The Role of Dietary Nutrients in Chronic Kidney Disease Progression and Apolipoprotein L1 Nephropathy

膳食营养素在慢性肾脏病进展和载脂蛋白 L1 肾病中的作用

基本信息

批准号：
10380175
负责人：
Titilayo Omolara Ilori
金额：
$ 18.52万
依托单位：
BOSTON MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-15 至 2025-03-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10380175
关键词：
Address Africa Africa South of the Sahara African African American population American Anti-Inflammatory Agents Apolipoproteins Biological Markers Biometry Black Populations Boston Career Choice Cessation of life Chronic Kidney Failure Collection Cross-Sectional Studies Data Analyses Development Diabetes Mellitus Dialysis procedure Diet Dietary Factors Dietary Fiber Dietary Potassium Dietary Practices Dietary Sodium Dietary intake Disease Disease Progression Elements End stage renal failure Environmental Exposure Environmental Risk Factor Europe Excretory function Funding Gene Expression Genes Genetic Genetic Risk Genomics Genotype Health High Prevalence Human Incidence Individual Inflammasome Inflammation Inflammatory Inherited Injury to Kidney Institutes Intake Intervention Studies K-Series Research Career Programs Kidney Kidney Diseases Kidney Transplantation Life Life Style Link Maintenance Malignant - descriptor Measures Minority Groups Modification National Institute of Diabetes and Digestive and Kidney Diseases Nutrient Outcome Oxalates Parents Participant Patients Phenotype Population Potassium Potassium Oxalate Prospective Studies Prospective cohort study Public Health Renal function Research Research Project Grants Resources Risk Risk Factors Role Sodium Testing Toxic effect Training Transplantation Universities Urine Variant biobank blood pressure elevation career cost design dietary disease phenotype disorder risk early onset fruits and vegetables gene environment interaction gene interaction genetic epidemiology genetic risk factor global health health disparity high risk medical schools mitochondrial dysfunction modifiable risk nephrotoxicity new therapeutic target novel nutrition nutritional epidemiology patient oriented research professor prospective public health research risk variant skills urinary

项目摘要

PROJECT SUMMARY/ABSTRACT Chronic kidney disease (CKD) individuals Among malignant Apolipoprotein L1 (APOL1). Approximately 13% of African Americans and 25% of West Africans carry high risk renal genotypes, comprising of any combination of the two APOL1 risk variants, G1 and G2. This re-submission for a National Institute of Diabetes and Digestive Kidney Diseases Patient-Oriented Research Career Development Award (K23) seeks to support Dr. Titilayo Ilori, an Assistant Professor at the Boston University School of Medicine, who wants to build a career focused on mechanistic and interventional studies on the effect of dietary factors and lifestyle on CKD incidence and progression in both low- and adequately-resourced settings, especially in the context of genetic and genomic risk variants. Dr. Ilori's prior research has focused on health disparities in CKD and secondary data analysis of nutrition-related exposures and outcomes in kidney disease. Dr. Ilori intends to extend the scope of her research towards designing prospective studies to study the role of dietary sodium and potassium in CKD progression and APOL1 Nephropathy in Africans. Accordingly, her K23 training is focused on acquiring skills in global health research, nutritional and genetic epidemiology in CKD, statistical genetics and advanced biostatistics skills in longitudinal data analysis, and biomarkers of CKD. We propose a research project that leverages the Human Hereditary and Health in Africa Kidney Disease Research Network and addresses the following research aims: 1) a cross-sectional and prospective examination of the associations of dietary sodium, potassium, and oxalate intake – assessed through 24h urine collections in Africans; 2) a cross-sectional and prospective study to determine the associations of dietary patterns with CKD and CKD progression; 3) diet:gene interaction studies to examine whether dietary factors (sodium, potassium, oxalate, or dietary patterns) modify the effect of association of APOL1 renal genotypes on CKD progression. This is an important project because it may identify if dietary factors are modifiable risk factors for CKD progressions in Africans in SSA, where the cost of dialysis and renal transplantation is prohibitive. Additionally, evidence that diet alters the risk of nephropathy in those with high-risk APOL1 renal risk alleles could be important in investigating new therapeutic targets for APOL1 Nephropathy. is effectively a “death sentence” in Sub-Saharan Africa (SSA) where <2% of with end stage renal disease (ESRD) have access to maintenance dialysis or transplantation. Africans with CKD, there is a faster decline in kidney function and earlier onset of ESRD. This CKD phenotype is largely attributable to variants in the gene encoding

项目摘要/摘要慢性肾脏病（CKD）个人之中恶性载脂蛋白L1（apol1）。大约13％的非裔美国人和25％的西非人Cary高风险肾脏基因型，包括两个APOL1风险变体G1和G2的任何组合。这项重新提交了国家糖尿病和消化肾脏疾病的研究研究职业发展奖（K23）旨在支持Titilayo Ilori博士，波士顿大学医学院，他想建立专注于机械和国际的职业研究饮食因素和生活方式对低 - 和低 - 和发展的影响的研究足够的资源设置，尤其是在遗传和基因组风险变体的结合中研究的重点是CKD中的健康差异和与营养有关的暴露的次要数据分析肾脏疾病的结果。前瞻性研究研究饮食钠和钾在CKD进展中的作用和APOL1 因此，非洲人的肾病。 CKD中的营养和遗传流行病学，统计遗传学和纵向的先进生物统计学技能数据分析和CKD的生物标志物。我们提出了一个研究项目，该项目利用非洲肾脏疾病的人类遗传和健康研究网络并解决以下研究的目的：1）横断面和前置检查饮食钠，钾和草酸盐摄入量的关联 - 通过24h尿液评估非洲人的收集； 2）横断面和前瞻性研究 CKD和CKD进展的模式； 3）饮食：基因相互作用研究（钠，钾，草酸盐或饮食模式）修改Apol1肾脏基因型关联对 CKD进展。这是一个重要的项目透析和肾脏移植成本的SSA非洲人进行CKD进行的因素另外，证据表明饮食在具有高风险apol1 renal1 renal1 renal1 renal1的肾病风险风险等位基因在研究APOL1肾病的新疗法靶标可能很重要。是撒哈拉以南非洲（SSA）的有效“死亡中心”，其中<2％随着末期肾脏疾病（ESRD），可以使用维持透析或透明度。具有CKD的非洲人，肾功能的下降速度更快，ESRD发作 CKD表型更大，可归因于编码基因中的变体