Phenotyping obesity using behavioral, psychological, physiological, familial, and genetic data

使用行为、心理、生理、家族和遗传数据对肥胖进行表型分析

• 批准号: 10379362
• 负责人: Alison E Field
• 金额: $ 62.52万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10379362
• 关键词: Adolescence; Adolescent; Adolescent and Young Adult; Adult; Age; Appetitive Behavior; Behavioral; Binge Eating; Body Weight Changes; Body fat; Body mass index; Child; Childhood; Classification; Clinical Trials; Data; Desire for food; Development; Diabetes Mellitus; Disease; Eating; Eating Behavior; Eating Disorders; Environmental Risk Factor; Epidemiology; Family; Family history of; Fatty acid glycerol esters; Genes; Genetic; Growth; Health; Heterogeneity; High Density Lipoproteins; Hunger; Hypertension; Measures; Morbid Obesity; National Institute of Child Health and Human Development; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Overweight; Pattern; Phenotype; Physiological; Predictive Factor; Prevalence; Prevention; Prospective Studies; Race; Research; Risk Factors; Subgroup; United States; Weight; Weight Gain; Youth; bariatric surgery; base; biological sex; early onset; emotional eating; genetic epidemiology; genomic locus; girls; high risk; loss of control over eating; obesity in children; obesity prevention; person centered; polygenic risk score; psychologic; racial disparity; sex; waist circumference; young adult

ABSTRACT Obesity remains highly prevalent among adolescents and young adults in the United States and relatively few youth with overweight or obesity are able to lose weight and maintain the loss, thus making prevention of paramount importance. Although a range of genetic loci and behavioral and environmental factors predictive of weight change and obesity have been identified in prospective studies, their associations with weight gain and obesity have been modest in magnitude. Moreover, the numerous clinical trials aimed at prevention of obesity in children and adolescents have yielded modest effects. One possible reason for the lack of observing large effects in observational studies or clinical trials is that all types of overweight and obesity are often grouped together. One potential consequence of overlooking the heterogeneity in obesity is missing or underestimating risk factors for specific subtypes of obesity. An alternative strategy is to identify subtypes and examine subtype- specific associations. More careful phenotyping of obesity could potentially be used to advance the field of obesity epidemiology and treatment. Research is needed to identify the range of obesity phenotypes and whether there are differences in obesity subtypes by biological sex and race. We propose using appetitive behaviors, psychological, behavioral, anthropometric, physiological, genetic, and familial data, in a person-centered approach to empirically identify subtypes of obesity and to investigate whether the subtypes vary by biological sex or race. We will use data collected from the 2379 girls in National Growth and Health Study, 1421 children (48% with obesity and 17% with overweight) studied in the Section on Growth and Obesity at the Eunice Shriver Kennedy National Institute of Child Health and Human Development (NICHD), and the 16,850 youth in the Growing Up Today Study (14.9% with obesity and 29% with overweight). We will use latent class analysis to identify subgroups of obesity and then examine whether the empirically-derived phenotypes are predictive of weight change in adolescence and young adulthood, the development of hypertension before age 35, or have a differential pattern of association with the obesity loci. In addition, we will examine whether the phenotypes vary by biological sex or race and whether the associations of phenotypes with weight change in adolescence and young adulthood and the development of hypertension before age 35, vary by biological sex or race. The results of our proposed study could have a major impact on the field. The first step towards decreasing disparities by race and sex is to examine if there are differences in presentation and course of a disorder. Our study will provide that much needed information, which could result in tailored and more effective prevention and treatments.

抽象的 在美国的青少年和年轻人中，肥胖仍然很普遍 超重或肥胖的年轻人相对较少能够减轻体重和维持损失，因此 预防最重要的重要性。虽然一系列遗传基因座和行为和 在预期中已经确定了体重变化和肥胖的环境因素 研究，它们与体重增加和肥胖症的关联在大小上是适度的。而且， 旨在预防儿童和青少年肥胖的众多临床试验产生了 适度的效果。在观察研究或 临床试验是，所有类型的超重和肥胖通常都被分组在一起。一个潜力 忽视肥胖中异质性的后果是缺失或低估了风险因素 肥胖的特定亚型。另一种策略是识别亚型并检查亚型 具体关联。肥胖的更仔细的表型可能可能用于推进 肥胖病流行病学和治疗领域。需要研究以识别肥胖的范围 表型以及肥胖子类型是否有生物性别和种族有差异。我们 建议使用食欲，心理，行为，人体测量，生理，遗传， 和家族数据，以以人为中心的方法来识别肥胖的亚型和 调查子类型是否因生物性别还是种族而有所不同。我们将使用从 2379名国家成长和健康研究中的女孩，1421名儿童（肥胖症为48％，有17％的儿童 超重）在Eunice Shriver Kennedy National的有关增长和肥胖的部分中研究 儿童健康与人类发展研究所（NICHD）和成长中的16,850名青年 今天的研究（肥胖症有14.9％，超重29％）。我们将使用潜在类分析来 识别肥胖的亚组，然后检查经验衍生的表型是否是 预测青春期和年轻成年的体重变化，高血压的发展 在35岁之前，或与肥胖基因座具有差异模式。此外，我们将 检查表型是否因生物学性别还是种族而有所不同，以及 体重变化的表型和年轻的成年和发展 35岁之前的高血压因生物学或种族而异。我们提出的研究的结果可能 对该领域有重大影响。迈向种族和性别差异的第一步是 检查疾病的表现和过程是否存在差异。我们的研究将提供 急需的信息，这可能导致量身定制，更有效的预防和治疗方法。