Phenotyping obesity using behavioral, psychological, physiological, familial, and genetic data

使用行为、心理、生理、家族和遗传数据对肥胖进行表型分析

• 批准号: 10379362
• 负责人: Alison E Field
• 金额: $ 62.52万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10379362
• 关键词: Adolescence; Adolescent; Adolescent and Young Adult; Adult; Age; Appetitive Behavior; Behavioral; Binge Eating; Body Weight Changes; Body fat; Body mass index; Child; Childhood; Classification; Clinical Trials; Data; Desire for food; Development; Diabetes Mellitus; Disease; Eating; Eating Behavior; Eating Disorders; Environmental Risk Factor; Epidemiology; Family; Family history of; Fatty acid glycerol esters; Genes; Genetic; Growth; Health; Heterogeneity; High Density Lipoproteins; Hunger; Hypertension; Measures; Morbid Obesity; National Institute of Child Health and Human Development; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Observational Study; Overweight; Pattern; Phenotype; Physiological; Predictive Factor; Prevalence; Prevention; Prospective Studies; Race; Research; Risk Factors; Subgroup; United States; Weight; Weight Gain; Youth; bariatric surgery; base; biological sex; early onset; emotional eating; genetic epidemiology; genomic locus; girls; high risk; loss of control over eating; obesity in children; obesity prevention; person centered; polygenic risk score; psychologic; racial disparity; sex; waist circumference; young adult

ABSTRACT Obesity remains highly prevalent among adolescents and young adults in the United States and relatively few youth with overweight or obesity are able to lose weight and maintain the loss, thus making prevention of paramount importance. Although a range of genetic loci and behavioral and environmental factors predictive of weight change and obesity have been identified in prospective studies, their associations with weight gain and obesity have been modest in magnitude. Moreover, the numerous clinical trials aimed at prevention of obesity in children and adolescents have yielded modest effects. One possible reason for the lack of observing large effects in observational studies or clinical trials is that all types of overweight and obesity are often grouped together. One potential consequence of overlooking the heterogeneity in obesity is missing or underestimating risk factors for specific subtypes of obesity. An alternative strategy is to identify subtypes and examine subtype- specific associations. More careful phenotyping of obesity could potentially be used to advance the field of obesity epidemiology and treatment. Research is needed to identify the range of obesity phenotypes and whether there are differences in obesity subtypes by biological sex and race. We propose using appetitive behaviors, psychological, behavioral, anthropometric, physiological, genetic, and familial data, in a person-centered approach to empirically identify subtypes of obesity and to investigate whether the subtypes vary by biological sex or race. We will use data collected from the 2379 girls in National Growth and Health Study, 1421 children (48% with obesity and 17% with overweight) studied in the Section on Growth and Obesity at the Eunice Shriver Kennedy National Institute of Child Health and Human Development (NICHD), and the 16,850 youth in the Growing Up Today Study (14.9% with obesity and 29% with overweight). We will use latent class analysis to identify subgroups of obesity and then examine whether the empirically-derived phenotypes are predictive of weight change in adolescence and young adulthood, the development of hypertension before age 35, or have a differential pattern of association with the obesity loci. In addition, we will examine whether the phenotypes vary by biological sex or race and whether the associations of phenotypes with weight change in adolescence and young adulthood and the development of hypertension before age 35, vary by biological sex or race. The results of our proposed study could have a major impact on the field. The first step towards decreasing disparities by race and sex is to examine if there are differences in presentation and course of a disorder. Our study will provide that much needed information, which could result in tailored and more effective prevention and treatments.

抽象的 肥胖在美国青少年和年轻人中仍然非常普遍 相对较少的超重或肥胖青少年能够减肥并维持体重，因此 坚持预防为主。尽管一系列遗传位点和行为和 前瞻性地确定了预测体重变化和肥胖的环境因素 研究表明，它们与体重增加和肥胖的关联程度不大。而且， 旨在预防儿童和青少年肥胖的大量临床试验已取得成果 影响不大。在观察性研究中缺乏观察到大效应的可能原因之一或 临床试验表明，所有类型的超重和肥胖常常被归为一类。一种潜力 忽视肥胖异质性的后果是遗漏或低估了肥胖的危险因素 肥胖的特定亚型。另一种策略是识别亚型并检查亚型 具体协会。更仔细的肥胖表型分析可能有助于推进 肥胖流行病学和治疗领域。需要研究来确定肥胖的范围 表型以及肥胖亚型是否因生物性别和种族而存在差异。我们 建议使用食欲行为、心理、行为、人体测量、生理、遗传、 和家族数据，采用以人为本的方法，凭经验识别肥胖亚型并 研究亚型是否因生物性别或种族而异。我们将使用从 国家生长与健康研究中有 2379 名女孩，1421 名儿童（48% 患有肥胖症，17% 患有肥胖症） 尤尼斯施赖弗肯尼迪国立大学生长与肥胖部门研究的超重） 儿童健康与人类发展研究所 (NICHD)，以及成长中的 16,850 名青少年 今日研究（14.9% 肥胖，29% 超重）。我们将使用潜在类别分析来 确定肥胖的亚组，然后检查凭经验得出的表型是否符合 预测青春期和成年早期的体重变化、高血压的发展 35 岁之前，或与肥胖位点有不同的关联模式。此外，我们将 检查表型是否因生物性别或种族而异，以及 青春期和青年期体重变化的表型以及发育 35 岁之前的高血压，因生物性别或种族而异。我们提出的研究结果可以 领域产生重大影响。减少种族和性别差异的第一步是 检查疾病的表现和病程是否存在差异。我们的研究将提供这一点 急需信息，这可能会导致有针对性的、更有效的预防和治疗。