Childhood Asthma in Urban Settings

城市环境中的儿童哮喘

基本信息

批准号：
10393042
负责人：
PAULA J BUSSE
金额：
$ 43.28万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2021
资助国家：
美国
起止时间：
2021-04-15 至 2028-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10393042
关键词：
Address Adolescent Adolescent obesity Allergens Allergic Disease Area Arginine Asthma Atopic Dermatitis Blood Caring Child Childhood Childhood Asthma Clinical Clinical Research Cutaneous Data Dietary Supplementation Disease Ensure Environmental Exposure Epidemiology Equilibrium Ethnic Origin Extrinsic asthma Funding Future Health system Healthcare Systems Hospitals Hypersensitivity Immune response Immunology Impairment Individual Inflammation Intervention Intervention Studies Laboratories Laboratory Technicians Lead Literature Microbe Minority Groups Morbidity - disease rate National Institute of Allergy and Infectious Disease New York City Nitric Oxide Nurses Obesity Outcome Pathogenicity Pathway interactions Pattern Pharmacists Phenotype Population Populations at Risk Positioning Attribute Poverty Process Proteomics Protocols documentation Research Research Contracts Research Personnel Research Project Grants Risk Risk Factors Sampling Self Management Severity of illness Site Skin Systems Biology United States National Institutes of Health Urban Population Work airway inflammation base burden of illness comorbidity experience health care disparity high risk high risk population improved innovation interest member metropolitan microbiome mortality novel novel therapeutics personalized therapeutic programs prospective recruit research study respiratory success support network transcriptomics urban children urban minority urban setting

项目摘要

The overall objective of this study is to provide the NIAID Childhood Asthma in Urban Settings Clinical Research Network Center (CAUSE) with a highly developed and experienced Clinical Research Center (CRC) at the Mount Sinai Health Care System. We propose that the Mount Sinai Health Care System is well- positioned and prepared to create a NIAID CAUSE-CRC to conduct Network and Center-specific studies based upon: 1) Our success recruiting and retaining subjects in asthma studies from urban populations; 2) Investigators actively conducting innovative research to understand mechanisms of atopic diseases; 3) Established and well-organized clinical research programs with committed staff to conduct research studies; 4) Facilities and institutional support to ensure the success of this proposal; and 5) A large population of high risk urban children/adolescents with asthma who receive care and participate in research at the Mount Sinai Health System. The proposed Mount Sinai CAUSE-CRC includes a team of investigators with strong backgrounds relevant to asthma, allergy, immunology, epidemiology, transcriptomics, microbiome, and systems biology who have previously collaborated. MPIs Drs. Busse, Bunyavanich and Wisnivesky have served as PIs on several NIH and PCORI-sponsored asthma and allergic diseases networks (including ICAC-II, III sub-studies) and individually funded studies investigating determinants of asthma self-management, disparities in care, mechanisms of airway inflammation, -omics, and systems biology. The Mount Sinai CRC is supported by Co- Investigators Drs. Wright and Miller who have extensive experience in pediatric asthma network studies. Our team includes research coordinators, nurses, laboratory technicians, statisticians, bioinformaticians, pharmacists, and regulatory members who have worked with the investigators which will allow us to successfully recruit, conduct protocols, maintain the integrity of study data, and coordinate with the LC and Contract Research Organizations. Our Center-specific project 1, will investigate the influence of concurrent AD on asthma control in urban children and will be conducted with Dr. Guttman-Yassky, an expert in atopic dermatitis at Mount Sinai. Project 2 will investigate the association between L-Arginine/Asymmetric Dimethyl Arginine and asthma morbidity in obese urban adolescents with asthma. Our individual research projects provide novel information on the mechanisms and a future treatment approach with a more precise benefit in children with asthma and AD in an urban setting.

本研究的总体目标是提供 NIAID 儿童哮喘在城市环境中的临床研究研究网络中心（CAUSE）拥有高度发达且经验丰富的临床研究中心（CRC）在西奈山医疗保健系统。我们建议西奈山医疗保健系统良好- 定位并准备创建 NIAID CAUSE-CRC 来开展网络和中心特定研究基于： 1) 我们成功地从城市人群中招募和留住哮喘研究对象； 2）研究人员积极开展创新研究，以了解特应性疾病的机制； 3）已建立且组织良好的临床研究计划，并配备致力于开展研究的工作人员； 4）确保该提案成功的设施和机构支持； 5) 大量高风险人群在西奈山健康中心接受护理并参与研究的城市患有哮喘的儿童/青少年系统。拟议的西奈山 CAUSE-CRC 包括一支具有强大背景的调查人员团队与哮喘、过敏、免疫学、流行病学、转录组学、微生物组和系统生物学相关的之前有过合作。 MPI 博士。 Busse、Bunyavanich 和 Wisnivesky 曾担任多个项目的 PI NIH 和 PCORI 赞助的哮喘和过敏性疾病网络（包括 ICAC-II、III 子研究）以及单独资助的研究调查哮喘自我管理的决定因素、护理差异、气道炎症、组学和系统生物学的机制。西奈山 CRC 得到 Co- 的支持研究人员博士。 Wright 和 Miller 在儿科哮喘网络研究方面拥有丰富的经验。我们的团队包括研究协调员、护士、实验室技术员、统计学家、生物信息学家、药剂师以及与研究人员合作过的监管成员，这将使我们能够成功招募、执行方案、维护研究数据的完整性并与 LC 和合同研究组织。我们中心的具体项目1，将调查并发AD的影响关于城市儿童哮喘控制的研究，将由特应性专家 Guttman-Yassky 博士进行西奈山皮炎。项目 2 将研究 L-精氨酸/不对称二甲基之间的关联肥胖城市哮喘青少年的精氨酸和哮喘发病率。我们的个人研究项目提供有关机制和未来治疗方法的新信息，并具有更精确的益处城市环境中患有哮喘和 AD 的儿童。