Research Training - Genetics of Substance Abuse

研究培训 - 药物滥用的遗传学

• 批准号: 10381506
• 负责人: JERRY A STITZEL
• 金额: $ 34.7万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10381506
• 关键词: Genetic; Research Training; Substance abuse problem

PROJECT SUMMARY This proposal seeks continued support, via an institutional training grant, for a training program for pre and postdoctoral fellows who will pursue research careers that focus on genetic influences on substance abuse. The faculty, from the Institute for Behavioral Genetics (IBG) and collaborating units, is distinguished and active in research, and IBG scientists have actively pursued studies of genetic influences on substance abuse for over 50 years. Major substance abuse-related research projects are in progress in both human and animal behavior genetics. The application of biometrical, statistical, and quantitative genetic techniques, together with bioinformatics, genome-wide analyses and next generation sequencing, and epigenetics, is providing real advances in knowledge. Neuro-chemical, -pharmacological, -physiological, and molecular genetic studies, are providing an understanding of gene function related to behavior. Since our last application, we have added a major commitment to functional and structural brain imaging as a research tool and have expanded our faculty and training program accordingly. Our research and training include the use of large scale collaborative studies that are amassing DNA repositories and rich phenotypic data sets available for studies of substance abuse. These include the Adolescent Brain Cognitive Development (ABCD) study, for which our training faculty are PIs of the twin study component, the NIDA Genetics Consortium, the Psychiatric Genetics Consortium, the UK Biobank, and GSCAN, a genome wide study of over 1 million cases. IBG facilities are available for gene function and expression studies, and behavioral, biochemical, and neurophysiological studies, and we are actively pursuing animal model studies of the functional implications of SNPs robustly associated with drug phenotypes in the human population. To reflect the expanded need for training, particularly for genetics expertise applied in the context of ABCD, brain imaging, translational research, and `big data' studies, funds are requested to support 6 pre-doctoral and 3 postdoctoral trainees. Trainees will typically be supported for up to 3 years. Pre-doctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, neuroscience, bioinformatics and genomics, mandatory training in the responsible conduct of research, and courses on behavioral, brain imaging, and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities in preparation for research careers in substance abuse include: supervision of students and/or technicians, hosting of seminar speakers and conference organization, guest lecturing, a weekly journal club, grant writing, and the development of individual professional plans.

项目摘要 该提案通过机构培训补助金寻求持续支持，以供Pre和 博士后研究员将从事研究遗传影响对药物滥用的研究。 行为遗传学研究所（IBG）和合作单位的教师是显着的和活跃的 在研究中，以及IBG科学家积极地研究了对遗传滥用药物滥用的研究 超过50年。人类和动物的主要滥用研究项目正在进行中 行为遗传学。生物识别，统计和定量遗传技术的应用以及 生物信息学，全基因组分析和下一代测序以及表观遗传学正在提供真实 知识的进步。神经化学， - 药理学， - 生理学和分子遗传研究是 提供对与行为有关的基因功能的理解。自上次申请以来，我们添加了 将功能性和结构性脑成像作为研究工具的主要承诺，并扩大了我们的教师 和培训计划。我们的研究和培训包括使用大规模协作研究 积累了DNA存储库和丰富的表型数据集可用于研究药物滥用。 其中包括青春期的大脑认知发展（ABCD）研究，我们的培训教师是 双胞胎研究成分的PI，NIDA遗传学财团，精神遗传学财团，英国 生物库和GSCAN，一项基因组广泛研究，对超过100万例病例。 IBG设施可用于基因 功能和表达研究以及行为，生化和神经生理学研究，我们是 积极地追求与药物牢固相关的SNP功能含义的动物模型研究 人口中的表型。为了反映培训的不断扩展的需求，特别是遗传学 在ABCD，大脑成像，翻译研究和“大数据”研究的背景下应用的专业知识，资金 要求支持6名博士后和3名博士后学员。通常将支持学员 到3年。博士前学员获得合作学术单位和认证的博士学位 在行为遗传学中。培训计划中的学术要求包括行为遗传学培训， 定量和生物识别遗传学，理论和基于计算机的统计数据，分子遗传学， 神经科学，生物信息学和基因组学，负责任进行研究的强制性培训以及 有关行为，脑成像和临床表型的课程。其他要求根据 学位授予学术单位。研究是培训的组成部分。博士后学员也从事 正式的计划，强调个人研究以及分子和定量的能力 行为遗传学。为滥用药物的研究职业准备的其他活动包括：监督 学生和/或技术人员的主持人主持演讲者和会议组织，客人讲课， 每周期刊俱乐部，赠款写作以及个人专业计划的制定。