Research Training Program in Adolescent HIV in Haiti

海地青少年艾滋病毒研究培训项目

• 批准号: 10385734
• 负责人: JEAN WILLIAM PAPE
• 金额: $ 30.14万
• 依托单位: GHESKIO CENTER
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-22 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10385734
• 关键词: AIDS prevention; Address; Adolescent; Adult; Area; Black American; Caring; Clinic; Communities; Community Health Aides; Data; Development; Disease; Doctor of Philosophy; Educational Status; Epidemic; Female; Foundations; Future; Grooming; HIV; HIV-infected adolescents; HIV/TB; Haiti; Haitian; Health; Hypertension; Improve Access; Incidence; Infection; Medicine; Outcome; Poverty; Psychologist; Public Health; Public Health Education; Research; Research Support; Research Training; Services; Stigmatization; Training; Training Programs; Training Support; Treatment outcome; Tuberculosis; UNICEF; United States National Institutes of Health; Validation; Youth; adolescent health; adolescent health outcomes; aged; antiretroviral therapy; base; co-infection; cohort; community based research; cost effectiveness; early onset; improved; next generation; programs; social

This proposal builds on the foundation established in Haiti during three decades of NIH research and training support to Groupe Haitien d’Etude du Sarcome et des Infections Opportunistes (GHESKIO) and Weill Cornell Medicine (WCM) to address the burgeoning adolescent HIV epidemic in Haiti. The focus of this training program is to improve HIV-related health outcomes of adolescents (10 to 19 years) and youth (20 to 24 years) in Haiti. A major emphasis is research-training to extend adolescent HIV services from the clinic to the community. Evidence demonstrates that providing services in the community improves access, social acceptability, cost-effectiveness, and ultimately large-scale impact. This program extends graduate level training in Haiti by establishing Haiti’s first PhD program in Public Health. We build upon an MPH program established in Haiti with prior Fogarty support. A cadre of 8 Haitian long-term trainees will receive research training – 4 will receive an MPH and 4 will receive a PhD – the first cohort with doctoral level public health training in Haiti. The research training will focus on adolescent health in the areas of 1) HIV prevention, 2) HIV treatment, 3) HIV and TB co-infection, and 4) HIV and NCDs. Trainees will be groomed to be the future leaders of adolescent health research at GHESKIO and the Haitian Ministry of Health. The program will also include medium-term training (6-12 months) of research staff including psychologists (4), data managers (4), and community health workers (4) to establish community-based research teams. In Haiti, 50% of all new HIV infections are in adolescents and youth, and 80% of these are impoverished and stigmatized females. UNICEF has declared adolescents the ‘center of the HIV epidemic’. HIV-infected adolescents and youth have poor antiretroviral treatment outcomes with only 50% remaining in care after 1 year, compared to 90% retention among adults. The period between 10 and 24 years is the peak incidence of TB infection and disease. Furthermore, only 40% of HIV-infected adolescents with culture-positive TB successfully complete therapy. Finally the rate of early onset hypertension in adolescents and youth in Haiti is 12% - 3-fold greater than in similarly aged Black Americans. The development and validation of community-based approaches to identify, engage, and retain adolescents and youth in care will lead to sustainable improvements in health outcomes in Haiti. This program responds to the priorities of the Haitian Ministry of Health and will train the next generation of Haitian leaders in the conduct of community-based adolescent HIV research.

该提议建立在NIH三十年来在海地建立的基金会建立 对海地的研究和培训支持 机会主义者（Gheskio）和Weill Cornell Medicine（WCM）来解决Brageoning 海地青春期的艾滋病毒流行。该培训计划的重点是改善与HIV相关的 海地的青少年（10至19岁）和青年（20至24岁）的健康成果。专业 重点是研究培训将青少年艾滋病毒服务从诊所扩展到 社区。证据表明，在社区中提供服务可以改善访问权限， 社会可接受性，成本效益和最终大规模影响。 该计划通过建立海地的第一位博士来扩展海地的研究生培训 公共卫生计划。我们基于在海地与先前的Fogarty建立的MPH计划 支持。由8位海地长期学员组成的干部将接受研究培训 - 4名将获得研究培训 MPH和4将获得博士学位 - 第一个接受博士学位公共卫生培训的队列 海地。研究培训将重点介绍1）预防艾滋病毒的青少年健康，2） HIV治疗，3）HIV和TB共感染，以及4）HIV和NCD。学员将被修饰 成为格斯基奥青少年健康研究的未来领导者和海地部 健康。该计划还将包括中期培训（6-12个月）的研究人员 包括心理学家（4），数据经理（4）和社区卫生工作者（4）建立 基于社区的研究团队。 在海地，所有新的艾滋病毒感染中有50％在青少年和青年中，其中80％ 被贫穷和受污名的女性。联合国儿童基金会宣布青少年为“ 艾滋病毒流行”。艾滋病毒感染的青少年和青少年的抗逆转录病毒治疗差 1年后仅剩下50％的护理结果，而保留了90％ 成年人。 10到24年之间的周期是结核病感染的峰值发生率和 疾病。此外，只有40％的HIV感染的青少年具有培养阳性结核病 成功完成治疗。最后，青少年的早期高血压率 海地的青年比同样年迈的黑人美国人高12％ - 倍。 基于社区的方法的发展和验证，以识别，参与和 保留青少年和青年护理将导致健康成果的可持续改善 在海地。该计划回应了海地卫生部的优先事项，并将培训 海地领导人在基于社区的青少年艾滋病毒研究中进行。