Environmental bisphenol exposure, infant brain and behavior: Human and animal models

环境双酚暴露、婴儿大脑和行为：人类和动物模型

基本信息

批准号：
10393372
负责人：
AMY MARGOLIS
金额：
$ 63.96万
依托单位：
COLUMBIA UNIVERSITY HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-09-10 至 2023-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10393372
关键词：
Address Administrative Supplement Adverse effects Affect Animal Model Animals Architecture Attention Birth Brain COVID-19 COVID-19 pandemic Child Child Health Clinic Clinical Cohort Studies DSM-V Data Data Collection Development Diagnosis Dimensions Discipline of obstetrics Discrimination Drowsiness Economically Deprived Population Electroencephalography Environmental Health Etiology Exposure to Functional Magnetic Resonance Imaging Funding Goals Health Home Hospitals Human Individual Infant Infant Health Infrastructure Interview Investigation Joints Latinx Link Literature Low income Maternal Health Measures Mental Depression Mental Health Monitor Mothers Neighborhoods Nervous System Physiology Neurophysiology - biologic function New York City Outcome Outcome Measure Parents Patient Self-Report Perinatal Pittsburgh Sleep Quality Index Polysomnography Population Postpartum Depression Postpartum Period Pregnancy Pregnant Women Presbyterian Church Prevention program Questionnaires Race Reporting Risk Risk Factors Role Sampling Sleep Sleep Stages Sleep disturbances Stress Structural Racism Structure Surveys Symptoms Testing Underrepresented Populations Woman actigraphy behavioral health brain behavior center for epidemiological studies depression scale clinically significant cohort depressive symptoms disadvantaged background ethnic disparity ethnic minority population experience financial incentive high risk human model individualized prevention interest intervention program maternal caregiving maternal outcome mental function negative affect neural correlate offspring pandemic disease perinatal mental health perinatal period peripartum depression poor sleep prenatal preventive intervention psychosocial racial and ethnic racial discrimination racial minority recruit reward circuitry satisfaction sleep health sleep quality

Address Administrative Supplement Adverse effects Affect Animal Model Animals Architecture Attention Birth Brain COVID-19 COVID-19 pandemic Child Child Health Clinic Clinical Cohort Studies DSM-V Data Data Collection Development Diagnosis Dimensions Discipline of obstetrics Discrimination Drowsiness Economically Deprived Population Electroencephalography Environmental Health Etiology Exposure to Functional Magnetic Resonance Imaging Funding Goals Health Home Hospitals Human Individual Infant Infant Health Infrastructure Interview Investigation Joints Latinx Link Literature Low income Maternal Health Measures Mental Depression Mental Health Monitor Mothers Neighborhoods Nervous System Physiology Neurophysiology - biologic function New York City Outcome Outcome Measure Parents Patient Self-Report Perinatal Pittsburgh Sleep Quality Index Polysomnography Population Postpartum Depression Postpartum Period Pregnancy Pregnant Women Presbyterian Church Prevention program Questionnaires Race Reporting Risk Risk Factors Role Sampling Sleep Sleep Stages Sleep disturbances Stress Structural Racism Structure Surveys Symptoms Testing Underrepresented Populations Woman actigraphy behavioral health brain behavior center for epidemiological studies depression scale clinically significant cohort depressive symptoms disadvantaged background ethnic disparity ethnic minority population experience financial incentive high risk human model individualized prevention interest intervention program maternal caregiving maternal outcome mental function negative affect neural correlate offspring pandemic disease perinatal mental health perinatal period peripartum depression poor sleep prenatal preventive intervention psychosocial racial and ethnic racial discrimination racial minority recruit reward circuitry satisfaction sleep health sleep quality

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项目摘要

This proposal leverages the infrastructure of longitudinal birth cohort study (the Fair Start Cohort within the Columbia Center for Children's Environmental Health) and supplements our investigation of the effects of prenatal bisphenol (BP) exposure on infant nervous system functioning and attention and maternal caregiving (R01ES030950) within the cohort. Prior animal studies show adverse effects of BP exposure on offspring brain development and mother-infant interaction; the R01 seeks to extend these findings to humans. This Administrative Supplement investigates the effects of exposure to experiences of discrimination and COVID- 19-related stress on peripartum depression (PeriPD) and sleep health in these same women. PeriPD and sleep disturbances are common in the perinatal period and negatively affect mother-infant interaction and child health outcomes. Nonetheless etiology of PeriPD and poor sleep health are unclear. Experiences of discrimination and COVID-19-related stress, which burden disproportionately people from racial/ethnic minority and economically disadvantaged backgrounds, have been shown to increase the risk for poor mental and sleep health. Nonetheless, their independent and synergistic role in the perinatal period has not been thoroughly investigated. Understanding upstream risk factors for maternal perinatal mental health and sleep health may provide actionable information to develop prevention and intervention strategies. The funded R01 recruits pregnant women from low income, ethnic/racial minority backgrounds from obstetric clinics associated with Columbia Presbyterian Hospital. In this underrepresented population, the risk for PeriPD and poor sleep health is high. This proposal will fund the assessment of PeriPD (self-report of symptoms, prenatal psychiatric interview), neural correlates of PeriPD (fMRI), and subjective and objective measures of sleep health (self- report of sleep quality, 1-week actigraphy, and 2 days sleep EEG monitoring). We will then investigate associations between experiences of discrimination and COVID-19-related stress and the measured outcomes in a sample of Latinx women from low income backgrounds who are at high risk of exposure to discrimination and COVID-19-related stress. We hypothesize that increased exposure to discrimination and COVID-19- related stress will be associated with increased depression and poorer sleep health in the postpartum period. Our plan is consistent with goals of the Notice of Special interest NOT-OD-21-071 targeting “psychosocial and behavioral health risk factors related to the COVID-19 pandemic that affect maternal mental health and functioning outcome and the impact of structural racism and discrimination (SRD) on maternal health outcomes in the context of COVID-19”. This proposal fills a critical gap in understanding the impact of discrimination and COVID-19-related stress on PeriPD and sleep in mothers from low income, ethnic/racial minority backgrounds at high risk of experiencing both discrimination and COVID-19-related stress.

该提案利用纵向出生队列研究的基础设施（公平的开始队列哥伦比亚儿童环境健康中心）并补充了我们对影响的投资婴儿神经系统功能和关注和孕产妇照顾的产前双酚（BP）暴露（R01ES030950）在队列中。先前的动物研究表明，BP暴露对后代大脑的不利影响发展和母亲互动； R01试图将这些发现扩展到人类。这行政补充调查了暴露于歧视经验和共同经历的影响。这些同一妇女的围围抑郁症（peripd）和睡眠健康的19个相关压力。 peripd和睡眠障碍在围产期很常见，对母亲的互动和儿童产生负面影响健康结果。尽管如此，PERIPD和睡眠不良的病因尚不清楚。经验歧视和共同199的压力，从种族/族裔少数民族中燃烧不成比例的人并且在经济上处于不利地位的背景已被证明增加了精神差的风险和睡眠健康。尽管如此，它们在围产期的独立和协同作用并非彻底调查。了解孕产妇围产期心理健康和睡眠的上游风险因素健康可以为预防和干预策略提供可行的信息。资助的R01 来自低收入的孕妇，来自产科诊所的少数民族背景与哥伦比亚长老会医院一起。在这个人口不足的人群中，佩里普和睡眠不佳的风险健康很高。该建议将资助PERIPD的评估（症状的自我报告，产前精神病学访谈），peripd（fMRI）的神经相关性以及睡眠健康的主观和客观度量（自我睡眠质量的报告，1周的摄影和2天的睡眠脑电图监测）。然后我们将调查歧视经历与19与19与19与19的压力之间的关联与测量结果之间的关联在来自低收入背景的拉丁女性样本中，她们有歧视的高风险和共同19与19的应力。我们假设增加了对歧视和共同19--的暴露。相关的压力将与产后抑郁症增加和睡眠健康较差有关。我们的计划与特殊兴趣通知的目标一致，而不是针对“心理社会和行为健康危险因素与共同-19大流行有关，影响物质心理健康和功能效果以及结构性种族主义和歧视（SRD）对孕产妇健康结果的影响在Covid-19”的背景下。该提案填补了理解歧视和的影响的关键差距来自低收入，种族/种族少数族裔背景的母亲的peripd和睡眠的共同压力遇到歧视和共同199的压力的高风险。