Improving Kidney Health Assessment in Young Patients with Spina Bifida

改善年轻脊柱裂患者的肾脏健康评估

• 批准号: 10378062
• 负责人: David Chu
• 金额: $ 19.01万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10378062
• 关键词: Address; Adolescent and Young Adult; Adult; Advisory Committees; Affect; Assessment tool; Attitude; Award; Belief; Bladder; Cardiovascular Diseases; Caregivers; Caring; Catheterization; Centers for Disease Control and Prevention (U.S.); Cessation of life; Childhood; Chronic Kidney Failure; Clinic; Collaborations; Congenital Abnormality; Consensus; Data; Detection; Development; Development Plans; Disease Progression; Disease Surveillance; Doctor of Philosophy; Educational Intervention; Educational workshop; End stage renal failure; Ensure; Environment; Equation; Evaluation; Extramural Activities; Feasibility Studies; Fostering; Foundations; Funding; Future; Glomerular Filtration Rate; Goals; Gold; Guidelines; Health; Healthcare; Impairment; Infant; Institutes; Intervention; Interview; Iohexol; K-Series Research Career Programs; Kidney; Knowledge; Lead; Measures; Medicine; Mentors; Mentorship; Methodology; Modeling; Neurogenic Bladder; Operative Surgical Procedures; Patients; Pediatric Hospitals; Plasma; Population; Positioning Attribute; Predisposition; Process; Prospective cohort study; Protocols documentation; Provider; Public Health; Qualitative Research; Reconstructive Surgical Procedures; Registries; Renal function; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Support; Resources; Review Literature; Science; Scientist; Self Care; Severities; Spinal Dysraphism; Structure; Surgeon; Surveillance Methods; Testing; Theoretical model; Time; Training; Translating; Uncertainty; United States; Universities; Urology; Validation; career; career development; clinical epidemiology; clinical practice; clinical translation; cohort; cost; diagnostic strategy; diagnostic tool; experience; future implementation; health assessment; health belief; health literacy; high risk population; implementation facilitators; implementation intervention; implementation research; implementation science; implementation study; improved; improved outcome; informant; insight; instrument; kidney preservation; multidisciplinary; novel; patient engagement; patient oriented; patient oriented research; predictive modeling; preference; pressure; prevent; programs; provider factors; reduced muscle mass; skills; standard measure; surveillance strategy; systematic review; tool; urologic; validation studies

PROJECT SUMMARY This Career Development Award will help David I. Chu, MD, MSCE, become an independent surgeon-scientist who will develop the evidence to improve kidney, bladder, and overall health in young patients with spina bifida. Dr. Chu will use this award to build on his existing foundation in clinical epidemiology to achieve five career development goals: 1) Develop expertise in patient-oriented research (POR); 2) Acquire experience in qualitative research; 3) Gain knowledge in creating and implementing consensus strategies; 4) Strengthen research portfolio and grantsmanship skills; and 5) Build inter-disciplinary, multi-institutional research collaborations. These skills will allow him to translate research into clinical practice to improve outcomes in patients with spina bifida. Dr. Chu will achieve these career objectives through a career development plan that consists of intensive experiential training, structured didactics and workshops, and a comprehensive mentoring program. His Primary Mentor is Dr. Tamara Isakova, an expert in POR in chronic kidney disease with an outstanding record of extramural funding and mentorship. His Co-Mentor is Dr. Earl Cheng, a national leader in pediatric urologic reconstructive surgery and spina bifida care. His Advisory Committee includes interdisciplinary experts in kidney function equations (Dr. Susan Furth, MD, PhD), qualitative research (Dr. Elisa Gordon, PhD, MPH), consensus-building and implementation in surgery (Dr. Mehul Raval, MD, MS), and advanced implementation science methodology (Dr. Justin Smith, PhD). Dr. Chu’s career development plan will be supported by the exceptional institutional environment of Lurie Children’s Hospital and Northwestern University, including the 1) Dedicated resources and research infrastructure within Lurie Children’s Hospital’s Division of Urology and Department of Surgery; 2) Robust, high-volume, and multi-disciplinary Lurie Children’s Hospital Spina Bifida Clinic; and 3) Strong research support from Northwestern University’s Clinical and Translation Sciences Institute and the Institute for Public Health and Medicine. The overall objective of this scientific proposal is to improve kidney health assessment tools and approaches in young patients with spina bifida. Various guidelines prioritize preserving kidney health in these patients, but preliminary evidence suggests that current tools and approaches for assessing kidney health are inaccurate, not patient-centered, and not uniformly implemented by providers. The Aims of this proposal are to: 1) Compare current kidney function estimating equations to gold-standard iohexol plasma clearance tests and develop novel, spina-bifida- specific equations; 2) Assess patient knowledge, attitudes, and beliefs towards kidney health and evaluation, guided by the revised Health Belief Model; and 3) Assess provider preferences, barriers, and facilitators towards kidney health surveillance methods and strategies to create consensus implementation practices. The combination of advanced quantitative, qualitative, and implementation research methods and mentored training will ensure Dr. Chu emerges as a highly successful, independent investigator in spina bifida care.

项目摘要 该职业发展奖将帮助MSCE医学博士David I. Chu成为独立的外科医生科学家 谁将开发证据以改善脊柱年轻患者的肾脏，膀胱和整体健康状况 叶。 Chu博士将使用该奖项来建立他在临床流行病学中现有的基础以实现五个 职业发展目标：1）发展面向患者的研究（POR）方面的专业知识； 2）获得 定性研究； 3）在创建和实施共识策略方面获得知识； 4）加强 研究组合和赠款技巧； 5）建立跨学科的多机构研究 协作。这些技能将使他能够将研究转化为临床实践，以改善 脊柱裂的患者。 Chu博士将通过一项职业发展计划实现这些职业目标 包括密集的专家培训，结构化的教学和讲习班以及全面的心理 程序。他的主要导师是塔玛拉·伊萨科娃（Tamara Isakova）博士，他是慢性肾脏病的专家 出色的卫生资金和心态记录。他的院长是厄尔·陈（Earl Cheng）博士 小儿泌尿外科重建手术和脊柱裂。他的咨询委员会包括 肾脏功能方程的跨学科专家（医学博士Susan Fuurth博士），定性研究（博士 Elisa Gordon博士，MPH），手术中的共识和实施（Mehul Raval博士，医学博士，MS）和 高级实施科学方法论（Justin Smith博士博士）。 Chu博士的职业发展计划 Lurie儿童医院和西北地区的杰出机构环境将支持 大学，包括1）Lurie儿童医院内的专用资源和研究基础设施 泌尿外科和外科系； 2）健壮，大量和多学科Lurie儿童 医院脊柱裂诊所； 3）西北大学临床和 翻译科学研究所和公共卫生与医学研究所。总体目标 科学建议是改善脊柱年轻患者的肾脏健康评估工具和方法 叶。各种准则优先考虑这些患者的肾脏健康，但初步证据 建议当前评估肾脏健康的工具和方法不准确，不是以患者为中心， 并且不是由提供者统一实施的。该提议的目的是：1）比较当前的肾脏 对金标准iohexol等离子体清除测试的功能估计方程式，并开发新颖的spina-bifida- 特定方程； 2）评估患者知识，与会者，并相信肾脏健康和评估， 在修订后的健康信念模型的指导下； 3）评估提供商的偏好，障碍和促进者 采取肾脏健康监视方法和建立共识实施实践的策略。这 高级定量，定性和实施研究方法的结合和指导 培训将确保Chu博士成为脊柱裂野田护理中非常成功的独立研究者。