence Interdisciplinary Study Intervention Intervention Studies Intervention Trial Journals Latina Population Letters Life Style Long-Term Survivors Los Angeles Low income Machine Learning Malignant Childhood Neoplasm Malignant Neoplasms Malignant neoplasm of lung Medical Oncologist Methodology Methods Molecular Morbidity - disease rate Observational Study Outcome Outcomes Research Patients Peer Review Population Populations at Risk Pregnancy Primary Prevention Psychologist Public Health Schools Publications Quality of Care Reproducibility Research Research Personnel Resource Sharing Risk Risk Factors Science Screening for cancer Sleeplessness Survivors Symptoms Tai Ji Target Populations Testing Vulnerable Populations Work adverse outcome base cancer care cancer diagnosis cancer health disparity cancer prevention cancer risk care delivery college computed tomography screening cost effectiveness design dissemination research economic indicator end of life epidemiology study ethnic diversity ethnic minority genetic risk factor health disparity high risk implementation research implementation science improved innovation inter-institutional lung cancer screening medical schools member minority children mortality programs protective factors psychologic psychosocial racial and ethnic racial and ethnic disparities safety net screening screening guidelines social socioeconomics standard of care survivorship synergism underserved community uptake vaccine acceptance

项目摘要

CANCER CONTROL AND SURVIVORSHIP RESEARCH PROGRAM (CCS) ABSTRACT For over 25 years, the UCLA Jonsson Comprehensive Cancer Center (JCCC) has produced impactful research in cancer prevention and control, spanning the entire cancer control continuum. This work is based in the Cancer Control and Survivorship (CCS) Program, which has the breadth and depth of faculty expertise to tackle existing and emerging cancer control problems using approaches from genomics, machine learning, smarter cancer prevention and screening strategies, health outcomes research, and implementation science which can guide cancer care delivery from primary prevention through end-of-life settings and can inform health policy. There are 46 members in the CCS Program representing 16 departments spanning the Fielding School of Public Health, the David Geffen School of Medicine, and the College of Letters and Sciences. As of March 1, 2019, Program support was $26,487,925 in direct cost funding, of which $3,850,239 (15%) was from the NCI and $12,843,034 (48%) was peer-reviewed. Program research resulted in 1,127 publications between 2013-2018, of which 21% were intra-programmatic and 13% were inter-programmatic collaborations, with extensive use of the BASE shared resource. Also, 73% of total publications were inter-institutional collaborations, with 34% of the total in high-impact (IF ≥10, or field leading) journals. The CCS Program has three specific aims. Aim 1: To identify risk and protective factors for cancer as well as the most effective strategies for reducing cancer risk in the population. Aim 2: To determine the best methodologies for cancer screening and diagnosis and to identify the most effective strategies to increase uptake of cancer screening at the population level. Aim 3: To conduct research with findings that have the potential to reduce avoidable morbidity and mortality among patients with cancer and long-term survivors of cancer. CCS research is informed by, and highly responsive to, the cancer burden and needs of the JCCC catchment area, Los Angeles County (LAC). The county cancer burden is high, with large differences in cancer risk factors and cancer outcomes by ethnicity, gender, and socio-economic indicators. Thus, cross cutting themes that address health disparities and improvements in health outcomes permeate the research conducted by CCS investigators. Examples of impactful program research in the prior project period include: (1) Research showing very low rates of HPV vaccination for low income, ethnic minority adolescents in safety-net settings, resulting in multiple trials to improve vaccine uptake. (2) A study demonstrating the cost effectiveness of low-dose lung cancer CT screening that influenced the national dialog on lung cancer screening guidelines. (3) Findings that incidence rates for several childhood cancers among children of US born Latinas were higher than for children of immigrant Latinas, implicating lifestyle and environment during pregnancy. (4) A study in breast cancer survivors with severe insomnia showing that standard-of-care cognitive behavioral therapy-insomnia (CBT-I) or Tai Chi Chih (TCC) were both effective, but access to CBT-I therapists is limited, whereas TCC is widely accessible.

癌症控制与生存研究计划（CCS）抽象的超过25年，加州大学洛杉矶分校乔森森综合癌症中心（JCCC）进行了有影响力的研究在癌症预防和控制中，跨越了整个癌症控制连续性。这项工作基于癌症控制和生存计划（CCS）计划，具有教师专业知识的广度和深度来解决现有使用基因组学，机器学习，更智能癌症的方法来控制癌症控制问题预防和筛查策略，健康成果研究和实施科学，可以指导从初级预防到生命终止环境的癌症护理可以为卫生政策提供信息。 CCS计划中有46个成员，代表16个部门，跨越了公立学校健康，大卫·格芬医学院和文学和科学学院。截至2019年3月1日，计划支持为$ 26,487,925的直接成本资金，其中3,850,239美元（15％）来自NCI，并且 $ 12,843,034（48％）进行了同行评审。计划研究导致2013 - 2018年之间有1,127个出版物 21％是截面性的，有13％是程序间合作，广泛使用了基本共享资源。此外，总出版物中有73％是机构间合作，其中34％在高影响力（如果≥10或田间引导）期刊中。 CCS计划具有三个具体目标。目标1：确定癌症的风险和保护因素降低人群癌症风险的最有效策略。目标2：确定最好的癌症筛查和诊断的方法，并确定增加摄取的最有效策略在人群水平上进行癌症筛查。目的3：进行研究，发现有可能降低癌症患者和癌症长期存活的可避免的发病率和死亡率。 CCS 研究是由癌症的癌症和JCCC集水区的需求告知的，并且高度敏感洛杉矶县（LAC）。伯恩县癌症很高，在癌症危险因素和种族，性别和社会经济指标的癌症结果。那是解决问题的交叉切割主题健康分布和健康结果的改善渗透了CCS研究人员进行的研究。上一项项目期间有影响力的计划研究的示例包括：（1）研究表明利率非常低的研究 HPV疫苗接种的低收入，少数民族青少年在安全网络中的疫苗接种，导致多次试验改善疫苗的摄取。（2）一项研究表明低剂量肺癌CT的成本效益影响肺癌筛查指南的全国对话的筛查。（3）该事件的发现我们出生的拉丁裔儿童中几种童年癌的发生率高于移民儿童拉丁裔，暗示怀孕期间的生活方式和环境。（4）一项研究乳腺癌生存的研究严重的失眠表明，护理标准的认知行为疗法 - Insomnia（CBT-I）或Tai Chi Chih （TCC）都是有效的，但是访问CBT-I治疗师是有限的，而TCC可以广泛使用。