Environmental bisphenol exposure, infant brain and behavior: Human and animal models

环境双酚暴露、婴儿大脑和行为：人类和动物模型

• 批准号: 10393372
• 负责人: AMY MARGOLIS
• 金额: $ 63.96万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-09-10 至 2023-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10393372
• 关键词: Address; Administrative Supplement; Adverse effects; Affect; Animal Model; Animals; Architecture; Attention; Birth; Brain; COVID-19; COVID-19 pandemic; Child; Child Health; Clinic; Clinical; Cohort Studies; DSM-V; Data; Data Collection; Development; Diagnosis; Dimensions; Discipline of obstetrics; Discrimination; Drowsiness; Economically Deprived Population; Electroencephalography; Environmental Health; Etiology; Exposure to; Functional Magnetic Resonance Imaging; Funding; Goals; Health; Home; Hospitals; Human; Individual; Infant; Infant Health; Infrastructure; Interview; Investigation; Joints; Latinx; Link; Literature; Low income; Maternal Health; Measures; Mental Depression; Mental Health; Monitor; Mothers; Neighborhoods; Nervous System Physiology; Neurophysiology - biologic function; New York City; Outcome; Outcome Measure; Parents; Patient Self-Report; Perinatal; Pittsburgh Sleep Quality Index; Polysomnography; Population; Postpartum Depression; Postpartum Period; Pregnancy; Pregnant Women; Presbyterian Church; Prevention program; Questionnaires; Race; Reporting; Risk; Risk Factors; Role; Sampling; Sleep; Sleep Stages; Sleep disturbances; Stress; Structural Racism; Structure; Surveys; Symptoms; Testing; Underrepresented Populations; Woman; actigraphy; behavioral health; brain behavior; center for epidemiological studies depression scale; clinically significant; cohort; depressive symptoms; disadvantaged background; ethnic disparity; ethnic minority population; experience; financial incentive; high risk; human model; individualized prevention; interest; intervention program; maternal caregiving; maternal outcome; mental function; negative affect; neural correlate; offspring; pandemic disease; perinatal mental health; perinatal period; peripartum depression; poor sleep; prenatal; preventive intervention; psychosocial; racial and ethnic; racial discrimination; racial minority; recruit; reward circuitry; satisfaction; sleep health; sleep quality

This proposal leverages the infrastructure of longitudinal birth cohort study (the Fair Start Cohort within the Columbia Center for Children's Environmental Health) and supplements our investigation of the effects of prenatal bisphenol (BP) exposure on infant nervous system functioning and attention and maternal caregiving (R01ES030950) within the cohort. Prior animal studies show adverse effects of BP exposure on offspring brain development and mother-infant interaction; the R01 seeks to extend these findings to humans. This Administrative Supplement investigates the effects of exposure to experiences of discrimination and COVID- 19-related stress on peripartum depression (PeriPD) and sleep health in these same women. PeriPD and sleep disturbances are common in the perinatal period and negatively affect mother-infant interaction and child health outcomes. Nonetheless etiology of PeriPD and poor sleep health are unclear. Experiences of discrimination and COVID-19-related stress, which burden disproportionately people from racial/ethnic minority and economically disadvantaged backgrounds, have been shown to increase the risk for poor mental and sleep health. Nonetheless, their independent and synergistic role in the perinatal period has not been thoroughly investigated. Understanding upstream risk factors for maternal perinatal mental health and sleep health may provide actionable information to develop prevention and intervention strategies. The funded R01 recruits pregnant women from low income, ethnic/racial minority backgrounds from obstetric clinics associated with Columbia Presbyterian Hospital. In this underrepresented population, the risk for PeriPD and poor sleep health is high. This proposal will fund the assessment of PeriPD (self-report of symptoms, prenatal psychiatric interview), neural correlates of PeriPD (fMRI), and subjective and objective measures of sleep health (self- report of sleep quality, 1-week actigraphy, and 2 days sleep EEG monitoring). We will then investigate associations between experiences of discrimination and COVID-19-related stress and the measured outcomes in a sample of Latinx women from low income backgrounds who are at high risk of exposure to discrimination and COVID-19-related stress. We hypothesize that increased exposure to discrimination and COVID-19- related stress will be associated with increased depression and poorer sleep health in the postpartum period. Our plan is consistent with goals of the Notice of Special interest NOT-OD-21-071 targeting “psychosocial and behavioral health risk factors related to the COVID-19 pandemic that affect maternal mental health and functioning outcome and the impact of structural racism and discrimination (SRD) on maternal health outcomes in the context of COVID-19”. This proposal fills a critical gap in understanding the impact of discrimination and COVID-19-related stress on PeriPD and sleep in mothers from low income, ethnic/racial minority backgrounds at high risk of experiencing both discrimination and COVID-19-related stress.

该提案利用了纵向出生队列研究的基础设施（公平开始队列） 哥伦比亚儿童环境健康中心）并补充了我们对以下影响的调查 产前双酚 (BP) 暴露对婴儿神经系统功能、注意力和母亲护理的影响 (R01ES030950) 在该队列中之前的动物研究表明，BP 暴露对后代大脑有不利影响。 R01 试图将这些发现推广到人类身上。 行政补充调查了遭受歧视和新冠病毒经历的影响 19 这些女性的围产期抑郁症 (PeriPD) 和睡眠健康相关的压力。 睡眠障碍在围产期很常见，会对母婴互动和儿童产生负面影响 然而，PeriPD 和睡眠健康状况不佳的病因尚不清楚。 歧视和与 COVID-19 相关的压力，给少数种族/族裔带来了不成比例的负担 和经济上处于不利背景的人，已被证明会增加精神和经济状况不佳的风险 然而，它们在围产期的独立和协同作用尚未得到证实。 彻底调查了解孕产妇围产期心理健康和睡眠的上游危险因素。 健康可以提供可操作的信息来制定预防和干预策略。 从相关产科诊所招募低收入、少数族裔/种族背景的孕妇 与哥伦比亚长老会医院合作，在这个代表性不足的人群中，患有老年痴呆症和睡眠质量不佳的风险。 该提案将为 PeriPD 评估（症状自我报告、产前精神病学）提供资金。 访谈）、PeriPD 的神经相关性（fMRI）以及睡眠健康的主观和客观测量（自我评估） 睡眠质量报告、1 周体动记录仪和 2 天睡眠脑电图监测）然后我们将进行调查。 歧视经历和 COVID-19 相关压力与测量结果之间的关联 在来自低收入背景的拉丁裔女性样本中，她们遭受歧视的风险很高 我们勇敢地面对日益增加的歧视和 COVID-19 相关压力。 相关的压力会导致产后抑郁症的增加和睡眠健康状况的恶化。 我们的计划与特别利益通知 NOT-OD-21-071 的目标一致，其目标是“心理社会和 与 COVID-19 大流行相关的影响孕产妇心理健康的行为健康风险因素 功能结果以及结构性种族主义和歧视（SRD）对孕产妇健康结果的影响 该提案填补了理解歧视和歧视影响方面的一个关键空白。 低收入、少数族裔/种族背景的母亲对 PeriPD 和睡眠的 COVID-19 相关压力 遭受歧视和与 COVID-19 相关的压力的风险很高。